Association of ultra-processed foods (UPFs) with hypertriglyceridemic waist (HTGW) phenotype, oxidative stress, and inflammation in Iranian adults: a cross-sectional study.
In this study, we evaluated the association between UPFs with HTGW in relation to oxidative stress and inflammation in Iranian adults, as no previous study had assessed these altogether. This cross-se...
Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia.
High levels of low-density lipoprotein cholesterol (LDL-c) have been recognized as the main causal factor of atherosclerotic cardiovascular disease (ASCVD) and are influenced by both genetic and envir...
Genetic Determinants of Severe Hypertriglyceridemia: Rare Variants in LPL, APOC2, APOA5, GPIHBP1, LMF1, APOE and Polygenic Risk.
Severe hypertriglyceridemia (HTG) is genetically heterogeneous, but its genetic architecture remains incompletely characterized. We investigated the genetic determinants of severe HTG in 123 patients ...
Discordant high remnant cholesterol with LDL-C increases the metabolic dysfunction-associated steatotic liver disease risk in patients with type 2 diabetes mellitus.
INTRODUCTION: Type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) frequently coexist in the same individual. Dyslipidemia plays a central role in the p...
Cross-interference of hemolysis, icterus and lipemia: A study with real patient samples.
INTRODUCTION: Hemolysis, icterus, and lipemia (HIL) are frequent preanalytical interferences, leading to erroneous results or sample rejection. While individual effects of these indices have been stud...
Distinct From the Adult Paradigm: Re-Evaluate the Pathophysiological and Therapeutic Framework in Children and Adolescent Hyperlipidaemia.
PURPOSE OF REVIEW: This review aims to summarize current advances in children and adolescent hyperlipidemia, and re-evaluate the unique epidemiology, genetic and environmental causes, and pathophysiol...
Effect of a culturally adapted heart-healthy diet with phytosterols and/or krill oil on lipid-related outcomes in familial hypercholesterolaemia: protocol for a multicentre randomised controlled trial in Brazil.
INTRODUCTION: An affordable heart-healthy dietary approach is essential for the management of familial hypercholesterolaemia (FH); however, the optimal dietary pattern and the role of adjunctive nutri...
Menopause age and hypercholesterolemia comorbidities: a region-wide retrospective cohort study in Andalusia, Spain (2016-2022).
OBJECTIVES: To quantify sex- and age-related differences in hypercholesterolaemia diagnosis and associated comorbidities around the menopausal transition, using a population-based real-world dataset. ...
Familial Hypercholesterolemia in Women: Diagnosis, Treatment, and Cardiovascular Outcomes Across the Lifespan.
PURPOSE OF REVIEW: Familial hypercholesterolemia (FH) is a common monogenic lipid disorder, characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) and a markedly increased risk...
Nocturnal Hypoxic Exposure Combined with Two-Week Hypoxic Training and Calorie Restriction Improves Lipid Profile and Body Composition in Men with Obesity-Related Hypercholesterolemia: A Controlled Intervention Study.
Despite advances in lifestyle-based therapy, achieving clinically meaningful reductions in blood lipid levels remains a major challenge in obese men with secondary hypercholesterolemia. Hypoxic exposu...
Cost-effectiveness of genome-guided statin treatment for hypercholesterolemia.
Cardiovascular disease and hypercholesterolemia present significant global health and economic burdens. While statins are the standard treatment, individual variability and toxicities necessitate pers...
Identifying a Safety Threshold for Parenteral Glucose Intake in the Early Acute Phase of Preterm Neonates.
Background/Objectives: The safety of specific parenteral glucose intake values within the range currently recommended by international guidelines for the early acute phase in preterm neonates has not ...
Translating Lipoprotein Genetics Into New Therapies.
Human genetics has become the primary engine for identifying lipid-lowering drug targets and predicting therapeutic success or failure. Monogenic family studies and population-based sequencing identif...
Effect of Oat Flakes on Glycemic Variability, Dyslipidemia, and Pancreatic Duodenum Homeobox-1 (PDX-1) Level Among Adolescents with Type 1 Diabetes: A Randomized Crossover Study.
Aims: Murine studies show a promising effect of high-fiber β-glucan on glycemic control and serum lipids. In addition, β-glucan has recently been found to have strong antioxidant and immunomodulatory ...
LDL-cholesterol targets and lipid-lowering therapies - a plea to medical schemes and the Council for Medical Schemes.
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Adipose Tissue Inflammation, Oxidative Stress, and Altered Adipogenesis Are Associated With Dyslipidemia in Obesity: A Multiomics Profiling Study.
BACKGROUND: Obesity is an important risk factor for cardiometabolic disease, including dyslipidemia and atherosclerotic cardiovascular disease. Although the role of the liver in dyslipidemia is establ...
Clinical severity of pulmonary Tuberculosis (TB) is associated with Hypocholesterolemia among adult patients in Uganda.
BACKGROUND: Hypocholesterolaemia in pulmonary tuberculosis(TB) patients is disregarded but is a predictor of poor survival. OBJECTIVES: To determine serum lipid profile differences at diagnosis and va...
Elevated FTX Expression in Polycystic Ovary Syndrome: Correlations With Insulin Resistance, Dyslipidemia, and Diagnostic Potential.
BACKGROUND: This study aims to investigate the expression changes of FTX (long noncoding RNA) in polycystic ovary syndrome (PCOS) and its relationship with insulin resistance and lipid metabolism, the...
Unripe Musa paradisiaca Peel Extract Improves Dyslipidemia and Cardiac Dysfunction in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Rats.
Plant-derived foods are rich in bioactive compounds with notable therapeutic potential. Plantain (Musa paradisiaca L.) is widely cultivated and traditionally used in managing inflammation and diabetes...
Hyperlipid-Related Alzheimer's Disease: Potential Role of CircUCK2/miR-24-3p/p38 Axis in Neuronal Damage.
BACKGROUND: Accumulating empirical evidence underscores that hyperlipidemia may fuel the pathological progression of Alzheimer's disease (AD) by triggering inflammatory signaling cascades and promotin...