A Systematic Review of Modeling Platforms for Atrioventricular Valves in Atrioventricular Septal Defects.
Given the high rate of re-intervention in patients with atrioventricular septal defects (AVSD), there is a continuing need to accurately model the complex valve anatomy and surgical repair strategies....
Intra-arterial thrombolysis as adjunct to endovascular treatment in acute basilar artery occlusion.
BACKGROUND AND PURPOSE: Evidence for intra-arterial thrombolysis (IAT) after endovascular treatment (EVT) remains limited in acute basilar artery occlusion (ABAO), particularly among patients with suc...
Left ventricular mechanical dispersion in a middle-aged population: associations with subclinical cardiac remodelling and cardiovascular risk.
BACKGROUND: Heterogeneous myocardial contraction is common in myocardial disease and linked to ventricular arrhythmias, but its frequency and relevance in the general population remain unclear. This s...
Microglia-driven neuroinflammatory signaling in neurodegeneration: mechanisms and therapeutic opportunities.
Neuroinflammation has been identified as a major component to the pathogenesis and progression of many neurodegenerative illnesses, going beyond its traditional role as a protective immune response wi...
Evaluation of 3D-CRT vs. VMAT for radiotherapy of whole breast with simultaneous integrated boost.
BACKGROUND AND PURPOSE: This study evaluates volumetric modulated arc therapy (VMAT) as a potential alternative to three-dimensional conformal radiotherapy (3D-CRT) for whole-breast radiotherapy (RT) ...
Selected Retinal and Choroidal Parameters Assessed by Optical Coherence Tomography and Optical Coherence Tomography Angiography in Patients With Obstructive Sleep Apnea.
BACKGROUND The aim of this study was to assess selected retinal parameters and choroidal thickness in patients with obstructive sleep apnea. MATERIAL AND METHODS Forty-nine patients (98 eyes) were inc...
Plasma proteomics improves thrombosis prediction in patients with cancer and identifies targetable IL-17-driven endothelial activation.
Thrombosis remains a major cause of morbidity and mortality in patients with cancer. Existing risk models fail to reliably predict venous thromboembolism (VTE), underscoring the need for more accurate...
Synchronizing brains and hearts: A practical guide for caregiver-child fNIRS-ECG multimodal hyperscanning.
The study of synchrony-concordant neural, physiological, and behavioral activity between individuals-has advanced our understanding of co-regulation and socio-emotional development, particularly withi...
Mechanistic study of annular eccentricity-induced flow instability and thrombus growth in TAVI patients: a geometric sensitivity analysis.
This study investigates the potential hemodynamic penalty of post-TAVI annular eccentricity on thrombogenesis. By integrating patient-specific CTA data with a computational framework coupling multi-co...
Imaging classification of jugular bulb variants on HRCT temporal bone and CT head and neck angiography: prospective study on standardized reporting using lateral skull base landmarks and correlation with condylar vein.
Accurate imaging recognition of jugular bulb (JB) variants is essential for skull-base surgical planning and prevention of intraoperative vascular injury. This prospective study aimed to determine the...
Truncal valve repair combined with right atrial appendage valved right ventricular-to-pulmonary connection in truncus arteriosus type II with single coronary artery.
We present a challenging case of truncus arteriosus type II repair in a 2-month-old, 3.3 kg infant admitted with heart failure and cyanosis. Right ventricular-to-pulmonary arterial continuity was rest...
Damus-Kaye-Stansel procedure in the case of an anteroposterior relationship of great vessels.
This video tutorial demonstrates a Damus-Kaye-Stansel procedure performed concomitantly with a bidirectional cavopulmonary shunt in a patient with a double inlet left ventricle, malposed great arterie...
Targeting intracellular cholesterol imbalance rescues sarcomere-ER contact site signaling and ER remodeling in dilated cardiomyopathy.
Dysregulated intracellular lipid metabolism emerged as a driver of heart failure (HF), a leading cause of death worldwide that is frequently caused by dilated cardiomyopathy (DCM). Yet, how defective ...
Postnatal pulmonary artery development from transcript to tissue.
Many congenital conditions and surgical interventions perturb haemodynamics in the proximal pulmonary arteries during postnatal development, thereby altering gene expression and associated changes in ...
Micro-nanoplastics in Cardiovascular Disease: A Critical Update from Environmental Exposure to Clinical Implications.
Micro- and nanoplastics (MNPs) are emerging environmental contaminants that may contribute to cardiovascular risk. Observational human studies have reported the presence of MNPs in patients with myoca...
Hippocampal cytopathology orchestrates post-septic cognitive dysfunction.
Cognitive dysfunction induced by sepsis is a common clinical disease. The hippocampus is one of the brain regions most vulnerable to sepsis. However, the correlations between sepsis-mediated neural ce...
10-Year Randomized Outcomes of Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Aortic Stenosis.
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an established alternative to surgical aortic valve replacement for symptomatic severe aortic stenosis, but long-term, comparative clinical...
10-Year Outcomes of SAPIEN 3 Transcatheter Aortic Valve Replacement or Surgery in Intermediate-Risk Patients.
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an alternative to surgical aortic valve replacement for patients with symptomatic severe aortic stenosis. However, long-term outcomes data ...
A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.
Thin-strand pericytes cover the deepest reaches of the brain's capillary network, and their fine processes are intimately associated with adjacent endothelial cells (ECs). Recent work has revealed tha...
Percutaneous mechanical aspiration has emerged as a novel, catheter-based strategy for the management of right-sided infective endocarditis, particularly in patients with a suboptimal response to anti...