Synchronous wearable ultrasound for early detection of coronary and carotid artery comorbidity.
Coronary heart disease (CHD) and carotid artery disease (CAD) often co-occur. However, conventional diagnosis typically involves separate, site-by-site examinations after symptoms appear, leading to d...
Outcomes in laparoscopic versus robotic-assisted surgery for median arcuate ligament syndrome: a systematic review and meta-analysis.
Median Arcuate Ligament Syndrome (MALS) is a rare condition caused by external compression of the coeliac artery by the median arcuate ligament (MAL), leading to postprandial abdominal pain, nausea, v...
Methodological quality of cardiac CT and MRI radiomics studies assessed using METRICS and RQS by human readers and ChatGPT 5.1 Thinking.
OBJECTIVE: To assess the methodological quality of cardiac CT and MRI radiomics studies using the METhodological RadiomICs Score (METRICS) and Radiomics Quality Score (RQS), and to evaluate inter-rate...
Pim1 Mitigates Heart Failure by Suppressing Ferroptosis Via Activation of the mTORC1/SLC7A11/GPX4 Axis.
Heart failure (HF) remains a major cause of morbidity and mortality, with ferroptosis increasingly implicated in its progression. Pim1, a serine/threonine kinase, exerts cardioprotective effects by re...
Beyond the right ventricle: left heart involvement in pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is characterized by progressive remodeling of the pulmonary vasculature, leading to increased pulmonary vascular resistance and chronic right ventricular (RV) pre...
Left ventricular non-compaction in heart failure: contemporary perspective on diagnostic challenges and treatment opportunities.
Left ventricular non-compaction (LVNC) remains one of the most debated phenotypes within the spectrum of cardiomyopathy. Increasing recognition of left ventricular hypertrabeculation (LVHT) in healthy...
Dapagliflozin confers protection against ferroptosis in cardiomyocyte via the inhibition of interferon-gamma pathway.
BACKGROUND: Ferroptosis is reported to have a role in cardiovascular disease (CVD) progression. Recent emerging evidences demonstrate the role of Sodium-Glucose Co-Transporter 2 (SGLT-2) inhibitors in...
Deciphering the potential molecular network underlying nicotine- and its metabolite cotinine-induced myocardial infarction via network toxicology, molecular dynamics, and in vitro experimental validation.
Smoking is a major modifiable risk factor for myocardial infarction (MI); however, the molecular mechanisms through which its core component nicotine and its primary metabolite cotinine mediate MI dev...
DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.
BACKGROUND: Working memory (WM) deficits are frequently observed in patients with insomnia disorder (ID), but their neural basis is unclear. Glymphatic dysfunction and disrupted structural-functional ...
Noninvasive whole-brain imaging of glymphatic dynamics.
Cerebrospinal fluid circulation through the glymphatic system plays a crucial role in removing metabolic waste from the central nervous system. However, the mechanism underlying the brain-wide glympha...
Life-span-dependent transcriptional dynamics of the human heart.
The human heart undergoes continuous transcriptional remodeling from development through aging, yet the cellular and regulatory features governing this process remain incompletely defined. Here, we ge...
Dysfunction of endothelial cells manifests early in pulmonary arterial hypertension and represents a critical therapeutic target. Nevertheless, the limited efficacy of single-target interventions unde...
Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis by undergoing phenotypic modulation from a quiescent, contractile state to a range of synthetic phenotypes, including fibrob...
Cardiac fibrosis is a major cause of cardiac dysfunction and is associated with virtually all forms of heart disease. Recently, single-cell genomic approaches have revealed in unprecedented resolution...
SIRT1 (sirtuin 1), a nicotinamide adenine dinucleotide-dependent protein deacetylase, regulates cardiovascular inflammation by modulating cellular stress, inhibiting NLRP3 (NLR family, pyrin domain-co...
Thrombosis is a major contributor to morbidity and mortality in cardiovascular diseases. Although current antiplatelet therapies reduce thrombotic complications, they are associated with systemic blee...
Macrophages are key players in the pathogenesis of atherosclerosis. They trigger immune responses through their cell-surface receptors. However, how macrophages regulate those receptors in response to...
Long-term impact of haemorrhoidal artery ligation on anal function and continence.
AIMS: Haemorrhoidal artery ligation (HALO) and variants including Doppler-guided HAL (DG-HAL), HAL with rectoanal repair (HAL-RAR), and transanal haemorrhoidal dearterialisation (THD) serve as minimal...
The emerging role of the meningeal lymphatic and glymphatic systems in migraine pathophysiology: a systematic review.
BACKGROUND/OBJECTIVE: Migraine is a common, debilitating neurological disorder of unclear pathophysiology. Recent evidence has implicated impaired meningeal lymphatic function and its interaction with...
CFD-driven optimization and experimental validation of venturi-based thrombectomy devices in a circle of willis.
The geometry of the Circle of Willis poses major challenges for mechanical thrombectomy, where device navigability and effective thrombus removal determine treatment success. This study investigated t...