Post-Heart Transplantation Intensive Care Unit Recovery: A Phase-Based Approach.
Heart transplantation is the definitive treatment for end-stage heart failure. Post-transplant care is dynamic and complex, requiring a thoughtful multidisciplinary approach. Invasive hemodynamic moni...
Medical Management and Mechanical Circulatory Support Escalation in Right Ventricular Failure.
Right ventricular (RV) failure is a clinically distinct entity with significant prognostic implications across multiple cardiovascular conditions. Its diagnosis is challenging due to overlapping featu...
A Practical Guide to Intensive Care Unit Management after Left Ventricular Assist Device Implantation.
Durable left ventricular assist devices (LVADs) have transformed the management of advanced heart failure, but early post-operative management remains a time of heightened vulnerability with dispropor...
Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.
OBJECTIVE: Obesity is a well-known heart failure (HF) risk factor, yet the biological pathways linking adiposity indices to HF remain unclear. This study aimed to identify proteomic mediators for five...
Targeted Plasma Amino Acid Metabolic Remodeling and Pharmacological Regulation in Heart Failure Rats Using PRISE-NUS-bs-HSQC 2D NMR Spectroscopy.
Nuclear magnetic resonance (NMR) metabolomics offers a robust platform for the analysis of complex biological samples, but its application is often constrained by signal overlap and limited sensitivit...
Early-Onset Obesity and Heart Failure Burden Independent of Cardiometabolic Risk Factors.
The timing of obesity onset may influence long-term cardiovascular risk. Whether obesity beginning in early adulthood differs from obesity acquired later in life with respect to cardiometabolic and ca...
Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review).
Cardiorenal syndrome (CRS) encompasses the bidirectional and complex interaction between cardiac and renal dysfunction. The present review focuses on CRS types 3 and 4, highlighting the negative effec...
Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis.
Heart failure with preserved ejection fraction (HFpEF) is a common cardiovascular disorder characterized by a left ventricular ejection fraction of ≥45%, which is typically accompanied by diastolic dy...
Associations of dietary inflammatory and antioxidant indices with mortality in adults with cardiovascular-kidney-metabolic syndrome: A mediation analysis.
Cardiovascular-kidney-metabolic (CKM) syndrome carries high mortality risk. Whether A Body Shape Index (ABSI), Weight-Adjusted Waist Index (WWI), Systemic Inflammation Response Index (SIRI), and Syste...
Admission serum bicarbonate is associated with early diuretic resistance in acute decompensated heart failure.
BACKGROUND: Acute decompensated heart failure (ADHF) exhibits a heterogeneous diuretic response. Chloride-bicarbonate imbalances may reduce loop diuretic efficiency. The effect of admission bicarbonat...
Cardiovascular outcome of glucagon-like peptide-1 receptor agonists vs dipeptidyl peptidase-4 inhibitor on end-stage kidney disease patients with heart failure: an emulated target trial in patients with diabetes.
Patients with end-stage kidney disease (ESKD) receiving maintenance dialysis have a high burden of heart failure (HF), with cardiovascular disease the leading cause of death, yet are largely excluded ...
Effectiveness and safety of acetazolamide plus loop diuretics in acute congestive heart failure: A living systematic review - Version 2026 1.0.
OBJECTIVE: This living systematic review Version 1.0 aims to provide a timely, rigorous and continuously updated summary of the evidence on the use of acetazolamide plus loop diuretics in acute conges...
Heart Failure with Preserved Ejection Fraction in Women: Sex-Specific Insights Across the Continuum from Diagnosis to Outcomes.
PURPOSE OF REVIEW: This review highlights differences in pathophysiologic mechanisms, diagnostic challenges and therapeutic responses of heart failure with preserved ejection fraction (HFpEF) in women...
Association between kidney stones and major adverse cardiovascular events: a population-based analysis.
Kidney stones are an increasingly common condition, and evidence suggests a link between stone formation and cardiovascular risk. This study aimed to investigate the association between kidney stones ...
Development and Internal Validation of the Soluble ST2, Age, and Estimated Glomerular Filtration Rate-Heart Failure Score for Predicting 30-Day Major Adverse Cardiovascular Events After Heart Failure Hospitalization in a Two-Center Vietnamese Cohort: Prospective Cohort Study.
BACKGROUND: Patients hospitalized for heart failure (HF) face a high-risk early postdischarge period. OBJECTIVE: We aimed to develop and internally validate the soluble ST2, age, and estimated glomeru...
Feasibility of a Mobile-Based Home Monitoring System for Patients With Heart Failure: Mixed Methods Pilot Study.
BACKGROUND: The risk of rehospitalization in patients with heart failure (HF) has initiated various efforts to prevent and simultaneously improve quality of life. Self-monitoring at home is one option...
The ManageHF Just-in-Time Adaptive Mobile App Interventions to Promote Self-Management and Improve Outcomes in Heart Failure: Randomized Controlled Trial.
BACKGROUND: Heart failure (HF) is a major health care challenge in the United States, with approximately 900,000 older adults hospitalized annually. Gaps in self-management, including unrecognized wor...
FOSL2 Regulates PANoptosis in Cardiomyocytes and Heart Failure Progression After Acute Myocardial Infarction by Promoting NLRP12.
NLRP12 can induce PANoptosis, a novel form of inflammatory cell death. The research aimed to investigate the mechanisms of NLRP12 in regulating PANoptosis during postinfarction heart failure (HF). C57...
Glucagon-like Peptide-1 Receptor Agonists and Dual Incretin Therapies Across HFpEF and Cardiovascular Outcomes Trials in Patients with Obesity.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and emerging dual incretin therapies have demonstrated substantial effects on weight reduction and metabolic improvement, with growing evidence su...
Association of the cardiometabolic index and depressive symptoms with cardiovascular disease in cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study.
The progressive nature of cardiovascular-kidney-metabolic syndrome (CKM) allows early intervention during stages 0-3. However, the role of the cardiometabolic index (CMI) across CKM stages 0-3 and its...