Heart-Type Fatty Acid-Binding Protein (H-FABP) as a Candidate Adjunctive Biomarker for Immune Checkpoint Inhibitor-Related Cardiotoxicity: Linking Early Immune-Metabolic Myocardial Injury with Translational Cardio-Oncology.
Immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of oncology but are increasingly associated with cardiovascular immune-related adverse events (irAEs), including myocardi...
Evidence linking arrhythmias to dementia predominantly focuses on atrial fibrillation/flutter (AF), leaving non-AF subtypes under-researched. This study investigated associations of multiple incident ...
After acute coronary syndrome (ACS), high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) levels have been associated with risk of major adverse cardiovascular events (MACE). Whether t...
Redefining Primary Aldosteronism.
Journal of the American College of Cardiology
Chimeric antigen receptor T-cell (CAR-T) therapies are cellular immunotherapies that improve survival in patients with relapsed haematologic malignancies. However, their association with major adverse...
A size-adjustable cryoballoon (SACB, POLARxFIT), switching between 28-mm and 31-mm diameters, was introduced for atrial fibrillation (AF) ablation; however, its efficacy and safety compared with conve...
Pulsed field ablation (PFA) has reshaped atrial fibrillation (AF) ablation landscape, yet the relative advantages and limitations of currently available catheter ablation energy modalities-radiofreque...
Atrial Fibrillation in Infiltrative Cardiomyopathies: From Atrial Cardiomyopathy Imaging to Targeted Management-A Narrative Review.
Infiltrative cardiomyopathies comprise a heterogeneous spectrum of hereditary and acquired diseases characterised by the accumulation of pathological substrates within the myocardium, ultimately resul...
[Advances in the application of manganese dioxide nanomaterials in the treatment of glioblastoma].
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor of the central nervous system. Its treatment is greatly limited due to the presence of the blood-brain barrier (BBB),...
In patients with myocardial infarction (MI), no heart failure, and left ventricular ejection fraction (LVEF) ≥ 40%, the combined BETAMI-DANBLOCK trial showed that beta-blockers reduced the risk of all...
Loss-of-function variants in KCNH2, which encodes hERG, are responsible for long QT syndrome type 2 (LQT2), a major cause of sudden cardiac death. Most hERG pore-domain missense variants are associate...
Atrial fibrillation (AF) is an independent risk factor for dementia.
Serum Galectin-3 Levels Correlate with Reduced Vascular Reactivity in Patients with Coronary Artery Disease.
Background and Objectives: Endothelial dysfunction is essential in the development and progression of coronary artery disease (CAD) and its complications. Galectin-3 mediates inflammation and organ fi...
Functional Pathological Features and Molecular Markers in Alzheimer's Disease.
Alzheimer's disease (AD) is a neurodegenerative disorder defined not only by amyloid-β plaques and tau pathology but also by several interacting processes that drive disease progression. These include...
Current guidance recommends better low-density lipoprotein cholesterol (LDL-C) control in patients with elevated lipoprotein(a) [Lp(a)] as Lp(a) lowering therapies are unavailable. Whether risks attri...
Magnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.
Magnesium (Mg) is an essential divalent cation involved in more than 600 enzymatic reactions and plays a fundamental role in vascular, metabolic, and neural homeostasis. Although Mg is frequently disc...
Association Between Hemoglobin Glycation Index and Coronary Artery Inflammation in Type 2 Diabetes Mellitus Based on CCTA.
Hemoglobin glycation index (HGI) is used to quantify the biological variation of hemoglobin A1c (HbA1c). The present study explored the relationship between HGI and coronary artery inflammation in pat...
Atherosclerotic plaques preferentially form at the vascular bifurcations and inner curvature of the aortic arch, where oscillatory shear stress (OSS) induces endothelial cell (EC) inflammation, which ...
[Study of the Correlation Between MRI Parameters, Microvascular Density, and Prognosis in Glioma].
OBJECTIVE: To analyze the correlations between multimodal MRI examination parameters - apparent diffusion coefficient (ADC), cerebral blood flow (CBF), and choline (Cho)/creatine (Cr)-and microvessel ...
SAM68 is a multifunctional post-transcriptional regulator of cardiomyocyte differentiation.
RNA-binding proteins (RBPs) of the STAR family play key roles in mammalian development, yet their contributions to lineage specification remain incompletely understood. Here, using CRISPR-Cas9 knockou...