Matrix Metalloproteinase-9-Responsive Lipid-Core Micelles for Proof-of-Concept Enzyme-Triggered Cardiomyocyte Association.
Cardiovascular diseases (CVDs) remain the leading cause of global mortality and are frequently associated with increased matrix metalloproteinase-9 (MMP-9) activity during cardiac remodeling and infla...
Algorithm-based quantification of tissue vascularization in immunohistochemical stainings of tissue sections.
The vascular system ensures sufficient blood supply and tissue homeostasis and consists of different cell types. Endothelial cells represent the structural backbone of blood vessels and are accompanie...
Engineering an AIEgen-based platform integrating CRISPR/Cas9 to remodel the tumor microenvironment and reinforce photo-immunotherapy against glioblastom.
Glioblastoma remains one of the most lethal brain tumors. Although immunotherapy and other therapeutic modalities has achieved significant therapeutic success in several malignancies, its efficacy in ...
Impaired Glymphatic Function and Post-stroke Cognitive Decline after Intracerebral Hemorrhage: A Serial Neuroimaging Study.
After an intracerebral hemorrhage (ICH), impaired glymphatic function (GF) can result in neurotoxin buildup in the brain. In this serial MRI imaging study, we investigated the association between impa...
Stent placement as rescue treatment in acute basilar artery occlusion.
INTRODUCTION: We investigated the etiology, safety and efficacy of endovascular treatment with and without stent placement as rescue treatment in patients with acute ischemic stroke due to basilar art...
HMGB1 promotes intracranial aneurysm progression by regulating vascular smooth muscle cell phenotypic switching and ferroptosis.
Phenotypic switching in vascular smooth muscle cells (VSMCs) is key to the formation and progression of intracranial aneurysms (IAs). High-mobility group box 1 (HMGB1), a damage-associated molecule, s...
Optimising patient selection for adrenal vein sampling in primary aldosteronism: role of biochemical markers and scoring systems.
BACKGROUND: Adrenal vein sampling (AVS) is the gold standard for subtyping primary aldosteronism (PA), but the role of adrenocorticotropic hormone (ACTH) stimulation during this procedure remains deba...
Large Animal Models of Tricuspid Regurgitation: Relevance, Limitations, and Future Directions.
Despite growing interest in tricuspid regurgitation (TR), evidence remains insufficient to define the optimal timing of intervention and therapeutic strategies, highlighting the need for robust experi...
The enigmatic occipital emissary vein, foramina, and canals: anatomical study with application to skull base surgery.
Compared with mastoid emissary veins, occipital emissary veins have been less studied, and published descriptions of their foramina are inconsistent. This anatomical investigation aimed to clarify the...
A Age Related Vascular Senescence: Mystery of Blood-brain Barrier Dysfunction in Neurodegeneration.
The pathophysiology of neurodegenerative illnesses is increasingly understood to be influenced by vascular aging, with blood-brain barrier (BBB) disruption emerging as a crucial mechanistic connection...
[A double-island flap based on the lateral circumflex femoral artery for soft tissue reconstruction after radical resection of advanced oral and oropharyngeal cancer].
Objective: To report the surgical strategy for harvesting a double-island flap based on the lateral circumflex femoral artery (LCFA) for reconstruction of complex soft tissue defects following radical...
Hemorrhagic Myocardial Infarction and Intramyocardial Hemorrhage: From Microvascular Damage to Emerging Therapeutic Targets.
Intramyocardial hemorrhage (IMH) is a severe form of post-ischemic microvascular injury that may occur after myocardial infarction, particularly in the setting of extensive ischemia and reperfusion. I...
Percutaneous Transcatheter Embolization for Recurrent Cerebral Embolism Due to Pulmonary Arteriovenous Malformation.
BACKGROUND Pulmonary arteriovenous malformations (PAVMs) are rare structural vascular abnormalities that create communications between pulmonary arteries and veins, resulting in right-to-left shunts. ...
PAP Versus DIEP Flap Breast Reconstruction: Current Evidence and the Unresolved Question of Timing and Oncologic Safety-A Narrative Review.
Background/Objectives: Deep inferior epigastric perforator (DIEP) flap reconstruction represents the gold standard for autologous breast reconstruction, while profunda artery perforator (PAP) flap rec...
Investigation of catheter navigation through flexible intracranial vessel: a combined in silico and in vitro study.
Trackability of thrombectomy catheters through tortuous cerebral vessels is a key determinant of mechanical thrombectomy success, particularly for large-bore aspiration catheters. Yet, the underlying ...
Convergent blood-brain barrier breakdown in schizophrenia and autism spectrum disorders: a systematic review of preclinical animal models.
BACKGROUND: Schizophrenia (SCZ) and autism spectrum disorder (ASD) are neurodevelopmental disorders with multifactorial origins involving genetic and environmental risk factors. Both conditions share ...
Blood-Ocular Barrier Dysfunction in Uveitis: A Bidirectional Model Linking Pathogenesis, Clinical Monitoring, and Therapeutic Opportunities.
Uveitis is a heterogeneous group of intraocular inflammatory diseases and an important cause of visual impairment worldwide. Although current treatments mainly target inflammation, many patients devel...
Thyroid Artery Flow Velocity and Serum Adenosine Deaminase After Methimazole Therapy in Autoimmune Hyperthyroidism.
Autoimmune hyperthyroidism, including Graves' disease and Hashimoto's hyperthyroidism, presents with overlapping biochemical features but distinct pathophysiological mechanisms. Non-invasive methods t...
Aconitine Induces Myocardial Damage in Rats Associated With Activation of the JNK1/2 Signaling Pathway.
Acute Aconitine (Acon) poisoning can cause arrhythmia and myocardial damage; however, the underlying mechanisms remain unclear. This study investigated the mechanism of myocardial injury induced by ac...
Mid-term results of bicuspid aortic valve repair with a new technique, the Ozbek procedure.
INTRODUCTION: Aortic valve insufficiency has been reported in approximately one-third of patients with a bicuspid aortic valve (BAV). In this study, we describe a new use of an old aortic repair techn...