DOACs vs Warfarin for Post-myocardial Infarction Left Ventricular Thrombus: A GRADE-assessed Meta-Analysis With Trial Sequential Analysis of Randomized Trials.
Background and PurposeCurrent AHA and ACC guidelines warrant studies comparing direct oral anticoagulant (DOAC) and warfarin for post-myocardial infarction (MI) left ventricular thrombus (LVT). DOAC i...
Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis.
IMPORTANCE: Sensorineural hearing loss (SNHL) accompanied by vertigo is a condition with clinical heterogeneity. Understanding vascular underpinnings is crucial for management. OBJECTIVE: To investiga...
The associations between nailfold microvascular abnormalities and systemic inflammation or Th17/Treg dysregulation in rheumatoid arthritis.
OBJECTIVES: To investigate the abnormal characteristics of nailfold microcirculation (NMC) in patients with rheumatoid arthritis (RA) and to further analyze the associations between these abnormalitie...
Effect of RAS inhibitors on retinal microvasculature in DKD using AI-based ultra-wide-field images.
BACKGROUND: Diabetic kidney disease (DKD) and diabetic retinopathy (DR) represent two major microvascular complications of diabetes mellitus (DM). Previous studies have suggested that renin-angiotensi...
The liver-brain axis, from its function to preventive therapeutic strategies in diseases.
The liver-brain axis (LBA) represents a bidirectional communication network between the liver and the central nervous system (CNS), governed by integrated neural, humoral, and immune signaling pathway...
Endothelial TGFβ signaling modulates choroidal neovascularization severity via myeloid-endothelial cell interaction.
INTRODUCTION: The blood-retinal barrier (BRB) is essential for maintaining retinal homeostasis, consequently its disruption contributes to pathological angiogenesis in diseases such as neovascular age...
Beyond AQP-4: convergent glymphatic-meningeal lymphatic dysfunction underlying multifactorial migraine pathogenesis.
The glymphatic system (GS) functions as a critical pathway for waste clearance from the brain, facilitating soluble protein and metabolite drainage. Recently, GS dysfunction has emerged as a potential...
Triple Antithrombotic Therapy vs Dual Antiplatelet for Prevention of Left Ventricular Thrombus After Anterior Myocardial Infarction: An Updated Meta-Analysis.
PurposeTo evaluate the efficacy and safety of triple antithrombotic therapy (TT) versus dual antiplatelet therapy (DAPT) for prevention of left ventricular thrombus (LVT) following anterior myocardial...
Meteorin-like controls metabolic adaptations and physiological myocardial remodeling in pregnancy and lactation.
INTRODUCTION: The gestation-lactation period involves profound but reversible cardiac remodeling. Meteorin-like (Metrnl) has emerged as a regulator of cardiac metabolism in pathological settings, but ...
Case report: Pediatric vascular Behçet's disease with prominent arterial involvement: a case series of five patients.
BACKGROUND: Vascular Behçet's disease (VBD) rare and severe subtype of Behçet disease characterized by vascular inflammation. Its prevalence in the pediatric population is extremely low. This case ser...
MicroRNA-383-5p regulation of NADPH oxidase 4 alleviates hemorrhagic transformation and improves acute outcomes after endovascular recanalization in acute ischemic stroke.
BACKGROUND: Hemorrhagic transformation (HT) following reperfusion therapy is associated with poor outcomes in patients with acute ischemic stroke. Here, we determined the role of microRNA-383-5p (miR-...
Transport Across the Blood-Brain Barrier.
The blood-brain barrier (BBB) is a dynamic barrier essential for maintaining the microenvironment of the brain. Although the special anatomical features of the BBB determine its protective role for th...
Modeling of Tumor Cell Adhesion, Extravasation, and Sorting in a Microvascular System.
Blood flow dynamics in microvessels dictate the transport modes of circulating tumor cells (CTCs) and, consequently, influence their metastatic potential. While extensive biochemical and biological st...
Tumor Metastasis in the Microcirculation.
Tumor cell metastasis through blood circulation is a complex process and is one of the great challenges in cancer research as metastatic spread is responsible for ∼90% of cancer-related mortality. Tum...
The Examination of Arterial Function and Mechanotransduction Through Brachial Arteries via Flow-Mediated Dilation.
Cardiovascular disease remains one of the leading causes of mortality worldwide, with endothelial dysfunction playing a pivotal role in its initiation and progression. Early detection and accurate eva...
Abdominal Aortic Aneurysm Pathomechanics, Current Understanding and Emerging Directions: A Perspective for 2025 and Beyond.
Abdominal aortic aneurysms (AAAs) are permanent, local expansions of the abdominal segment of the aorta that can potentially be fatal if progressing to rupture. AAAs are rarely found in patients under...
A Brief Overview of Biomechanics and Mechanobiology of the Pulmonary Circulation.
This chapter delves into the biomechanics and mechanobiology of the right side of the human circulatory system, focusing on the vascular pulmonary circulation driven by the right ventricle. Pulmonary ...
Endothelial Nuclear and Cytoskeletal Responses to Mechanical Stresses.
The ability of vascular endothelium to sense and respond to the mechanical stimuli generated by blood flow is pivotal in maintaining arterial homeostasis. A steady laminar flow tends to provide athero...
Vascular Mechanobiology: From Membrane to Nucleus.
The vascular wall is continuously exposed to complex hemodynamic forces in vivo due to blood flow. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) experience distinct mechanical stres...
Glycosaminoglycans and Their Role in Capillary Walls.
Glycosaminoglycans (GAGs) are polysaccharide chains that extend into the vascular lumen and are embedded throughout the capillary wall. They have a multitude of biophysical and biochemical roles inclu...