Effect of adjuvant transarterial chemoembolization on survival in hepatocellular carcinoma with microvascular invasion: a landmark analysis.

BACKGROUND: The prognostic significance of adjuvant transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) remains controversial. Furthermo...

Left Ventricular Strain-Volume Loops in a Healthy Population: The Role of Sex and Age.

BACKGROUND: By combining left ventricular (LV) global longitudinal strain (GLS) with LV volume during the cardiac cycle, LV strain-volume loops (SV-loops) can be generated. LV SV-loop derived paramete...

Robotic portomesenteric vein reconstruction using self-fashioned bovine pericardial grafts during Da Vinci-assisted pancreatectomy: a case series with video demonstration.

BACKGROUND: In pancreatic cancer surgery, portomesenteric vein involvement can limit resectability and local tumor control, adversely affecting prognosis. While vascular reconstruction with bovine per...

Histopathological and duplex characteristics of deep venous stents: A novel microsurgical small animal model.

BACKGROUND: Venous stent preclinical testing typically uses large animal models. We created two models of infrarenal inferior vena cava (IVC) stenting to study patency, flow rate, wall shear stress, a...

Transcriptomic profiling of varicose veins and associated blood biomarkers.

BACKGROUND: Intervention for patients with symptomatic varicose veins is largely driven by a combination of symptoms, the magnitude of venous reflux, clinical severity scoring algorithms, and unrespon...

Avermectin disrupts blood-brain barrier integrity in zebrafish larvae via the Wnt/β-catenin signaling pathway.

Avermectin, a widely used insecticide, has raised widespread concern over its potential toxic risk to non-target organisms. The safety of the nervous system occupies a crucial position in pesticide ri...

Influence of Fiber Dispersion Representation on the Accuracy of the Mechanical Response of Healthy and Aneurysmal Aortic Wall Tissue.

This study investigates the influence of fiber dispersion representation on the accuracy of the mechanical response of anisotropic hyperelastic material models for healthy and aneurysmal human aortic ...

Modulation of Systemic Osmolarity Alters Retinal Thickness and Schisis Cavities Without Blood Retinal Barrier Disruption in Rs1 Knockout Mice.

PURPOSE: The purpose of this study was to determine whether systemic osmolarity modulation through dehydration or hydration alters retinal thickness and schisis cavity area in Rs1 knockout (KO) mice c...

Clinical outcomes of middle meningeal artery embolization in trauma-related chronic subdural hematoma.

BACKGROUND: Middle meningeal artery (MMA) embolization has emerged as a promising therapeutic option in the management of chronic subdural hematoma (cSDH). However, data specifically focusing on traum...

Short-Term Effects of Optically Induced and Digitally Simulated Myopic Blur on Retinal Perfusion: Insights From Optical Coherence Tomography Angiography.

PURPOSE: To examine changes in retinal perfusion density (PD) following short-term exposure to optically induced myopic defocus, an ocular growth-inhibitory stimulus, and achromatic digitally simulate...

Impact of geometric factors and shear stress on endothelial function: Hemodynamic insights from human cerebral arterial bifurcations.

Vascular inflammation is not a random biological event but rather a process that is strictly regulated by physical forces. While biochemical mediators are well characterized, the local physical mechan...

Nanoparticles in Vascular Dementia: Advantages and Challenges.

BACKGROUND: Vascular dementia (VaD) is the second most prevalent form of dementia, accounting for 15%-20% of dementia cases and is primarily caused by cerebrovascular disorders. Current treatments pre...

Selective loss of Cx40 and conduction abnormalities underlie enhanced atrial fibrillation susceptibility in a HFpEF model in male mice.

Heart failure with preserved ejection fraction (HFpEF) is frequently complicated by atrial fibrillation (AF), yet the mechanisms underlying AF vulnerability prior to or independent of extensive struct...

Coronary Artery Ectasia: A 10-Year Experience at a Single Center in Saudi Arabia.

OBJECTIVE: To assess the incidence of coronary artery ectasia (CAE) and its associated clinical characteristics and outcomes over a long follow-up period in Saudi Arabia. METHODS: We retrospectively a...

Double-Stranded DNA Sensing cGAS-STING Immune Signaling in a Rat Co-Culture Model of the Blood-Brain Barrier.

Double-stranded DNA coming from, for example, viruses, bacteria, or apoptotic cells is recognized by the cGAS-STING signaling pathway comprising the cyclic GMP-AMP synthase (cGAS) and the stimulator o...

Assessment of Right Atrial Function in Patients With Chronic Thromboembolic Pulmonary Hypertension.

BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) leads to right atrial (RA) dysfunction, which correlates with poor prognosis. However, most studies on RA function in pulmonary hypert...

Noninvasive Left Ventricular Pressure-Strain Loop for Evaluating Changes in Left Ventricular Function in Colorectal Cancer Patients After Chemotherapy.

OBJECTIVE: To noninvasively monitor cardiac functional changes throughout chemotherapy in colorectal cancer patients using pressure-strain analysis, validate their predictive value for early detection...

Inflammation-Associated Microvascular Dysfunction in Polymyalgia Rheumatica: Reversible Capillary Impairment Documented in an Older Patient.

Longitudinal nailfold videocapillaroscopy in an older patient with polymyalgia rheumatica shows reduced capillary density during active disease and restoration after glucocorticoid therapy, supporting...

Association of Mitral Annular Disjunction on Magnetic Resonance Imaging With Cardiovascular Outcomes.

BACKGROUND: Mitral annular disjunction (MAD) is increasingly recognised on cardiac magnetic resonance (CMR) imaging, yet its clinical significance remains under discussion. We aimed to determine the p...

Massive upper gastrointestinal haemorrhage from splenic artery erosion secondary to gastro-gastric fistula following single-anastomosis gastric bypass.

A woman in her 40s presented with massive upper gastrointestinal bleeding a few months after undergoing a single-anastomosis gastric bypass. CT abdomen and pelvis showed a marginal ulcer with adjacent...