The gut-liver-kidney-brain axis in Wilson disease: copper speciation-flux and barrier-mediated organ crosstalk.
Wilson disease (WD) has long been framed as a hepatocentric disorder of copper accumulation. That view is now giving way to a broader model centered on the gut-liver-kidney-brain axis. In WD, copper i...
The role of the bidirectional regulatory network between immune cells and stromal cells in cardiac repair and fibrosis following myocardial infarction.
Heart failure following myocardial infarction (MI) is a major complication affecting long-term prognosis of patient, with its core pathological processes being ventricular pathological remodeling and ...
Development of Nucleic Acid-Loaded Nanobubbles for Ultrasound-Mediated Therapeutic Applications.
Ultrasound has attracted considerable attention not only as a diagnostic imaging modality but also as a physical trigger for drug delivery system (DDS). Ultrasound irradiation applied in combination w...
Lateralized cerebral arterial blood flow and blood pressure adaptations to short-term head-down tilt: a 4D flow MRI study with cognitive function assessment.
BACKGROUND: Simulated microgravity, modeled by head-down tilt (HDT), induces cephalad fluid shifts that perturb intracranial hemodynamics and may affect cognitive function. However, the temporal adapt...
Brain Endothelial Glycocalyx as a Blood-Facing Translational Interface in Alzheimer's Disease: Beyond "Leaky" Barriers Toward Repair-First Stratification.
Alzheimer's disease (AD) pathogenesis is increasingly recognized as involving blood-brain barrier (BBB) and neurovascular unit (NVU) destabilization. The brain endothelial glycocalyx-a blood-facing gl...
Validation of deep learning enabled software MetronMind to measure vertebral heart size and vertebral left atrial size in dogs.
BACKGROUND: Vertebral heart size (VHS) and vertebral left atrial size (VLAS) are objective radiographic measurements of heart and left atrial size, respectively and are associated with inter- and intr...
Varicella-zoster virus infection of the central nervous system: clinical features and proteomic analysis of cerebrospinal fluid.
OBJECTIVE: Varicella-zoster virus (VZV) involvement of the central nervous system (CNS) can cause severe complications; however, the underlying pathogenic mechanisms remain incompletely understood. Th...
Meningeal immunity and "Interstitial" therapy: a new paradigm for immunotherapy in glioblastoma.
Glioblastoma (GBM) is one of the most aggressive brain tumors, and its immunotherapy faces significant challenges, including the physical barrier of the blood-brain barrier, the tumor immunosuppressiv...
Case Report: Metastatic right ventricular tumor and pulmonary embolism from cervical cancer post COVID-19 infection.
The intracavitary cardiac metastasis from squamous cell carcinoma of the uterine cervix combined with pulmonary embolism is extremely rare, with mean survival less than six months. We report a case of...
Glycocalyx disruption mediates HP-PRRSV-induced microvascular endothelial dysfunction and underlies astragalus polysaccharide's antiviral efficacy.
BACKGROUND: Pulmonary microvascular endothelial cells (MVECs) are not only targets of the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) but also the pivotal hub of i...
Feasibility and findings of different radiographic methods in diagnosing canine heartworm disease.
BACKGROUND: Heartworm disease (HWD) represents the pathological consequences of heartworm (HW) (Dirofilaria immitis) infection on different organs and organ systems, primarily the lungs and heart. Rad...
Transplantation of human umbilical mesenchymal stromal cells attenuates heart failure progression in a rat model.
Myocardial infarction (MI), mainly caused by coronary artery occlusion, remains a leading cause of death worldwide. Although many patients survive after emergency treatment, chronic MI often develops,...
Dexamethasone restores blood-brain barrier integrity in an in vitro heatstroke model.
Heat-related diseases and their treatments are becoming the center of focus due to global warming resulting in rising global temperatures. Heatstroke is the most hazardous condition of heat-related di...
Cardiomyocyte-derived USP20 mitigates myocardial ischemia/reperfusion injury through deubiquitinating GRP78.
UNLABELLED: Myocardial ischemia/reperfusion (I/R) injury remains a major clinical challenge characterized by cardiomyocyte loss and adverse remodeling after reperfusion. Ubiquitin-Specific Peptidase 2...
Ion-Responsive Microneedles Delivering Subtype-Specific Mitochondrial Extracellular Vesicles from HEY1⁺ Cardiomyocytes for Cardiac Repair in Bama Minipigs with Myocardial Ischemia-Reperfusion Injury.
The pathogenesis of myocardial ischemia-reperfusion (MI/R) injury is intricately linked to mitochondrial dysfunction occurring during both the ischemic and reperfusion phases. Through single-cell tran...
NOD1 is a key mediator of atrial myopathy in heart failure.
UNLABELLED: Heart failure (HF)-associated atrial myopathy is driven by complex and poorly understood mechanisms. Emerging evidence suggests that innate immune components contribute to atrial remodelin...
Ultrasound targeted fatty acid nitroalkene-containing lipid nanoparticles attenuate inflammation and reverse myocardial fibrosis.
RATIONALE: Myocardial ischemia-reperfusion injury (MIRI) induces oxidative stress and inflammatory signaling that drive fibroblast activation, myocardial fibrosis, and progressive cardiac dysfunction,...
A Brain-Targeted Organophosphorus Hydrolase Fusion Protein Mediated by Angiopep-2 Neutralizes Central Organophosphates and Alleviates Neurotoxicity.
PURPOSE: Organophosphates (OPs) exert neurotoxicity by inhibiting acetylcholinesterase (AChE) activity, leading to acetylcholine accumulation, excessive nervous system stimulation, and even fatal outc...
Efficacy of an Integrated Nursing Protocol for the Management of Postoperative Upper Limb Circulatory Complications Following Transradial Coronary Intervention.
ObjectiveThe aim of this study was to assess the effectiveness of an integrated, evidence-based nursing protocol combining traditional Chinese and Western medicine for the management of upper limb cir...
[Impairment of retinal and choroidal blood flow autoregulation in preeclampsia].
Preeclampsia is a leading cause of maternal and perinatal mortality, which makes the search for methods of early preclinical diagnosis highly relevant. Ocular microcirculation, owing to its similarity...