Methodological development of a pneumatic artificial muscle-driven left ventricular simulator using interpretive structural modeling.

Mock circulation systems can replicate a wide range of cardiac operating scenarios, such as cardiovascular diseases, particularly muscular dysfunctions. These systems are operated by sophisticated con...

Anatomical assessment of the relationship between the aortic bifurcation and the vertebral body in individuals with normal vertebral column structure using computed tomography angiography.

BACKGROUND: Anterior approaches to the lumbar spine, particularly anterior lumbar interbody fusion (ALIF) at L4-L5 and L5-S1, are increasingly common. Vascular injury involving the aortic bifurcation ...

Temporal Trends and In-hospital Outcomes of Transcatheter Aortic Valve Implantation in Bicuspid Aortic Valves in Brazil: A Propensity-Matched Analysis.

BACKGROUND: Bicuspid aortic valve (BAV) is a significant risk factor for aortic stenosis (AS). Yet, the outcomes of transcatheter aortic valve implantation (TAVI) remain unclear, as most randomized tr...

CAPoxy: A feasibility study to investigate multispectral imaging in nailfold capillaroscopy.

BACKGROUND: Nailfold capillaroscopy enables visualisation of structural abnormalities in the microvasculature of patients with systemic sclerosis (SSc). The objective of this feasibility study was to ...

Deep learning in Myocarditis: A novel approach to severity assessment.

BACKGROUND: Myocarditis is life-threatening in the acute phase, yet biopsy-the diagnostic gold standard-lacks an objective method to quantify cardiomyocyte damage. We developed deep learning models to...

Survival outcomes of intensity-modulated radiotherapy combined with immunotherapy and targeted therapy for hepatocellular carcinoma with classification I-IV portal vein tumor thrombus: a propensity score matching study.

PURPOSE: The study aimed to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) combined with immunotherapy and targeted therapy (IT) in hepatocellular carcinoma (HCC) patients...

Exploring the Role of Nesprin1 in isoproterenol-induced heart failure: Insights into pathogenesis and therapeutic implications.

OBJECTIVE: This study aimed to investigate the role of Nesprin-1 in the development and progression of isoproterenol (ISO)-induced heart failure (HF) and to elucidate the underlying molecular mechanis...

Middle Meningeal Artery Embolization (MMAE) Versus Surgical Evacuation for Recurrent and Refractory Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis.

BACKGROUND: Recurrent and refractory chronic subdural hematoma (cSDH) remains a significant neurosurgical challenge due to high recurrence rates and morbidity associated with repeated surgical interve...

Characterization of virus neuroinvasion, blood-brain barrier integrity and neuroinflammation following Powassan virus infection in mice.

Powassan virus (POWV) is a tick-borne Orthoflavivirus transmitted by Ixodes tick species. POWV causes fatal encephalitis in approximately 10-30% of neurological cases, and long-lasting neurological se...

Impact of breastfeeding and Mycoplasma pneumoniae co-infection on coronary artery lesions in Kawasaki disease: a retrospective cohort study.

OBJECTIVE: This study aims to investigate the impact of different feeding patterns and Mycoplasma pneumoniae (MP) infection on coronary artery lesions (CAL) in children with Kawasaki disease (KD), par...

Mitochondrial respiration and nucleotide profiling in human left internal mammary artery from CABG: a novel real-time ex vivo approach.

Mitochondrial dysfunction plays a critical role in the pathogenesis of cardiovascular and metabolic diseases. However, direct assessment of mitochondrial respiration in human vascular tissue remains t...

[Subdural hematoma without subarachnoid hemorrhage caused by ruptured traumatic distal aneurysm of anterior cerebral artery].

OBJECTIVE: To describe a rare complication of non-penetrating traumatic brain injury. MATERIAL AND METHODS: We present a 16-year-old patient with multiple skeletal lesions and mild traumatic brain inj...

Heart failure and its progression is associated with changed lymphocyte profile in epicardial adipose tissue.

INTRODUCTION: Chronic inflammation is increasingly recognized as a key contributor to the development and progression of heart failure (HF), with epicardial adipose tissue (EAT) emerging as an importa...

Preoperative inferior vena cava ultrasound for volume optimization in resection of functioning pheochromocytoma and paraganglioma: association with perioperative adverse outcomes in a prospective observational cohort.

BACKGROUND: Optimizing intravascular volume (IV) before surgery is crucial for patients undergoing resection of functioning pheochromocytomas and paragangliomas (PPGLs). While point-of-care ultrasound...

Normal Reference Values for Cardiovascular Magnetic Resonance: An Analytical-Comparative Review with Emphasis on the Brazilian Population.

BACKGROUND: Cardiovascular magnetic resonance (CMR) is the reference standard for morphofunctional cardiac assessment. In Brazil, the application of international normal reference values faces challen...

Evaluation of early retinal microvasculature changes after cardiopulmonary bypass.

PURPOSE: This study aimed to evaluate early postoperative changes in retinal microvasculature in patients undergoing cardiopulmonary bypass surgery by comparing preoperative and postoperative measurem...

CCR2 deficiency protects against doxorubicin-induced cardiac dysfunction through enhanced IL12B-dependent autophagy.

RATIONALE: Doxorubicin (DOX) is a potent chemotherapeutic agent whose antitumor benefits are limited by a well-recognized, dose-dependent cardiotoxicity. While previous studies have implicated inflamm...

Neural-immune-cardiovascular axis: from mechanistic crosstalk to therapeutic targets in cardiovascular disease.

The neural-immune-cardiovascular axis represents an emerging and highly integrated physiological and pathophysiological concept, describing a complex bidirectional communication network between the ne...

[The effect of acute heat injury on the morphological features of the cardio-pulmonary system].

Acute heat injury is one of the main triggers among exogenous factors affecting human vital functions and survival, especially in a changing climate. Despite this, the processes occurring in the human...

Evaluating cord blood S100B protein concentration as a potential biomarker associated with fetal hypoxia in late fetal growth restriction: A prospective cohort study protocol.

INTRODUCTION: S100B protein is a biomarker associated with central nervous system (CNS) injury following hypoxic-ischemic events. Measurement of S100B levels in umbilical cord blood may provide a noni...