Sequential tislelizumab plus bronchial arterial chemoembolization and systemic chemotherapy in advanced NSCLC with bulky tumors: efficacy and safety.

BACKGROUND: Bulky tumor (T ≥ 50 mm) significantly compromises treatment outcomes in advanced non-small cell lung cancer (NSCLC) due to excessive tumor burden. Bronchial arterial chemoembolization (BAC...

Targeting neuroimmune interactions: the therapeutic potential of kaempferol in immune-related central nervous system disorders.

Neuroinflammation is recognized as a pivotal pathological process underlying a spectrum of neurological disorders. The exploration of natural flavonoids as therapeutic agents has substantially advance...

Diabetic Atrial Cardiomyopathy: Pathogenesis, Diagnosis, Management, AI-Driven Diagnosis, and Risk Prediction.

BACKGROUND: Diabetic atrial cardiomyopathy, a component of diabetic cardiomyopathy, is increasingly recognized. However, atrial-focused mechanistic and clinical frameworks remain less developed than v...

Surgical management of refractory massive hemoptysis from pulmonary artery pseudoaneurysm due to Streptococcus constellatus: a rare case report and literature review.

Pulmonary artery pseudoaneurysm (PAP) is a rare but potentially fatal vascular lesion resulting from focal disruption of the pulmonary arterial wall. Although hemoptysis from the pulmonary arterial sy...

Intranasal Biodegradable Nanomedicine for Epilepsy Management: Targeting the Brain Beyond the Blood-Brain Barrier.

Epilepsy is a common chronic neurological disorder characterized by recurrent, unprovoked seizures arising from abnormal neuronal hyperexcitability and hypersynchronous electrical activity within the ...

Biocompatibility Assessment of a Hybrid Material Based on Epoxy-Treated Pericardium and Polyvinyl Alcohol Cryogel in a Rat Vascular and Subcutaneous Implantation Model.

UNLABELLED: The aim of the study was to evaluate the biocompatibility of a hybrid material based on epoxy-treated bovine pericardium and cryostructured polyvinyl alcohol (PVA) after implantation into ...

Migration of Cardiac Cells: Hot Topics that have not Attracted Clinical Attention.

Cell migration plays a critical role in various physiological and pathological processes, particularly in the development and repair of cardiac diseases. It is a complex, multi-step process involving ...

Treatment with Capsinoids Promotes Impaired Cardiomyocyte Contractility in Obesity without Positively Modulating Metabolic Parameters.

BACKGROUND: Capsinoids (Cap) are bioactive compounds with thermogenic properties capable of promoting physiological changes and aiding digestion, potentially influencing fat loss in obesity. However, ...

Robotic kidney autotransplantation with extracorporeal arterial and venous reconstruction for complex ureteral stricture: a technical note.

INTRODUCTION: Kidney autotransplantation is an organ-preserving option for selected patients with complex ureteral or renovascular pathology not amenable to in situ reconstruction. Conventional open a...

[Total arterial myocardial revascularization in elderly and senile patients.].

This review analyzes the efficacy and safety of total arterial revascularization (TAR) in elderly patients. Given the global demographic aging and the high prevalence of coronary artery disease in ind...

[Myocardial contractility and morphological changes in vital organs in 24-month-old rats with isoproterenol-induced chronic heart failure.].

Aim - an appropriate experimental model is required to investigate the development of chronic heart failure in the elderly and to evaluate pharmacological interventions. Models based on aged animals r...

[Aortic valve defects as a risk factor for delelopment and complications of coronary artery disease in the elderly.].

The presence of aortic valve defects in patients is associated with a more severe course of coronary heart disease and heart failure. This article examines the impact of aortic valve defects on the ri...

Protein Lactylation in Central Nervous System Diseases: Molecular Mechanisms and Targeted Therapeutic Strategies.

Lactate, once considered merely a metabolic byproduct, is now recognized as a cornerstone of central nervous system (CNS) homeostasis, serving as both a vital energy substrate and signaling molecule. ...

Pathophysiological mechanisms and therapeutic potential of E-selectin in pulmonary arterial hypertension.

Pulmonary arterial hypertension (PAH) is a life-threatening pulmonary vascular disease characterized by progressive obstructive remodeling of the small pulmonary arteries. Its pathophysiological core ...

Severe Trileaflet Aortic Stenosis Without Significant Valve Calcification in an Older Adult.

Severe aortic stenosis (AS) is most often caused by progressive valve calcification; however, rare cases occur with little or no calcification. We report a 79-year-old man with a trileaflet aortic val...

Surgical Reconstruction of a Suprahepatic Inferior Vena Cava Aneurysm Using a Tubularized Bovine Pericardial Patch.

Inferior vena cava (IVC) aneurysms are rare clinical entities with fewer than 80 cases reported in the literature. Type I aneurysms involving the suprahepatic IVC present significant surgical challeng...

Niacin alleviates cerebral microvascular endothelial cell apoptosis induced by hypervirulent Klebsiella Pneumoniae by reducing the accumulation of reactive oxygen species.

INTRODUCTION: Hypervirulent Klebsiella pneumoniae (hvKp) is an important pathogen causing central nervous system infections, including meningitis; however, the mechanisms by which it disrupts the bloo...

Clinical outcomes of injectable and conventional pulmonary valve replacement in severe pulmonary regurgitation.

BACKGROUND/AIM: Pulmonary regurgitation following tetralogy of Fallot repair is a common long-term complication requiring pulmonary valve replacement. Injectable bioprosthetic valves offer a less inva...

Common femoral vein wall thickness as a supportive imaging marker in the differential diagnosis of Behçet's uveitis.

BACKGROUND/AIM: Ocular involvement is a major cause of morbidity in Behçet's disease (BD), and its diagnosis may be challenging, particularly for patients with isolated ocular manifestations or incomp...

Long noncoding RNA Gpr137b-ps mediates 15-PGDH-induced angiogenesis in brain microvasculature following tMCAO in mice.

BACKGROUND: Angiogenesis is essential for recovery following ischemic stroke, as brain microvascular endothelial cells (BMVECs) drive vascular repair. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) i...