Doppler Evaluation of Foetal Pulmonary Artery in Intrahepatic Cholestasis of Pregnancy: A Prospective Study.

BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent liver disease specific to pregnancy, with higher incidence of adverse pregnancy outcomes. Keeping this in mind, this study...

[Caseous mitral annulus calcification: a case report].

Caseous calcification of the mitral annulus is a rare entity, often unrecognised by clinicians and radiologists alike. It can be difficult to diagnose on echocardiography, with the risk of confusion w...

Exercise-conditioned extracellular vesicles in Alzheimer's disease: a multi-organ signaling network linking peripheral adaptation to brain pathology.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder in which amyloid-β accumulation, tau pathology, chronic neuroinflammation, cerebrovascular impairment, and synaptic dysfunction ...

Potential Diagnostic and Therapeutic Uses of DPT in Acute Type A Aortic Dissection.

PURPOSE: Acute Type A aortic dissection (ATAAD) is a catastrophic cardiovascular emergency with high mortality and few treatment options. Diagnostic biomarkers or targeted treatments remain in the rud...

Electrophysiological Modeling and Molecular Dynamics Simulations of Cardiac Sodium Channels in Brugada Syndrome.

Brugada syndrome (BrS) is a rare but potentially fatal genetic cardiac disorder, primarily caused by mutations in sodium and potassium ion channels, leading to ventricular arrhythmias and sudden cardi...

Double-staged thromboembolectomy in acute visceral ischemia with atypical origin of right hepatic artery, complicated by secondary intestinal infiltrate.

INTRODUCTION: Acute mesenteric ischemia is a rare but serious vascular complication often accompanied by intestinal damage. Treatment typically involves surgical and endovascular procedures. Proper di...

Rapidly progressive popliteal artery aneurysm with fistula into the venous system as a rare complication of infective endocarditis.

INTRODUCTION: Infective endocarditis (IE) is a serious disease with a high mortality rate. Complications of IE are frequent and serious, most of them manifesting as various forms of ischemia. Its rare...

Vancomycin-impregnated decellularized bovine pericardium membranes coating silicone implants: in-vivo biocompatibility and antibacterial efficacy in a rat model.

PURPOSE: To evaluate the inflammatory response, fibrotic encapsulation, tissue integration, and antibacterial effectiveness of silicone implants coated with decellularized bovine pericardium membranes...

Repair of Membranous Tracheal Defect Using Sutureless Free Pericardial Fat Pad Covering During Endoscopic Resection of Tracheal Mucus Retention Cyst: A Case Report.

A man in his 60s was referred to our hospital for evaluation of a cystic nodule on the membranous trachea detected on computed tomography. Bronchoscopy revealed a submucosal nodule. After dissecting t...

Topographic anatomy and anatomic morphometry of abdominal aorta and renal artery versus atherosclerotic plaque formation: apples and pears?

OBJECTIVE: The aim of this retrospective study was to evaluate the relationship between renal artery morphometry and renal artery plaque formation and location using multislice computed tomography ang...

When Anatomy Meets Pathology: May-Thurner Syndrome as an Underdiagnosed Cause of Acute DVT.

May-Thurner Syndrome (MTS) is an underrecognized anatomic cause of left-sided deep vein thrombosis (DVT) resulting from compression of the left common iliac vein by the overlying right common iliac ar...

Automated segmentation of pituitary adenomas, pituitary gland, and internal carotid arteries on routine coronal contrast-enhanced T1-weighted MRI: a single-sequence feasibility study.

INTRODUCTION: Pituitary adenomas (PAs) alter the anatomy of the pituitary gland (PG) and internal carotid arteries (ICAs), requiring accurate segmentation for surgical planning and risk assessment. Mu...

Association of the Endothelial Activation and Stress Index with Mortality in Critically Ill Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.

BACKGROUND: In view of the established role of endothelial dysfunction in the pathophysiology of chronic obstructive pulmonary disease (COPD), the Endothelial Activation and Stress Index (EASIX), a va...

A human 3D BBB chip model of acute stroke simulating a reversible penumbra.

Ischemic stroke is a leading cause of mortality and disability worldwide. However, existing models often fail to replicate key aspects of human pathophysiology, particularly blood-brain barrier (BBB) ...

Perfusion imaging findings, and outcomes between computed tomography perfusion selected basilar artery occlusion and anterior circulation stroke patients undergoing endovascular treatment.

BACKGROUND: Basilar artery occlusion (BAO) is a severe form of ischemic stroke associated with high morbidity and mortality. Whether BAO patients derive similar benefits from CT perfusion (CTP)-guided...

Resting energy expenditure under fasting conditions is primarily explained by fat-free mass rather than cardiac autonomic markers.

BACKGROUND: Resting Energy Expenditure (REE) represents the largest component of total daily energy expenditure. While fat-free mass (FFM) is its primary predictor, substantial interindividual variabi...

Targeted Delivery of Schisandrin A to Cardiac Endothelium Alleviates Myocardial Ischemia-Reperfusion Injury via Suppression of Ferroptosis.

PURPOSE: Myocardial microvascular injury plays a critical role in myocardial ischemia‑reperfusion injury (MI/RI), and ferroptosis has emerged as an important contributor to cardiac damage. Although Sc...

BIRC3-CASP8 axis orchestrates the PANoptosis spectrum: taming the inflammatory storm to prevent post-ischemic heart failure.

BACKGROUND: The progression of heart failure (HF) following myocardial ischemia/reperfusion (I/R) injury is driven by regulated cell death. Unlike the restrained nature of apoptosis, pyroptosis and ne...

Crosstalk in Alzheimer's-delirium nexus: Molecular mechanisms and therapeutic repurposing.

Alzheimer's disease (AD) and delirium, though distinct in clinical tempo, converge mechanistically at the intersection of neurovascular dysfunction, glial activation, and metabolic collapse. This chap...

Pulmonary artery involvement in Behçet's disease patients: real-life data on aneurysm and thrombosis.

BACKGROUND: Pulmonary vascular involvement represents one of the most severe manifestations of Behçet's disease. Pulmonary artery aneurysm (PAA) and pulmonary artery thrombosis (PAT) are rare but pote...