Glymphatic dysfunction in cerebellar neurodegeneration: mechanistic insights and emerging clinical implications.
BACKGROUND AND PURPOSE: The glymphatic system is a glial-dependent perivascular clearance pathway that maintains central nervous system homeostasis through cerebrospinal fluid and interstitial fluid e...
Perforation of the right ventricle and inferior vena cava by bone cement after percutaneous vertebroplasty: A case report.
RATIONALE: Percutaneous vertebroplasty (PVP) is widely used to treat vertebral compression fractures. Although it is generally considered a minimally invasive procedure, leakage and systemic migration...
Rare circle of Willis variants associated with multiple intracranial aneurysms and subarachnoid hemorrhage: A case report.
RATIONALE: Subarachnoid hemorrhage from a ruptured intracranial aneurysm is a type of stroke with high rates of mortality and disability, and the prevalence of aneurysm formation increases in the pres...
Aggressive Sporadic Renal Angiomyolipoma With Tumor Thrombus Extending Into the Inferior Vena Cava, Right Atrium, and Right Ventricle: A Multidisciplinary Case Report.
BACKGROUND Renal angiomyolipoma (AML) is a typically benign mesenchymal tumor with an indolent clinical course. Rarely, AML demonstrate aggressive vascular invasion, most commonly in association with ...
Differential Effects of Cannabidiol and Cannabigerol on Cognition, Neuroinflammation, and Blood-Brain Barrier Integrity in a Rat Model of Iron Overload.
Iron is an essential micronutrient for brain development, participating in mitochondrial respiration, myelination, and neurotransmitter synthesis. However, previous studies have demonstrated that exce...
The interplay between chronobiology, neuroinflammation, and the glymphatic system in neurodegenerative diseases.
Neurodegenerative diseases are traditionally characterized by the progressive accumulation of misfolded proteins and chronic neuroinflammation. However, emerging evidence indicates that the pathogenes...
Three-dimensional tracheal morphologic changes after left pulmonary artery sling repair with and without tracheoplasty.
PURPOSE: In patients with a left pulmonary artery sling (LPAS) and congenital tracheal stenosis, indications for simultaneous slide tracheoplasty remain controversial. This study quantified three-dime...
Endoscopic endonasal transcavernous surgery for knosp grade 3-4 growth hormone-secreting pituitary neuroendocrine tumors: surgical outcomes and predictors of biochemical remission.
Achieving biochemical remission in growth hormone-secreting pituitary neuroendocrine tumors (GH-PitNETs) with cavernous sinus invasion (Knosp grade 3-4) remains a significant surgical challenge. The o...
Genetics-Informed Mapping Identifies a CRIM1-Associated Endocardial Inflammatory Remodeling State in Acute Myocardial Infarction.
BACKGROUND Acute myocardial infarction (AMI) reflects inherited susceptibility and inflammatory remodeling, but the cellular contexts linking genetic risk to disease remain unclear. MATERIAL AND METHO...
Multiterritorial tailored revascularization in adult Moyamoya patients: expanding revascularization approaches to ACA and PCA territories.
Extracranial-intracranial (EC-IC) bypass surgery within the middle cerebral artery (MCA) territory is the gold standard for treating Moyamoya patients once hemodynamic insufficiency is confirmed. Alth...
Bridging the Gap: Harnessing Phytochemical-Loaded Nanocarriers for Enhanced Epilepsy Treatment.
Epilepsy is a chronic neurological disorder characterized by recurrent seizures, posing a significant global public health burden. While conventional anti-seizure medications remain the primary therap...
Cardiac tertiary immune niches drive immune activation in immune checkpoint inhibitor myocarditis.
Immune checkpoint inhibitor (ICI) myocarditis is a rare but frequently fatal immune-related adverse event of cancer immunotherapy. Understanding the mechanisms of this toxicity is critical to balancin...
Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart.
The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear....
The structure of the native cardiac crossbridge in the rigor state.
Cardiac contraction is driven by double-headed myosin cycling on cardiac thin filaments, where troponin-tropomyosin regulates myosin access to actin. Prior high-resolution structural studies used a si...
A Validated, explainable machine learning-based preoperative risk model for microvascular invasion in hepatocellular carcinoma.
PURPOSE: This investigation aimed to develop and validate a diagnostic algorithm for preoperatively assessing the likelihood of microvascular invasion (MVI) in patients with hepatocellular carcinoma (...
SGLT2 inhibitors activate pantothenate kinase in the human heart.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate pantothen...
tRNA-derived small RNAs in vascular smooth muscle cell phenotypic switching and vascular remodelling.
tRNA-derived small RNAs (tsRNAs) are noncoding RNAs generated from precursor or mature tRNAs. Basal tsRNA levels are detectable under physiological conditions, but their production increases sharply u...
Short-term retinal microvascular and structural changes after epi-on and epi-off corneal cross-linking assessed by SD-OCTA.
PURPOSE: To evaluate and compare short-term retinal microvascular and structural changes following ultraviolet-A (UVA) exposure in corneal cross-linking (CXL) procedures with and without epithelial re...
Severe multivessel coronary artery spasm presenting as very high-risk acute coronary syndrome.
Coronary artery spasm is an important cause of myocardial ischaemia and acute coronary syndrome in the absence of obstructive coronary artery disease. Simultaneous multivessel epicardial coronary arte...
Exercise and Endothelial Function: Insights from a Redox Perspective.
PURPOSE OF REVIEW: This review aims to synthesize the evidence linking exercise, redox regulation, and endothelial function. It considers the effects of different modes of regular exercise, acute exer...