Modeling Neuroimmunological Interactions at the Blood-Brain Barrier Using In Vitro 3D Human Organoids: Inflammation and Ischemia-Reperfusion Injury.
Numerous central nervous system pathological conditions involve blood-brain barrier (BBB) disruption and the egress of immune cells in the brain. Controlling immune cell transmigration into the brain ...
Responsiveness to adenosine diphosphate on carotid arterial and platelet functions in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats.
Extracellular nucleotides, including adenosine diphosphate (ADP), are pivotal in regulating vascular and platelet function. Thus, their abnormal function contributes significantly to the initiation an...
Hepatic artery aneurysm rupture into the biliary tract during long-term left ventricular assist device support successfully treated by transcatheter arterial embolization: a case report.
Bleeding complications remain a major concern in patients supported by long-term left ventricular assist devices (LVADs). Although gastrointestinal bleeding is common, hemobilia due to rupture of a he...
Neurotherapeutic roles of the protective arm of the renin-angiotensin system: from inflammation to cognitive rescue.
The renin-angiotensin system (RAS), traditionally recognized for its role in regulating blood pressure and fluid homeostasis, is increasingly understood to exert important effects across multiple orga...
Parameter estimation in blood flow models from highly undersampled k-space magnetic resonance imaging data.
4D Flow Magnetic Resonance Imaging (MRI) is the state-of-the-art technique for measuring blood flow and provides valuable data for inverse problems in the cardiovascular system. However, acquiring 4D ...
Secoisolariciresinol diglucoside ameliorates muscarinic acetylcholine receptor mediated activation of NLRP3 inflammasome in cardiomyocytes.
BACKGROUND: Secoisolariciresinol diglucoside (SDG), the main lignan found in flaxseed, contributes to cardioprotection. However, its molecular mechanism of action remains unknown. NOD-like receptor pr...
Endovascular treatment of tumor-related dural sinus stenosis, venous outflow obstruction, and secondary intracranial hypertension: a systematic review of the literature.
INTRODUCTION: Tumors involving dural venous sinuses can lead to venous outflow obstruction and secondary intracranial hypertension. While surgical resection can decompress the sinus, such procedures c...
Cardiac Metabolism in Healthy, Senescent and Diseased States.
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. The healthy adult heart depends on flexible energy use, but a diseased or injured heart is associated with a loss of flexibili...
The Role of LRP1 in Glioma Progression and Therapeutic Targeting: A Narrative Review.
Gliomas are the most frequently encountered tumors in the central nervous system, with limited therapeutic effectiveness owing to their highly invasive nature, intratumoral heterogeneity, and presence...
Glymphatic-Related Alterations in Major Depressive Disorder and Treatment-Resistant Depression: Imaging Proxies, Mechanistic Links, and Therapeutic Opportunities.
Major depressive disorder is increasingly conceptualized as a condition involving brain network dysfunction, neuroimmune imbalance, sleep-circadian disruption, hypothalamic-pituitary-adrenal (HPA)-axi...
Retrospective study on hemodynamic and morphological characteristics of posterior communicating artery aneurysms associated with fetal-type posterior cerebral artery and their correlation with rupture risk.
The fetal-type posterior cerebral artery (fPCA) is a prevalent anatomical variant that may influence the hemodynamics and shape of posterior communicating artery aneurysms (PCoAAs). Nonetheless, its i...
Successful minimal-invasive management of misplaced sacroiliac screw perforating the left external iliac vein: an interdisciplinary intervention by angiology and traumatology-a case report.
BACKGROUND: Percutaneous sacroiliac screw fixation is an effective option for unstable pelvic ring fractures. It is minimally invasive, causes little soft tissue damage, and reduces complication risk....
Right chylothorax following right internal jugular vein cannulation.
Iatrogenic chylothorax, a rare but serious complication, can occur after central venous catheter (CVC) placement. It is usually linked to left internal jugular vein (IJV) cannulation due to the anatom...
Three-dimensional physical models of fetal hearts with congenital heart diseases.
The prognostic impact of microvascular invasion in patients with cholangiocarcinoma: A retrospective study.
Cholangiocarcinoma (CCA) is the second most prevalent primary liver cancer. Microvascular invasion (MVI) indicates more aggressive tumor behavior. While surgery is the primary curative treatment, recu...
VMA21 deficiency leads to autophagic dysregulation and altered vesicle trafficking in X-linked myopathy with excessive autophagy.
X-Linked myopathy with excessive autophagy (XMEA) is a rare vacuolar myopathy caused by mutations in Vma21, an assembly chaperone required for vacuolar H⁺-ATPase (V-ATPase) function. However, the mech...
Accessory head of the sartorius arising from the femoral sheath: an anatomical variant with its clinical implications.
PURPOSE: The sartorius muscle is a strap muscle in the front of the thigh that contributes to movements of the hip and knee joints. Variation in the origin and insertion of this muscle is rare but cli...
Endothelial-to-mesenchymal transition (EndMT) has emerged as a pathophysiological process responsible for various chronic vascular diseases, particularly atherosclerosis. However, the molecular pathwa...
Atherosclerosis and arteriosclerosis are major contributors to cardiovascular disease (CVD), yet their shared and distinct molecular underpinnings remain incompletely understood. This study integrates...
Following myocardial infarction (MI), reperfusion strategies ensure that blood flow is promptly restored to salvage the ischaemic myocardium. However, the sudden restoration of blood flow can inflict ...