Infrared thermography and dual-layer spectral CT for the detection of femoral vascular compromise: an experimental large animal study.
BACKGROUND: Rapid identification of vascular compromise remains a clinical challenge in the acute trauma setting. Conventional diagnostic tools such as CT angiography (CTA) and Doppler-ultrasound migh...
N-Acetylcysteine protects the developing brain in neonatal sepsis-like inflammation via a redox-neurovascular pathway.
BACKGROUND: Neonatal sepsis can disrupt brain development through oxidative stress, blood-brain barrier (BBB) dysfunction, peripheral leukocyte infiltration, and white matter injury. N-acetylcysteine ...
Fractionated stereotactic radiotherapy (fSRT) for symptomatic WHO grade 1 cavernous sinus meningiomas: long-term local control, clinical response, and toxicity outcomes.
PURPOSE: Cavernous sinus meningiomas represent a significant clinical challenge, given the high prevalence of neurological deficits and limited surgical options. Radiation therapy is often the preferr...
Skin capillary endothelial cells form a network of spatiotemporally conserved Ca(2+) activity.
Ca2+ signaling and its regulation are important for endothelial cell (EC) function and signaling. Yet, the spatiotemporal organization of Ca2+ activity and its regulation across a vascular plexus is p...
RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes.
Autosomal dominant kidney hypomagnesemia with RRAGD variants (ADKH-RRAGD) is a hereditary disorder characterized by kidney tubulopathy and dilated cardiomyopathy (DCM). RagD, encoded by the RRAGD gene...
Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue.
Dengue is an arboviral disease with major global public health impact. Its pathophysiology involves complex interactions between the virus and the host, including the immune response and the vascular ...
Returning to diving and hyperbaric exposure after pulmonary vein isolation for atrial fibrillation.
Pulmonary vein isolation (PVI) is an established rhythm-control therapy for atrial fibrillation (AF), yet the electrophysiological response of post-PVI individuals exposed to hyperbaric environments r...
Hirsutine Ameliorates High-Fat Diet-Induced Cardiomyopathy Through Promoting LRPPRC-Regulated Mitophagy via the PINK1/Parkin Axis in Mice.
Hirsutine, a potent drug-like indole alkaloid extracted from Uncaria rhynchophylla, exhibits several biological activities, including cardioprotective effects. However, the underlying regulatory mecha...
Vagal nerve stimulation (VNS) may reverse autonomic dysfunction in heart failure (HF). This paper describes results from a pivotal trial, while addressing challenges investigators face following prema...
Dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) are progressive cardiac muscle disorders with phenotypic and genetic overlap. Although a male predominance is noted in DCM/ACM, it ...
Early identification of worsening heart failure (HF) may improve outcomes.
Oxidative Stress and Its Impact on Reperfused Myocardium: Pathophysiological Insights and Therapeutic Perspectives.
Myocardial ischemia-reperfusion injury (MIRI) represents a major contributor to morbidity and mortality in patients undergoing reperfusion therapy after acute myocardial infarction. Although timely re...
Albumin-Based Drug Delivery for Glioblastoma Treatment: Mechanistic Rationale, Preclinical Evidence, and Clinical Translation.
Glioblastoma remains the most aggressive primary brain malignancy, with poor survival despite maximal safe resection, radiotherapy, and temozolomide-based chemotherapy. A major obstacle to effective t...
Pre-Deployment Evaluation of a Remote Service for Short-Axis Cardiac MRI Segmentation.
Deploying cardiac segmentation models as remote inference services creates a black-box setting in which robustness under out-of-distribution shift is critical. We evaluated two candidate configuration...
The Immediate Impact of Infarct Size on the Systemic Inflammatory Response: IL-6 as Central Mediator Identified through Biomarker and Proteomic Profiling.
Myocardial infarction (MI) induces an inflammatory response that may be amenable to targeted therapy. This cohort study evaluated the systemic inflammatory burden across different infarct sizes using ...
Old marker, new face: anti-RNP as a sentinel of coronary and peripheral endothelial dysfunction in systemic lupus erythematosus.
OBJECTIVE: To investigate the association between anti-ribonucleoprotein (anti-RNP) antibodies and endothelial dysfunction (ED) in patients with SLE and their ability to predict early ED manifestation...
Harnessing Regulatory T Cells to Modulate Acute Brain Injury: From Mechanisms to Therapy.
Neuroinflammation is a defining feature of acute brain injury such as acute ischemic stroke, traumatic brain injury, intracerebral hemorrhage, and subarachnoid hemorrhage, driven by complex immune int...
Early implementation of transradial mechanical thrombectomy in a primary stroke center: a sequential cohort propensity score-matched study.
BACKGROUND: This study assessed the early implementation of transradial access (TRA) for mechanical thrombectomy (MT) in a primary stroke center (PSC) using a retrospective sequential cohort design wi...
Left Atrial Structural and Functional Changes After Pulmonary Vein Isolation Using Different Energy Sources.
Background: Pulmonary vein isolation (PVI) is an established treatment for atrial fibrillation (AF); however, its impact on long-term left atrial (LA) structural and mechanical remodeling may differ b...