Tissue MicroRNAs in Arrhythmogenic Cardiomyopathy: A Systematic Review of Studies in Human Myocardium and Animal Models with Implications for Post-Mortem Molecular Diagnostics.

UNLABELLED: Arrhythmogenic cardiomyopathy (ACM/ARVC) is an inherited myocardial disease characterized by progressive fibro-fatty replacement, ventricular arrhythmias, and an increased risk of sudden c...

Influence of Mitral Annular Calcification Assessed by Cardiac Computed Tomography on Procedural and Clinical Outcomes of Transcatheter Aortic Valve Implantation.

Background and Objectives: Transcatheter aortic valve implantation (TAVI) is the standard therapy for patients with severe aortic stenosis at intermediate or high surgical risk. Mitral annular calcifi...

IMMUND: A Diagnostic and Therapeutic Pipeline to Uncover the Convergence in Functional Perturbation at Early Stages of Neurodegenerative Diseases and Multiple Sclerosis Based on Protein Markers.

Neuroinflammation is a key hallmark of both neurodegenerative and neurospecific autoimmune diseases, including multiple sclerosis (MS), where immune dysregulation contributes to cellular stress, autop...

Age-Related Concentric Remodeling and Sex-Dependent Dimensional Variation in Left Ventricular Geometry: A Cardiac Magnetic Resonance Study.

BACKGROUND/OBJECTIVES: Left ventricular (LV) geometry reflects structural adaptation to aging and biological sex. While cardiac magnetic resonance (CMR) provides precise morphologic assessment, most p...

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.

Cardiomyopathies are traditionally classified by structural and genetic phenotypes, but emerging evidence highlights chronic myocardial inflammation as a pivotal driver of disease progression across d...

PACAP and Maxadilan (PAC1 Agonist) Influence Plaque Progression, Migratory Ability, and Mitochondrial Morphology and Dynamics in Vascular Smooth Muscle Cells.

BACKGROUND: Pituitary adenylate cyclase-activating polypeptide (PACAP) functions as an anti-atherogenic neuropeptide. Maxadilan, a PAC1 receptor agonist, offers atheroprotection by acting downstream o...

Exosomal MALAT1 from Rapid Electrical Stimulation-Treated Atrial Fibroblasts Activates Autophagy by Downregulating miR-204-5p and Upregulating LC3B.

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is strongly associated with atrial structural remodeling driven by activated cardiac fibroblasts. Autophagy has...

The endothelial activation and stress index (EASIX) predicts hazards of short- and long-term mortality in acute ischemic stroke: a retrospective cohort study.

INTRODUCTION: Endothelial activation and stress index (EASIX) is a biomarker of endothelial dysfunction and has been validated previously as a prognostic score for mortality in various diseases, inclu...

SECmeres outperform extracellular vesicles as potential blood RNA biomarkers for Alzheimer's disease.

Cells release heterogeneous extracellular vesicles and particles (EVPs) into circulation, carrying RNA and proteins that reflect their origin. Recently, brain-derived EVs have gained significant atten...

Is endothelial dysfunction induced by aromatase inhibitors reversible after treatment?

PURPOSE: Aromatase inhibitors (AIs) are standard therapy for postmenopausal women with hormone receptor-positive breast cancer. However, prolonged AI use is associated with increased cardiovascular (C...

[Study on preoperative prediction of microvascular invasion based on contrast-enhanced ultrasound habitat imaging combined with peritumoral radiomics in hepatocellular carcinoma].

Objective: Hepatocellular carcinoma has a poor prognosis, and microvascular invasion (MVI) is an important indicator for guiding surgical decisions and influencing long-term survival. This study aims ...

The Effect of Zinc Sulfate Treatment on Diabetic Cardiomyopathy in an Aged Female Rat Model of Type 2 Diabetes.

Background/Objectives: Diabetic cardiomyopathy (DCM) is largely driven by severe oxidative stress and calcium dyshomeostasis. We examined the targeted antioxidant and therapeutic effects of zinc sulfa...

Association of Ascending Aortic Aneurysm with NOX4 and miRNA 146a.

Objective: To evaluate the efficacy of NADPH oxidase 4 and miR-146a-5p in current treatment planning for ascending aortic aneurysms, independent of aortic diameter, and to develop protocols that will ...

[Targeted inhibition of miR-503 upregulates Apelin expression to alleviate myocardial infarction in mice].

OBJECTIVES: To investigate the effect of inhibiting miR-503 on myocardial infarction (MI) and clarify its upstream regulatory factors and downstream effector pathways to identify potential therapeutic...

Computational modeling of stent failure during crimping and deployment in coronary arteries.

Crimping and deployment of coronary stents involve severe finite deformations, multibody contact, and complex loading-unloading sequences that critically influence their structural integrity and long-...

Immunomodulatory Effects of Propolis on Endothelial Cytokine Release.

Propolis is a natural resinous product with a broad spectrum of biological activities, including immunomodulatory and anti-inflammatory effects. Increasing evidence suggests that propolis may influenc...

Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis.

Autoimmune myocarditis frequently progresses to inflammatory cardiomyopathy through dysregulated immune-stromal interactions. This study employs single-nuclei RNA-sequencing (snRNA-seq) to profile 46,...

Neuroinflammation in Alzheimer's Disease (AD) and Glioblastoma (GBM): Shared Mechanisms and Therapeutic Insights.

INTRODUCTION: Neuroinflammation is a key feature of both Alzheimer's disease (AD) and glioblastoma, although it leads to different outcomes in each disorder. In AD, chronic activation of microglia and...

Protective effect of absent Hyrtl anastomosis on fetal prognosis in monochorionic twins: Report of 2 cases and literature review.

RATIONALE: Hyrtl anastomosis is an intra-arterial shunt between umbilical arteries, which exerts a protective effect by balancing arterial pressure in singleton pregnancies. Its absence may be associa...

Ultrafast ultrasound shear wave elastography: a novel approach for assessing myocardial stiffening in congenital aortic stenosis.

BACKGROUND: Congenital aortic stenosis (ConAoS) accounts for approximately 4%-8% of all congenital heart diseases. Chronic pressure overload may result in myocardial stiffening, leading to impaired ca...