AI-based Histologic Heterogeneity of Microvascular Obstruction at Cardiac MRI for Predicting MACEs: A Multicenter Study.
Background Microvascular obstruction (MVO) is strongly associated with adverse outcomes after ST-segment elevation myocardial infarction (STEMI). However, manual quantification of MVO is time-consumin...
Cerebral air embolism from oesophageal-pulmonary vein fistula induced by fish bone ingestion.
Fish bone ingestion is common, but cerebral air embolism as a secondary complication is exceedingly rare. A man in his 80s presented to our tertiary emergency centre after sudden collapse following oe...
Automated Centerline Extraction From Meshed Vascular Models.
Centerlines of vascular structures are essential for the analysis of vascular anatomy as well as the development of computational models for simulating biomechanics. In this paper, we present a center...
Engineered Pericyte-Targeted Extracellular Vesicles Protect Against Hypoperfusion-Induced Cognitive Impairment and Vascular Demyelination.
Pericyte dysfunction is an early hallmark of vascular cognitive impairment (VCI), yet targeted therapies remain limited. Here, we develop a bio-orthogonal approach to engineer extracellular vesicles (...
Retinal vasculature-derived proteins serve as potential systemic biomarkers for diabetic retinopathy.
PURPOSE: Fibrovascular membrane (FVM), a pathological tissue causing retinal traction, represents an advanced stage of proliferative diabetic retinopathy (PDR). This study aimed to identify novel prot...
Retinal Ischemic Perivascular Lesions Screen for Vision-Threatening Diabetic Retinopathy Visualized on Ultra-Widefield Fluorescein Angiography.
PURPOSE: To validate retinal ischemic perivascular lesions (RIPLs) as an optical coherence tomography (OCT) biomarker for vision-threatening diabetic retinopathy (VTDR), using ultra-widefield fluoresc...
Niacin Ameliorates EHDPHP-Induced Oxidative Stress and Mitochondrial Dysfunction in H9C2 Cells.
2-Ethylhexyl diphenyl phosphate (EHDPHP) is a widely used organophosphorus flame retardant frequently detected in environmental matrices and poses potential health risks. However, its cardiotoxic effe...
Mastoid emissary vein, mastoid emissary foramen, and mastoid emissary canal: anatomy, variability, imaging, and clinical implications.
PURPOSE: The mastoid emissary vein (MEV), mastoid emissary canal (MEC), and mastoid emissary foramen (MEF) are common but variably reported structures of the mastoid-posterior fossa region. Existing l...
The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder with a complex pathophysiological mechanism and a marked sex difference in prevalence and disease severity, with women being more a...
Anatomic variations uncommon variant of the callosomarginal artery originating from A1 segment of the anterior cerebral artery with an unruptured aneurysm and distal A1 fenestration.
Some anatomical variations in the A1 segment of the anterior cerebral artery have been reported, but large cortical branches arising from this A1 segment are rare. Herein, we report an unusual case of...
Mural cells protect the adult brain from hemorrhage but do not control the blood-brain barrier in developing zebrafish.
The blood-brain barrier (BBB) protects the brain from circulating metabolites and plays central roles in neurological diseases. Endothelial cells (ECs) of the BBB are enwrapped by mural cells includin...
Early outcomes of redo-TAVI with the SAPIEN 3 platform: the prospective, multicentre ReTAVI registry.
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is increasingly performed in younger and lower-risk patients. Since many of these patients will outlive their transcatheter heart valve (THV)...
TAVI and coronary interventions: indications, technical considerations, and clinical scenarios.
Transcatheter aortic valve implantation (TAVI) has become the preferred treatment for severe aortic stenosis. Nonetheless, interplay between aortic valve disease, transcatheter valve implantation, and...
Early Effect of Transradial Coronary Angiography on Radial Artery Diameter.
OBJECTIVE: To determine whether there is any change in ipsilateral radial artery (RA) diameter following access for transradial coronary angiography and to assess any gender-related association with p...
Prenatal differential diagnosis of pseudo-COA.
BACKGROUND: The prevalence of coarctation of the aorta is 4/10,000, accounting for 8% of congenital heart diseases. Accurate prenatal diagnosis of coarctation of the aorta is still difficult. CASE PRE...
Mechanical heart valve replacement necessitates long-term warfarin anticoagulation to prevent thromboembolic complications, yet achieving adequate anticoagulation control remains challenging. This stu...
The aim of this study was to evaluate real-world rivaroxaban safety and adherence in patients with nonvalvular atrial fibrillation (NVAF). A prospective, observational, cohort, postmarketing study was...
We appreciate the thoughtful commentary by Drs. Dziewierz and Siudak regarding our study comparing tirzepatide versus semaglutide in post-CABG diabetic patients. While we acknowledge the inherent limi...
The evolving cardiovascular burden in Sierra Leone: a 33-year analysis of the Global Burden of Disease study 2023
To quantify trends in stroke, ischaemic heart disease (IHD), and hypertensive heart disease (HHD) in Sierra Leone from 1990 to 2023 using Global Burden of Disease (GBD) Study 2023 estimates. We analyz...
Transcatheter edge-to-edge repair (TEER) has emerged as an important therapy for severe mitral regurgitation. Current guidelines lack evidence-based recommendations for optimal postprocedural antithro...