A Study on the Clinical Phenotypes and Genetic Analysis of ENG Variants in Four Hereditary Hemorrhagic Telangiectasia Type 1 Families.
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder primarily caused by pathogenic variants in the ENG gene, leading to clinical manifestations including...
Associations of Patient Morphology and Venous Anatomy with Early Changes in Upper-Extremity Venous Blood Flow Following PICC Placement in Patients with Cancer: A Prospective Cohort Study.
PURPOSE: Ultrasound evaluation of target vein diameter before peripherally inserted central catheter (PICC) placement is recommended to control the catheter-to-vein ratio, but early hemodynamic change...
Shared neuropathological features of mild traumatic brain injury and anesthesia.
Mild traumatic brain injuries are highly prevalent and can produce persistent sequelae, creating substantial personal and societal burdens. Recent evidence suggests that anesthesia administration for ...
The potential connection between inflammatory bowel disease and Alzheimer's disease: mechanistic insights and therapeutic implications.
Inflammatory bowel disease (IBD) and Alzheimer's disease (AD) are two chronic conditions previously considered pathologically unrelated. However, accumulating epidemiological evidence suggests that pa...
Association of the TyG index and inflammatory burden index with AMR-defined coronary microvascular dysfunction and 12-month MACE after STEMI.
BACKGROUND: Metabolic dysfunction and inflammation may jointly contribute to coronary microvascular injury and adverse outcomes after primary percutaneous coronary intervention (PPCI) for ST-segment e...
Aortic dissection as a disease of vascular wall homeostasis: integrating vasa vasorum-inflammation-metabolism axis for mechanistic insight and clinical translation.
Aortic dissection (AD) has traditionally been viewed as an acute structural failure initiated by an intimal tear. However, accumulating evidence suggests that this catastrophic event represents the en...
Barrier-Immune Gating Failure in Gut-Brain Neuroinflammation: A Working Hypothesis and Conceptual Framework.
In the past two decades, advances in microbiomics and neuroimmunology have reframed the concept of "central immune privilege." Rather than simply proving a gut-brain connection, the translational chal...
Experimental techniques to evaluate IA-MSCs-mediated alleviation of vasogenic edema following ischemic stroke.
Ischemic stroke induced cerebral edema is a devastating complication which leads to excessive swelling, increased intracranial pressure (ICP) and rapid neurological deterioration. The mortality rate o...
Impact of cavernous internal carotid artery tortuosity on technical and clinical outcomes in mechanical thrombectomy for acute ischemic stroke: a single-center retrospective study.
BACKGROUND AND PURPOSE: Cavernous internal carotid artery (ICA) tortuosity may hinder catheter navigation during mechanical thrombectomy (MT) for acute ischemic stroke (AIS). However, its impact on pr...
Astrocyte-blood-brain barrier crosstalk in cerebral small vessel disease: linking barrier dysfunction to neurovascular failure.
Cerebral small vessel disease (CSVD) is a heterogeneous group of disorders involving the cerebral microvasculature and is a major cause of stroke and vascular cognitive impairment. The role of blood-b...
Efficacy and safety of transarterial chemoembolization combined with donafenib and camrelizumab for hepatocellular carcinoma with portal vein tumor thrombus: a dual-center, retrospective propensity score-matched analysis.
AIM: To evaluate the efficacy and safety of transarterial chemoembolization combined with donafenib and camrelizumab (TACE+D+C) versus TACE plus donafenib (TACE+D) in the treatment of hepatocellular c...
Interaction between genistein and the endothelial activation and stress index in relation to estimated 10-year atherosclerotic cardiovascular disease risk classification.
BACKGROUND: The Endothelial Activation and Stress Index (EASIX) has been proposed as a marker of endothelial stress and may be associated with atherosclerotic cardiovascular disease (ASCVD) risk. Whet...
Targeted metabolomics of postmortem human cardiac tissue using the Biocrates MxP Quant 500 kit.
AIM: This proof-of-concept study aimed to evaluate the feasibility and analytical performance of the Biocrates MxP® Quant 500 kit, originally developed for biofluids, to postmortem human cardiac tissu...
The aberrant right subclavian artery and non-recurrent laryngeal nerve: a cadaveric study.
BACKGROUND: The aberrant right subclavian artery (ARSA), or arteria lusoria, is an aortic arch variant in which the right subclavian artery arises distal to the left subclavian artery and typically fo...
Effects of Acupuncture on Arterial Hypertension and Endothelial Dysfunction: The AHEaD Trial.
BACKGROUND: Sympathetic overactivity, oxidative stress, and impaired nitric oxide (NO)-mediated vasodilation are key mechanisms involved in the pathogenesis of hypertension. Acupuncture may decrease b...
[Thoracobifemoral bypass surgery with replacement of visceral arteries in a patient with nonspecific aortoarteritis].
The authors present a rare case of severe symptomatic involvement of multiple vessels in a young female patient with nonspecific aortoarteritis (Takayasu's disease). She underwent thoracobifemoral byp...
Thermomechanics analysis of cryopreservation by vitrification of the popliteal artery.
This study aims at exploring packaging configurations and thermal protocols to reduce thermomechanical stress during cryopreservation by vitrification of the popliteal artery and thereby reducing the ...
Gut Microbiota-Derived Butyrate Strengthens Blood-Brain Barrier Integrity and Attenuates Streptococcus suis SC19-Induced Meningitis: Involvement of the Gut-Brain Axis.
Streptococcus suis serotype 2 (SS2) is a major zoonotic pathogen that causes severe meningitis and high mortality in both humans and swine. Growing evidence shows that metabolites generated along the ...
Spatiotemporal Dynamics and Cellular States of Neuroinflammation in Amyotrophic Lateral Sclerosis: Implications for Stage‑Specific Therapeutics.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex and heterogeneous pathogenesis. Accumulating preclinical and clinical evidence indicates that neuroinflammation is an ...
Precision Drug Delivery Strategies for Treatment-Resistant Depression: Opportunities and Challenges of FUS-BBBO and Spatial Molecular Profiling.
In this review, treatment-resistant depression (TRD),a clinically defined subtype of major depressive disorder, is characterized by substantial disease burden and heterogeneous pathophysiology, with m...