[Mechanism of vitexin in treating acute hyperlipidemia by combination of metabolomics and network pharmacology].

The study aims to investigate the mechanism of vitexin in treating acute hyperlipidemia through a combination of network pharmacology, molecular docking, and metabolomics approaches. An acute hyperlip...

[Research advance on regulation of SREBP pathway by TCM in prevention and treatment of hyperlipidemia].

Hyperlipidemia(HLP) is a significant independent risk factor for the occurrence and development of cardiovascular and cerebrovascular diseases. Currently, the common clinical lipid-lowering agents inc...

[Epidemiological characteristics and changes of metabolic abnormalities among students aged 6-14 in Beijing in 2015 and 2019].

OBJECTIVE: To study the epidemiological characteristics and changes of central obesity, abnormal blood glucose, and dyslipidemia among students aged 6-14 in Beijing. METHODS: A multi-stage stratified ...

Development and validation of a predictive model for the severity of hyperlipidemic acute pancreatitis based on the bedside index for severity in acute pancreatitis and metabolic score for insulin resistance: A retrospective cohort study.

ObjectivesHyperlipidemic acute pancreatitis progresses rapidly to severe acute pancreatitis. Early identification of disease severity is critical for improving outcomes. This study aimed to investigat...

Genetic association of rs373001 polymorphism in mir-130b gene with susceptibility to dyslipidaemia and correlation with lipid profile.

OBJECTIVE: To find the association and correlation of rs373001 polymorphism in micro-ribonucleic acid-130b gene with the risk of dyslipidaemia. METHODS: The case-control study was conducted from April...

Hyperlipidaemia and its future prospective in district Gujrat, Pakistan: a retrospective study.

OBJECTIVE: To evaluate the prevalence of hyperlipidaemia with respect to age and gender, and to assess future prospects. METHODS: The retrospective study was conducted in October 2024 at Dr Abdul Rauf...

High-Density Lipoprotein Subfraction Analysis by High-Density Lipoprotein Cholesterol Levels and Gender in Healthy Adults.

BACKGROUND: Attempts to raise high-density lipoprotein cholesterol (HDL-C) levels pharmacologically have failed to reduce cardiovascular risk and some studies suggest that very high HDL-C levels may p...

Efficacy and Safety of Pemafibrate for the Treatment of Dyslipidaemia: A Meta-Analysis.

Elevated plasma triglyceride (TG) levels are recognised as a significant risk factor for cardiovascular disease. Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha (PPAR-α...

Sit-To-Stand Breaks to Optimize Cardiometabolic Health Effects Following Exercise in Sedentary Adults With Dyslipidaemia: A Randomized Crossover Trial.

Current physical activity (PA) guidelines recommend reducing prolonged sitting in addition to increasing PA. In this regard, the complementary effects of standing breaks to interrupt sitting, in addit...

Evaluation of High-Density Lipoprotein Capacity to Acquire Free Cholesterol From Triglyceride-Rich Lipoproteins During Reverse Remnant-Cholesterol Transport in Familial Hypercholesterolemia.

INTRODUCTION: High-density lipoprotein (HDL) serves as a key protective factor against elevated low-density lipoprotein cholesterol (LDL-C) levels in patients with familial hypercholesterolemia (FH). ...

[Bempedoic acid in real-world clinical practice: baseline and 8-week data from the Italian prospective, non-interventional MILOS study].

BACKGROUND: Bempedoic acid (BA), an adenosine triphosphate-citrate lyase inhibitor, effectively reduces LDL cholesterol (LDL-C) and cardiovascular (CV) risk, as demonstrated in randomized clinical tri...

Multimodal ophthalmic imaging in the search for the association between subretinal drusenoid deposits and systemic vascular comorbidity with metabolic dysregulation in age-related macular degeneration progression.

INTRODUCTION: Age-related macular degeneration (AMD) is increasingly linked to systemic cardiovascular and metabolic dysfunction as well as cerebral small vessel disease. Subretinal drusenoid deposits...

Lower Risk of Type 2 Diabetes Mellitus With PCSK9 Inhibitors Compared With Other Lipid-Lowering Agents Among Patients With Hyperlipidaemia.

AIMS: The purpose of this paper is to compare the risk of incident type 2 diabetes mellitus (T2DM) among patients with hyperlipidaemia treated with proprotein convertase subtilisin/kexin type 9 (PCSK9...

Alcohol Herbal Beverage and Ethanol Consumption in High-Fat Diet fed Rats Exacerbates Blood pressure, Insulin Resistance, dyslipidemia, and Cardio-hepatic inflammation.

The current study was designed to investigate the outcome of alcohol herbal beverages and ethanol consumption in high-fat diet-induced cardiometabolic syndrome (indices) in rats. The study consists of...

From Phenotype to Genotype and Beyond: Insights into Familial Hypercholesterolemia and Familial Hypertriglyceridemia.

Familial hypercholesterolemia (FH) and familial hypertriglyceridemia (FHTG) represent a spectrum of inherited conditions with profoundly different etiologies, risk profiles, and therapeutic implicatio...

Low-density lipoprotein cholesterol management and goal attainment at 1 year in patients with diabetes, pre-diabetes and normoglycaemia: results from the European, prospective, observational SANTORINI study.

OBJECTIVE: To assess changes in lipid-lowering therapy (LLT) use and low-density lipoprotein cholesterol (LDL-C) goal attainment through 1-year follow-up in patients stratified by diabetes status in S...

A case of lipoprotein glomerulopathy in which complete remission was achieved by pemafibrate therapy.

Lipoprotein glomerulopathy (LPG) is a rare hereditary glomerular disease characterized by lipoprotein thrombi within dilated glomerular capillaries for which effective treatments remain limited. This ...

Lipid Metabolic Disorders: a Pivotal Driver in Type 2 Diabetes Mellitus Pathogenesis.

PURPOSE OF REVIEW: This review aims to synthesize recent evidence to clarify the causal and mechanistic roles of lipid metabolism disorders as core drivers of type 2 diabetes mellitus (T2DM), and to s...

Serum Folate in Relation to Lipid Abnormalities in Community-Dwelling Adults: A Population-Based Cross-Sectional Study in Zhejiang Province, China.

Objectives: This study aimed to examine the cross-sectional associations between serum folate concentrations and four lipid abnormality subtypes among community-dwelling adults in Zhejiang Province, C...

Treatment and control of low-density lipoprotein for primary prevention in patients in Wales with and without depression: a study of whole-population electronic health records.

AIM: This study investigated the influence of depression status on lipid lowering therapy (LLT) prescribing and achievement of guideline targets for low density lipoprotein cholesterol (LDL-C) levels ...