Resveratrol Ameliorated Hyperlipidemia: Association with Modulation of the Gut Microbiota and Bile Acid Metabolism.

Background: Hyperlipidemia represents a pivotal risk factor for multiple cardiovascular and metabolic diseases, creating an urgent demand for safe, effective novel therapeutic interventions. Resveratr...

Dyslipidemia-Induced Mitochondrial Dysfunctions in the Brains Does Not Reach Pathological Levels in the ApoE-Knockout Mice.

Although dyslipidemia and lipid accumulation are established risk factors for numerous neurological diseases, including stroke and neurodegenerative disorders, whether dyslipidemia directly causes neu...

Sterol biosynthesis, brain development, and disease.

Cholesterol biosynthesis is indispensable for CNS development and function. The developing brain relies almost entirely on intrinsic sterol synthesis to support membrane biogenesis, axonal outgrowth, ...

Post-Marketing Nutrivigilance of Red Yeast Rice-Containing Food Supplements: Spontaneous Adverse Event Reports and Exposure-Based Reporting Rate Estimates.

Background and Objectives: Red yeast rice (RYR)-containing food supplements are widely used for mild-to-moderate hypercholesterolemia, but their post-marketing safety remains relevant. This study char...

Chronic Pruritus in Predialysis Chronic Kidney Disease: Prevalence, Phenotype and Temporal Patterns in a Prospective Cohort.

CKD-associated pruritus (CKD-aP) is a burden some symptom with incompletely understood pathophysiology and limited predialysis data. In this prospective observational study, 95 adult nondialysis CKD p...

Non-HDL Cholesterol as a Practical Gatekeeper for Adolescent Dyslipidemia Screening: Implications for Nutrition and Public Health.

Dyslipidemia in adolescents represents an early and potentially modifiable stage in the lifelong trajectory of cardiovascular disease. However, optimal lipid screening strategies in this age group rem...

[Comment on the article: "Changes in the triglyceride-glucose index after one year of antiretroviral therapy"].

Both HIV diagnosis and antiretroviral therapy (55.1%) increase the risk of developing lipid profile abnormalities. This has led the European Society of Cardiology, in its 2025 update on the management...

The Angiopoietin-like Protein (ANGPTL) Axis in Dyslipidemia: Mechanisms, Cardiovascular Risk, and Emerging Therapies.

PURPOSE OF REVIEW: The angiopoietin-like protein (ANGPTL) 3-4-8 axis has emerged as a central regulator of lipoprotein lipase and lipid metabolism. This review examines the mechanistic basis of ANGPTL...

[Effects of exposure to ambient fine particulate matter on dyslipidemia and modifying role of dietary factors in children and adolescents in rural China].

Objective: To analyze the association between fine particulate matter (PM2.5) exposure and dyslipidemia, and the potential modifying role of dietary factors in children and adolescents in rural China....

Machine learning-based evaluation of lipid biomarkers for cardiovascular risk prediction in chronic kidney disease: A cross-sectional study.

Chronic kidney disease (CKD) is an important public health issue globally, greatly increasing the prevalence and mortality of cardiovascular disease (CVD). Dyslipidemia is a prevalent metabolic diseas...

[Analysis of gene variant spectrum associated with Familial hypercholesterolemia in a regional population: A retrospective study based on exome sequencing of 15 841 cases].

OBJECTIVE: To explore the genetic variant spectrum and epidemiological characteristics of Familial hypercholesterolemia (FH) patients in a regional population. METHODS: A retrospective analysis was ca...

Effects of Dietary Protein Quantity, Source, and Type on Plasma Lipids and Lipoproteins and Their Roles in Dyslipidemia Management in Humans.

Evidence from clinical trials indicates that dietary protein plays an important and often underappreciated role in lipoprotein lipid metabolism. For this narrative review, literature searches were con...

A novel pathogenic synonymous DHCR7 variant unveiled by aberrant splicing in Smith-Lemli-Opitz syndrome.

Synonymous mutations, once regarded as silent, are increasingly recognized as pathogenic through disruption of mRNA splicing. Here, we report a prenatal case with classic features of Smith-Lemli-Opitz...

Associations of Serum 25-Hydroxyvitamin D Concentrations and Lipid Profiles Across Adiposity Status Among Children and Adolescents Aged 9-17 Years: A Cross-Sectional Study in Guangzhou, China.

Background: Childhood dyslipidemia often tracks into adulthood and contributes to early atherosclerotic changes. Although serum 25-Hydroxyvitamin D (25(OH)D) has been implicated in lipid metabolism, f...

The Spectrum of Genetic Causes of Familial Hypercholesterolemia Phenotype.

PURPOSE OF REVIEW: This paper reviews the genetic spectrum underlying the Familial Hypercholesterolemia (FH) phenotype, aiming to improve diagnosis, awareness and understanding of these inherited lipi...

Clinical Practice Guideline on the Pharmacological Management of Antipsychotic-Related Dyslipidemia.

BACKGROUND: People taking antipsychotic medicines and those with severe mental illness experience elevated cardiovascular risk compared to the general population which is not adequately addressed by e...

Indoxyl Sulfate, a Gut Microbiota-Derived Metabolite, Modulates Hepatic Cholesterol Metabolism via SREBP-2/HMG-CoA Reductase Upregulation in Rats.

BACKGROUND: A high-fat diet (HFD) contributes to cardiometabolic disease. Gut microbiota-derived metabolites may participate in this process, but their contribution to lipid regulation is not well def...

Systematic Evaluation of the Nutritional Quality, Elemental Safety, and Preventive Effects of Perilla Seed Oil on Hyperlipidemia and Gut Microbiota Dysbiosis in High-Fat Diet-Fed Rats.

Background: Perilla seed oil (PSO) is a high-nutritional-value oil and widely used in functional foods, and derives from the mature seeds of Perilla frutescens. This study aimed to systematically eval...

Association of admission lactate dehydrogenase-to-albumin ratio with acute pancreatitis recurrence after first-episode hypertriglyceridemia-induced acute pancreatitis: A multicenter retrospective cohort study.

ObjectiveHypertriglyceridemia-induced acute pancreatitis (HTG-AP) has a high recurrence rate, and recurrent episodes may result in repeated hospitalizations and long-term pancreatic complications. Sim...

Family-based interventions for optimal lipid outcomes in adults: A cluster randomized controlled trial in India.

BACKGROUND: Dyslipidemia substantially increases the risk of cardiovascular disease (CVD), particularly among those with a strong family history. OBJECTIVE: To evaluate the longitudinal impact of the ...