A monolithic patient-specific 3D-0D model for In silico investigation of hemodynamics in patients with left ventricular assist devices.

We present a fully coupled, patient-specific 3D-0D computational framework for hearts supported with left ventricular assist devices (LVAD) that enables controlled in silico experimentation. The appro...

A data-driven computational methodology for assessing ventricular ablation procedures.

Ventricular tachycardia following myocardial infarction is often sustained by complex reentrant circuits that are challenging to characterize and treat using conventional electroanatomical mapping. Co...

Treadmill Exercise Alleviates Motor Deficits of PD Mice via Regulating STING-Mediated Valeric Acid-Th17/Treg-IL-17A Axis.

The objective of this study is to investigate the effects of treadmill exercise on motor deficits in chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced chronic Parkinson'...

Pituicyte-derived TGFβ2 regulates Col15a1 expression in pericytes of the rat posterior pituitary.

The posterior lobe (PL) of the pituitary contains a specialized neurovascular junction, where neurosecretory axon terminals closely associate with fenestrated capillaries to enable efficient hormone r...

Integrative analysis of bulk and single-nucleus transcriptomes suggests proteostasis- and metabolism-related alterations in the right ventricular outflow tract of non-syndromic Tetralogy of Fallot.

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease, among which non-syndromic TOF (nsTOF) represents the most common subtype; however, the molecular mechanisms underlying r...

PSAP Protects Against Acute Myocardial Ischemia-Reperfusion Injury by Promoting ASAH1-Mediated Ceramide Metabolism.

Myocardial ischemia-reperfusion (I/R) injury remains a leading cause of cardiovascular morbidity. However, due to the unclear underlying molecular mechanisms, effective therapeutic approaches are stil...

Terminal branching pattern of posterior tibial artery in the tarsal tunnel: a cadaveric study with its clinical importance in medial ankle surgeries.

PURPOSE: The posterior tibial artery (PTA) branching within the tarsal tunnel is subject to significant anatomical variation, which can complicate surgical procedures such as tarsal tunnel decompressi...

Emergency access to the subclavian vessels by non-thoracic surgeons: a cadaver-based learning model for orthopedic trauma surgery.

PURPOSE: The aim of this study was to evaluate the procedural time and safety of an infraclavicular approach to the subclavian vessels for damage control of major upper extremity vascular injuries. Th...

Modification of a poroelastic model for zero porosity: finite element implementation and investigation of fluid mechanics in the perivascular space.

In conventional formulations of poroelasticity, when the porosity approaches zero or vanishes in some parts of the poroelastic domain, if only temporarily, the governing equations degenerate to those ...

Transjugular Transcatheter Tricuspid Valve Implantation of Coronary Stent System for Creating a Rat Tricuspid Regurgitation Model.

We aimed to establish a rat TR model to further investigate the mechanisms of right heart remodeling and organ damage induced by TR. Intervention group rats (n = 6) underwent coronary stent system imp...

Atrial cardiomyopathy as a multidomain disease: longitudinal evidence for autonomic remodelling.

AIMS: Atrial cardiomyopathy (AtCM) is increasingly recognized as a substrate for atrial fibrillation (AF), yet its operationalization remains limited and largely marker-driven. Whether autonomic remod...

Catheter ablation of atrial fibrillation in transthyretin and light-chain cardiac amyloidosis: results from the multicentre AMYL-AF study.

AIMS: Atrial fibrillation (AF) is highly prevalent among cardiac amyloidosis (CA) patients and contributes significantly to their morbidity and mortality. Evidence regarding AF ablation efficacy and s...

In Utero Fetal Lamb Model of Mitral Inflow Obstruction To Induce Hypoplastic Left Heart Syndrome-like Physiology.

Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect characterized by underdevelopment of the left ventricle (LV), mitral valve, aortic valve, and ascending aorta. Based on the "...

The peptide ACTY116 improved noradrenaline-induced cardiac hypertrophy and enhanced cardiac function by biasing receptor signaling toward the β-arrestin and against the Gαq protein.

OBJECTIVES: Myocardial hypertrophy, is a major precursor to heart failure, is characterized by a lack of targeted therapeutic efficacy. ACTY116, investigated by our group, is a novel peptide designed ...

CLARISA: Connexin-43 Lateralization Automated ROI-Based Image Signal Analyzer.

Connexin-43 (CX43) lateralization in ventricular myocardium has been associated with abnormal impulse propagation and increased arrhythmia susceptibility. Its quantitative assessment in histological s...

Atrial resynchronization: an overlooked concept in heart failure and conduction system pacing: review of selected literature with emphasis on atrial anatomy.

AIMS: Unlike ventricular electrical disease, the impact of similar atrial disease on cardiac function has received insufficient importance. We aimed to examine data on atrial anatomy, electrical disea...

Exosome mimetic nanoparticles for siRNA based targeting of α-synuclein and neuroinflammation in Parkinson's disease.

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder caused by degeneration of dopaminergic neurons and accumulation of α-synuclein protein, leading to sustained neuroinflammation. OBJ...

Computational imaging of cardio-magnetic sources: reconstruction of time-varying dipoles and epicardial potentials from magnetocardiography.

The electrical activities in living tissues are caused by ionic movements along cell membranes, particularly in excitable tissues like neurons, cardiac cells, and skeletal muscles. The heart muscles p...

MOTS-c preserves mitochondrial subpopulation bioenergetics and genome integrity to attenuate cardiac ischemia reperfusion injury.

BACKGROUND: Mitochondrial dysfunction contributes substantially to myocardial ischemia-reperfusion (IR) injury through impaired bioenergetics, oxidative stress, and disruption of mitochondrial homeost...

Lysophosphatidic Acid Reduces Ischemic Brain Injury by Attenuating Vascular Permeability Through LPA4 Receptor Signaling.

Blood-brain barrier (BBB) disruption significantly exacerbates secondary injury following ischemic stroke. Although lysophosphatidic acid (LPA) is known to regulate vascular stability, its specific ro...