Changes in retinal venous diameter in proliferative diabetic retinopathy patients with diabetic macular edema following faricimab treatment: an observational study.
INTRODUCTION: To evaluate the effect of intravitreal faricimab injections on retinal venous diameter in proliferative diabetic retinopathy (PDR) patients with diabetic macular edema (DME). METHODS: Th...
Uncommon course of the common palmar digital artery of the fourth web space beneath the deep transverse metacarpal ligament: a cadaveric case report.
BACKGROUND: Anatomical variations of the palmar digital arteries are reported less frequently than variations of the superficial and deep palmar arches, particularly regarding their precise topographi...
Associations between echocardiographic parameters and aerobic performance in young athletes.
BACKGROUND AND OBJECTIVES: Cardiac morphology can be shaped according to chronic and acute exercise and provides important findings regarding cardiac response to different types of performance. Howeve...
Single-cell and spatial multi-omics reveal estrogen-mediated vaginal wall microenvironment remodeling and a perivascular reparative niche in postmenopausal pelvic organ prolapse.
INTRODUCTION: Local estrogen is widely used to improve vaginal mucosal status and relieve menopausal urogenital symptoms in patients with pelvic organ prolapse (POP), yet clinical outcomes are inconsi...
Progesterone signaling in cardio-renal physiology and pathophysiology.
Progesterone is a multifunctional steroid hormone essential for reproductive function, yet its roles in cardiovascular and renal physiology remain comparatively less understood than those of estrogen....
Radial pulse harmonic analysis for cardiometabolic assessment: a computational and translational mini review.
PURPOSE: Radial pulse harmonic analysis has emerged as a quantitative frequency-domain approach for non-invasive assessment of cardiovascular and metabolic physiology through characterization of arter...
Contractile effects of albiglutide in the human and mouse atrium.
Albiglutide was developed as a glucagon-like-peptide 1 receptor (GLP-1R) agonist for the treatment of type 2 diabetes. We tested the hypothesis that albiglutide exerts a positive inotropic effect in t...
Platelet membrane biomimetic nanoparticle-based targeted delivery system of simvastatin for the treatment of ischemic stroke.
Blood-brain barrier (BBB) disruption and excessive neuroinflammation are pivotal drivers of cerebral ischemia-reperfusion injury. Although simvastatin (SV) possesses potent pleiotropic effects in prom...
Myocardial microvascular patterns in histological sections from patients with and without type 2 diabetes.
Type 2 diabetes is associated with small vessels dysfunction. This study assessed whether type 2 diabetes is associated with changes in the myocardial capillary pattern in two-dimensional histological...
Yangxin Tongluo Decoction Protects Against Sepsis-Associated Cardiac Dysfunction Through Regulating Nrf2 Pathway.
BACKGROUND: Sepsis-induced cardiac dysfunction is a major cause of high mortality in critically ill patients. Yangxin Tongluo decoction (YXTLD), a traditional Chinese medicine (TCM) formula, is clinic...
Clinical and preclinical evidence of meningeal immunity and glymphatic pathways in stroke: a systematic review.
UNLABELLED: Glymphatic transport, meningeal lymphatic drainage, and meningeal immunity have been implicated in metabolic waste clearance, cerebral edema formation, and the regulation of neuroinflammat...
Characterization of aortic endothelial dysfunction in ovariectomized allergic asthmatic mice.
Clinical observations suggest that sex hormones may have a role in female asthma-related cardiovascular diseases (CVD), however, the mechanism by which sex hormones may influence CVD in asthmatics is ...
Habitual Oily Fish Intake and Microvascular Integrity in Frequent Fish Consumers: A Population-Based, Cross-Sectional Pilot Study.
ObjectivesMicrovascular health is increasingly recognized as a determinant of functional aging and cardiometabolic risk in aging populations. Marine omega-3 polyunsaturated fatty acids (ω-3 PUFAs), pr...
Vasorelaxant effect of Tribulus terrestris extract and fractions on isolated rat aortae.
Tribulus terrestris (Zygophylaceae) has been used by traditional medicine as tonic, aphrodisiac and diuretic agent, as well as to treat cardiovascular diseases. However, the vascular effect of Tribulu...
Anatomical variability of the superior thyroid artery: a computed tomography-based study in a Polish population and a comprehensive meta-analysis.
BACKGROUND: The superior thyroid artery (STA) shows considerable anatomical variability with important implications for thyroid and laryngeal surgery. Although the external carotid artery (ECA) is the...
Lipidomic Profiling and Biological Aging in Patients with Coronary Microvascular Dysfunction.
BACKGROUND: Coronary microvascular dysfunction (CMD) was frequently encountered in patients with angina in the absence of epicardial coronary stenosis. CMD was associated with adverse outcomes while t...
Overt hyperthyroidism is associated with increased dispersion of ventricular repolarization: a case-control study.
BACKGROUND: Overt hyperthyroidism is associated with increased cardiovascular morbidity, including tachyarrhythmias and heart failure. Although standard electrocardiographic abnormalities are well rec...
Recent research progress and future directions of intracerebral hemorrhage.
Up to now, Intracerebral hemorrhage (ICH) remains a type of cerebrovascular emergency with high incidence, mortality and disability rates. The secondary brain injury following ICH involves a series of...
MitoQ Ameliorates Diabetic Cardiomyopathy by Inhibiting the mtROS-TXNIP-NLRP3 Pathway.
PURPOSE: To determine whether mitoquinone mesylate (MitoQ) could treat diabetic cardiomyopathy (DCM) by inhibiting the mitochondrial reactive oxygen species (mtROS)/thioredoxin (TRX)-interacting prote...
Lymphocytic Myocarditis - A New Histopathological Definition and Classification for Endomyocardial Biopsies, Surgical and Autopsy Specimens ("Seaport Criteria").
Lymphocytic myocarditis is the most common form of inflammatory myocardial disease. However, its histopathological diagnosis has been burdened by considerable subjectivity until recently. In 2025, the...