Correspondence: Life’ s Essential 8 and cardiovascular health: Protective effects on chronic respiratory diseases
Correspondence: Life’ s Essential 8 and cardiovascular health: Protective effects on chronic respiratory diseases
Beyond AUC: Questioning the clinical interpretation of “superior” discrimination in cardiovascular health scores
Standard modifiable risk factors (SMuRFs), including hypertension, diabetes, hyperlipidaemia, and smoking, are prevalent among patients undergoing percutaneous coronary intervention (PCI). This study ...
Heart failure-related cardiogenic shock (HF-CS) is now the leading etiology of cardiogenic shock (CS). Advances in temporary mechanical circulatory support (tMCS), particularly microaxial flow pumps (...
Hydroxysafflor Yellow A Regulates SIRT1-FOXO3-BNIP3 Signaling Pathway to Promote Mitophagy: A Novel Therapeutic Strategy for Myocardial Ischemia-Reperfusion Injury.
BACKGROUND: Hydroxysafflor Yellow A (HSYA), the major bioactive component from Carthamus tinctorius L., exerts significant protective effects against myocardial ischemia-reperfusion injury (MIRI). Mit...
Effect of a Very-Low-Protein Diet Supplemented with Ketoacid Analogues on Arteriovenous Fistula Maturation and Endothelial Function: A Prospective Observational Study.
BACKGROUND: Arteriovenous fistula (AVF) maturation is a critical determinant for successful hemodialysis in patients with end-stage renal disease (ESRD). Endothelial dysfunction and arterial stiffness...
Development of an Integrated CE-Cell-SELEX Strategy for Rational Selection of Human Bone Microvascular Endothelial Cell Aptamers.
Capillary electrophoresis (CE) has proven to be an effective technique for aptamer selection. Here, we directly integrated the separation advantages of CE into a live-cell system, thereby establishing...
Single-Nucleus Profiling Reveals a BBB Senescence Unit Driving AD Pathology in Human Brain.
Cellular senescence contributes to Alzheimer's disease (AD) and involves the neurovascular unit, but the molecular mechanisms of cellular senescence in AD pathogenesis remain incompletely understood. ...
TASC-SwinMT: Task-Adaptive Synergistic Cross-Task Swin Multi-Task Framework for CT and MRI Image Interpolation and Segmentation.
Background: Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) interpolation and segmentation are critical for clinical diagnosis, anatomical quantification and personalized treatment. Most...
Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy.
Thirteen new decaline polyketides, namely, zosteropenillines T-W (1-4), 8-hydroxypallidopenilline A (5), 13-epi-zosteropenilline P (6), 11-epi-zosteropenilline N (7), 15-hydroxyzosteropenilline M (8),...
The Heart Rhythm Society statement on the Reliance high-impedance advisory recommended shared decision-making regarding lead management decisions given concerns of risk associated with extraction from...
Transtail Artery Hepatic Artery Catheterization In Rats Under Direct Vision: A Radiation-Free Method For Establishing Animal Models.
Rat liver tumor models are indispensable for studying trans-arterial chemoembolization (TACE), drug delivery, and tumor biology. However, conventional techniques utilizing fluoroscopy-guided carotid o...
Arrhythmias and Coronary Slow Flow: A Potential Pathogenic Link.
Coronary slow flow (CSF) is characterized by recurrent resting angina and delayed distal vessel filling, despite the absence of obstructive coronary artery disease on angiography. With the continuous ...
Temporal RT-qPCR-Based Porcine Cardiac Molecular Profiling for Post-Mortem Interval Estimation: Predictive Modeling.
Estimating the post-mortem interval (PMI) remains a major challenge in forensic pathology, particularly beyond the earliest postmortem phases. RNA-based markers measured by RT-qPCR have been proposed ...
Bioinformatics Identification and Molecular Docking Validation of Post-Translational Modification-Related Hub Genes as Diagnostic Biomarkers and Therapeutic Targets in Myocardial Fibrosis.
Myocardial fibrosis is a common pathological feature of multiple cardiovascular diseases, including heart failure, hypertension, and myocardial infarction, and is associated with poor prognosis. Despi...
Sudden cardiac death (SCD) is a major public health problem worldwide. Despite many advances in the care of sudden cardiac arrest (SCA), 90% of individuals with SCA do not survive. A major challenge i...
Introduction of the three-vessel trachea view to the second trimester foetal anomaly screening programme increased detection of right (RAA) and double (DAA) aortic arch. Aim was to investigate inciden...
Effect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomized Clinical Trial.
Background: Post-COVID-19 syndrome is associated with endothelial dysfunction (ED) and various sequelae, particularly in individuals who experienced critical illness during the acute phase, affecting ...