The Molecular Structure of the Endothelial Glycocalyx. Models to Interpret High-Resolution Imaging of an Ordered Structure for the Molecular Filter at the Microvascular Wall.

The endothelial glycocalyx is a complex fibrous network of molecules that extends from the endothelial cell membrane for distances that range from less than 0.3 micron to several microns. The mechanis...

Endothelial Surface Glycocalyx in Vascular Functions and Diseases.

Endothelial cells (ECs), which form the inner lining of the vasculature, are perpetually exposed to mechanical stimuli from blood flow. Their capacity to sense and respond to these forces is essential...

Atypical eclampsia without severe hypertension - the role of ophthalmic artery Doppler and sFlt-1/PlGF ratio: a case report.

Eclampsia remains one of the most severe obstetric emergencies associated with substantial maternal and perinatal morbidity and mortality. Although classically regarded as a hypertensive complication ...

Propofol and Salvianolic Acid a Synergistically Attenuate LPS-Induced Myocardial Pyroptosis in Diabetic Mice via the SIRT1/HMGB1 Pathway.

BACKGROUND: We investigated whether propofol (PPF) combined with salvianolic acid A (SAA) confers synergistic cardioprotection in diabetic sepsis. METHODS: Diabetic-septic mice and high-glucose/LPS-tr...

Cardiac myocyte contractility, calcium dynamics, and morphology in Zucker diabetic fatty female and male rats - lacking data in this model of obesity and diabetes: A review.

Diabetes mellitus (DM) represents an increasing global health burden with type 2 diabetes mellitus (T2DM) accounting for most cases. T2DM is associated with microvascular and macrovascular complicatio...

Mechanistic constraints in dengue severity: a systematic review with evidence stratification and agent-based evaluation of logical sufficiency.

BACKGROUND: Severe dengue is a vascular immunopathology characterized by plasma leakage, thrombocytopenia, hemorrhage, and, in its most critical form, dengue shock syndrome. Although NS1-mediated endo...

Circadian control of immune homeostasis in cardiovascular health and disease.

The circadian system is an important regulator of cardiovascular immune homeostasis. Emerging evidence suggests that daily timing of immune responses may influence cardiovascular disease progression b...

Bidirectional communication between spinal cord injury and gut microbiota, from the bench to the bedside.

Spinal cord injury (SCI) is a type of central nervous system damage that often results in motor, sensory, and autonomic dysfunction, and can lead to death, with currently no effective treatment availa...

Primary Tricuspid Regurgitation in ACHD: Diagnosis and Treatment.

Primary tricuspid valve regurgitation includes congenital and acquired disorders, especially Ebstein anomaly and tricuspid valve dysplasia. Severe tricuspid regurgitation causes progressive right atri...

Single Ventricle Fontan: The Basics for General Cardiologists.

Single-ventricle physiology encompasses a heterogeneous spectrum of congenital cardiac malformations in which a single dominant ventricle supports both pulmonary and systemic circulation. Advances in ...

Lifelong Management of Right Ventricular Outflow Tract Dysfunction in Adults with Congenital Heart Disease.

Right ventricular outflow tract (RVOT) dysfunction is a common and clinically significant late complication in adults with congenital heart disease (ACHD), often after repair of conotruncal anomalies,...

MRI-Guided Magnetic Micro/Nanorobots for Precision Neurotherapeutics: From Intelligent Navigation and BBB Penetration to Clinical Translation.

The rapid advancements in nanotechnology and medical imaging have positioned magnetic resonance imaging (MRI)-guided magnetic micro/nanorobots (MNRs) as a promising platform for integrated diagnosis a...

Magnetic Nanoparticles as a Theranostic Platform in Brain Tumor Treatment: Surmounting the Bench-to-Bedside Barriers.

Malignant brain tumors, particularly glioblastoma, remain one of the greatest challenges in oncology due to their invasive nature, therapeutic resistance, and protection by the blood-brain barrier. De...

Nanomedicine for Depression: From Blood-Brain Barrier Delivery to Neuroimmune-Barrier-Plasticity Network Reprogramming.

Depression is a heterogeneous and recurrent brain disorder in which neuroinflammation, blood-brain barrier dysfunction, oxidative and mitochondrial stress, and impaired neuroplasticity interact within...

Remodeling of muscular component of the myocardial tissue depending on age, sex and cause of death.

AIM: Ageing process, as well as different pathological conditions, can induce morphological and functional changes in all tissue including those of cardiovascular system and particularly in myocardial...

Evaluating a Novel Cell-Free Preservation Solution for Human Cardiomyocyte Protection: A Proof-of-Concept Study.

BACKGROUND: Heart transplantation remains the definitive therapy for end-stage heart failure; however, its clinical impact is constrained by donor availability and preservation-associated injury. Stat...

Efficacy of combined modality conversion therapy for HCC with portal vein tumor thrombus: a retrospective cohort study.

BACKGROUND: Unresectable hepatocellular carcinoma (uHCC) patients with portal vein tumor thrombus (PVTT) have a substandard prognosis. This study elucidated whether conversion therapy can alleviate un...

Evaluation of retinal and choroidal microvasculature parameters by OCTA in patients with premature ovarian insufficiency: a prospective case control study.

OBJECTIVE: Postmenopausal cohorts show reduced vessel density on optical coherence tomography angiography (OCTA), yet OCTA data specific to premature ovarian insufficiency (POI) are lacking. We aimed ...

NOX2 inhibition attenuates oxidative stress and eNOS uncoupling in pulmonary arteries of rats following simulated air diving.

Simulated diving and decompression can impair endothelial function, but the upstream oxidant sources and their relationship with endothelial nitric oxide synthase (eNOS) coupling in the pulmonary circ...

Obesity-Associated Cardiac Fibrosis: Mechanisms and Emerging Therapeutic Targets.

Obesity and cardiovascular disease are major, globally prevalent, and closely interrelated health challenges. Cardiac fibrosis represents the common pathological endpoint of multiple cardiac diseases....