Case report: unilateral varicose veins.
A healthy 69-year-old man presented to the cardiovascular surgery outpatient department with a 20-year history of right leg swelling and varicose veins (Figure A). He denied experiencing resting pain ...
Case report: unilateral varicose veins.
A healthy 69-year-old man presented to the cardiovascular surgery outpatient department with a 20-year history of right leg swelling and varicose veins (Figure A). He denied experiencing resting pain ...
Coronary Artery Calcification: From Molecular Mechanisms to Interventional Strategies.
Coronary artery calcification (CAC) represents a clear sign of advanced atherosclerosis and a strong indicator of coronary artery disease burden and cardiovascular risk. Beyond its established prognos...
The bidirectional mechanistic links between Alzheimer's disease and cardiovascular disease.
BACKGROUND: Alzheimer's disease (AD) and cardiovascular disease (CVD) are two significant chronic diseases that have a profound impact on the health of the elderly globally. In recent years, an increa...
Cardiac Lipid Metabolism: Cells, Metabolites, and Rhythms.
Although studied for decades, metabolic therapies that target cardiac lipid metabolism are underdeveloped, and most approaches have thus far failed as a heart failure treatment. In contrast, new thera...
Functional Changes in Mitochondrial Subpopulations of Left Ventricular Cardiomyocytes in Post-Infarction Rats During the Subacute Stage of Remodeling.
BACKGROUND: Cardiovascular diseases remain a leading cause of mortality worldwide, with myocardial infarction (MI) being the most severe form. Despite advances in treatment, MI is still associated wit...
Contemporary Endothelial Genome Editing Technologies: Towards Precision Genetic Medicine for Vascular Diseases.
Endothelial dysfunction is a key characteristic of many diseases, including atherosclerosis, hypertension, heart failure, stroke, cancer, acute respiratory distress syndrome (ARDS), peripheral vascula...
Angiotensin-Converting Enzyme 2 Overexpression Protects Heart from Aging-Induced Injury in C57BL/6 Mice.
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally among older adults. Similar to humans, age-related declines in cardiac function are observed in C57BL/6 mice. Angiot...
Long-term outcomes of venous graft preservation in a rat autologous transplant model.
Venous grafts remain the most used conduits in coronary artery bypass grafting (CABG) but are highly susceptible to early failure due to ischemia-reperfusion injury, intimal hyperplasia, and accelerat...
Paclitaxel-coated balloon treatment is associated with sympathetic coronary denervation in a porcine model.
Drug-coated balloon (DCB) therapy promotes beneficial vascular remodeling after percutaneous coronary intervention. However, its mechanisms remain elusive. Given paclitaxel's neurotoxicity, the effect...
Dl‑3‑n‑Butylphthalide Protects the Blood-Brain Barrier in Neonatal Hypoxic‑Ischemic Brain Damage by Alleviating Endothelial Cell Ferroptosis via the SLC7A11/GSH/GPX4 Pathway.
Hypoxic-ischemic brain damage (HIBD) is a major contributor to neurological disabilities. Our previous studies have demonstrated that DL-3-n-butylphthalide (NBP) confers protective effects against HIB...
Transcriptomic characters of cochlear vascular cells with pericyte-driven angiogenetic activity.
The normal structure and function of inner-ear blood vessels, including the microvascular network of the stria vascularis (SV) within the blood-labyrinth barrier (BLB), are essential for auditory func...
Cytocompatible liquid crystal elastomer fibers for potential application as artificial skeletal or cardiac muscle.
To biomimetically mimic native muscle tissue new artificial soft actor materials need to be developed that can be processed into fibers and combine high mass-specific work, a sufficiently high contrac...
Modulation of depression through the neurobiological underpinnings of the glymphatic-rumination relationship.
BACKGROUND: Glymphatic functioning is implicated in cognitive and affective functioning. Given that rumination, a major risk factor for major depressive disorder (MDD), is a cognitive process regulati...
HDAC inhibition reprograms stem cell fate to suppress infantile hemangioma vasculogenesis.
Infantile hemangioma (IH), the most common vascular tumor of infancy, relies on hemangioma stem cells (HemSCs) to drive pathological vasculogenesis during the proliferating phase. While beta-blockers ...
Immunomodulatory Effects of Volatile Anesthetic Sevoflurane on Cardiomyocytes after Coronary Artery Bypass Grafting: Insights from Bioinformatics Analysis.
Volatile anesthetics, particularly sevoflurane, have demonstrated cardioprotective properties during cardiac surgery. However, their immunomodulatory mechanisms at the molecular level remain unclear. ...
Temporal Orchestration of Krüppel-like Factors During Cardiac Remodeling Following Isoproterenol-Induced Myocardial Injury.
Background: Myocardial infarction triggers a complex remodeling process involving inflammation, hypertrophy, fibrosis, and electrical adaptation, ultimately predisposing the heart to failure. Krüppel-...
Retinal microvascular alterations consistent with endothelial dysregulation in paediatric post-COVID-19 syndrome: A prospective matched-cohort study.
Persistent symptoms following SARS-CoV-2 infection in children remain poorly understood, and objective biological correlates are scarce. The vascular endothelium is considered a central target of post...
Symptomatic branch retinal artery occlusion as a presenting sign of carotid artery occlusion.
A man in his late 60s with a history of arterial hypertension, dyslipidaemia and a cerebrovascular accident 20 years ago presented to the emergency department with sudden-onset blurred vision in his r...