Inflammasome-Driven Cardiac Fibrosis in Cardiometabolic Disease and Arrhythmias: Mechanisms, Biomarkers, and Therapeutic Targets.

Chronic low-grade inflammation and maladaptive extracellular matrix remodeling co-evolve across atrial fibrillation, heart failure phenotypes, diabetic cardiomyopathy, and aortic valve stenosis. Emerg...

[Novel framework based on multi-stage random sampling and differentiable rendering for automated three-dimensional orientation estimation of skull base foramina].

The foramen ovale and foramen rotundum of the skull base serve as critical anatomical approaches for percutaneous puncture of the trigeminal ganglion. Their three-dimensional orientation is crucial fo...

[MSCNet: Coronary artery segmentation network with multi-scale cascade encoding and dynamic spatial context enhancement].

Coronary artery segmentation is a critical step in the clinical diagnosis of coronary heart disease. To tackle segmentation breaks and false segmentation caused by the thin and complex coronary vessel...

IGF-1 Inhibits the Hemodynamics‑Induced Progression of Intracranial Aneurysms by Modulating the Proliferation and Apoptosis of Vascular Smooth Muscle Cells.

Abnormal shear stress is closely linked to the progression of intracranial aneurysms (IAs) and the apoptosis of middle layer of vascular wall. Insulin-like growth factor-1 (IGF-1) is crucial for vascu...

Integrative Bioinformatics and Experimental Validation Identify LOX as a Glycolysis-Related Biomarker in Myocardial Ischemia-Reperfusion Injury.

Reprogramming of glycolytic metabolism plays a critical role in the pathogenesis of myocardial ischemia-reperfusion injury (MIRI). Although transient glycolysis activation may alleviate energy deficit...

Cellular accumulation of lipofuscin in the heart: implications in health and disease.

Lipofuscin is a subcellular pigmented granule that has long been considered a sign of wear-and-tear and aging. This granule cannot be degraded but may be diluted by cell division. In the heart, lipofu...

Prenatal and Lactational Exposure to Polystyrene Nanoplastics Induces Lipid Accumulation in Vascular Smooth Muscle Cells of Male Offspring via the MAPK/ERK/UHRF1 Signaling Pathway.

Nanoplastics (NPs) have been shown to cross the placental barrier and disrupt systemic metabolism, raising concerns about their potential impact on developmental health. Despite accumulating evidence ...

[Application prospects of the combined isolated heart perfusion and calcium transient myocardial contraction measurement techniques in cardiovascular protective mechanisms research of acupuncture].

Acupuncture has demonstrated unique potential in the treatment of cardiovascular diseases, yet its further scientific advancement and international recognition still require breakthroughs in mechanism...

[Mechanism of electroacupuncture at "Neiguan" (PC6) and "Jianshi" (PC5) in ameliorating blood-brain barrier damage in APP/PS1 mice based on the nucleus tractus solitarius-locus coeruleus neural circuit].

OBJECTIVES: To observe the role of tyrosine hydroxylase (TH)-positive neurons in the nucleus tractus solitarius (NTS) and locus coeruleus (LC) in electroacupuncture (EA)-mediated improvement of blood-...

Preclinical evaluation of cysteine protease-inhibitor aloxistatin (E64d) for heart failure therapy.

Heart failure (HF) affects over 64 million people worldwide causally linked to fibrotic scarring. None of the available cardiac drugs target fibrosis directly, underlining unmet clinical need for nove...

Empagliflozin Protects Against Doxorubicin Cardiotoxicity: Integrative Assessment of Cardiac Kinetics and Electrophysiology Using Machine Learning in a Rat Model.

Background/Objectives: Anthracycline-induced cardiotoxicity remains a major challenge in cancer treatment, and researchers are showing interest in artificial intelligence (AI) to improve the predictio...

Coronary Artery Vasospasm: Cellular and Molecular Insights.

Coronary artery vasospasm (CAV) is a transient, reversible constriction of the epicardial coronary arteries that reduces coronary blood flow and may cause myocardial ischemia. Despite its clinical sig...

Identification of the Mitochondrial Gene NME6 as an Immune Modulator in Heart Failure.

BACKGROUND: Heart failure (HF) is characterized by mitochondrial dysfunction and immune dysregulation. However, the underlying molecular mechanisms remain unclear. Functional enrichment analyses study...

SPI1 Promotes Intracranial Aneurysm Formation by Inhibiting Wnt5a Transcription.

BACKGROUND: SPI1 is a hub gene associated with intracranial aneurysms (IA) and is highly expressed in IA tissues. However, its functional role in IA formation remains unclear. This study aimed to inve...

Impact of superior mesenteric artery (SMA) adherent tissue in the context of pancreatic head resections- an observational study.

BACKGROUND: Resection of the periadventitial neurolymphatic tissue around the superior mesenteric artery (SMA) is considered a crucial component of oncologically complete resection in pancreatic head ...

Morphological and functional evaluation of the left ventricle in severe aortic stenosis with afterload mismatch: a South African single-centre, cross-sectional cardiovascular MRI-based study.

OBJECTIVES: This study aimed to investigate the relationship between left ventricular (LV) remodelling and systolic function in high-gradient severe aortic stenosis (AS) using cardiovascular magnetic ...

Postoperative Physiologic Comfort Management for Patients With Hepatocellular Carcinoma Undergoing Hepatic Arterial Infusion Chemotherapy.

PROBLEM IDENTIFICATION: Postoperative comfort management for patients with hepatocellular carcinoma undergoing hepatic arterial infusion chemotherapy remains unstandardized, with fragmented evidence l...

Immunometabolic Remodeling in Ischemic and Non-Ischemic Heart Failure.

Heart failure (HF) is traditionally classified by etiology or ejection fraction, but these categories do not fully explain the mechanisms driving disease progression. Increasing evidence suggests that...

Resuscitative endovascular occlusion of the aorta restores cerebral metabolic markers of ischaemia induced by haemorrhagic shock.

BACKGROUND: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used as an adjunct in haemorrhagic shock (HS) to restore proximal perfusion. Its cerebral metabolic effects during haem...

Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.

Left atrial remodeling (LAR) critically contributes to the progression of heart failure (HF) and the development of atrial fibrillation (AF) following myocardial infarction (MI). The protein α2δ1, pri...