Multimodal Machine Learning Integrating Clinical and Proteomic Data for Early Prediction of Hypertensive Complications: A UKB Longitudinal Study.

BACKGROUND: Hypertension is a leading risk factor for cardiovascular, cerebrovascular, and renal diseases, significantly worsening prognosis and quality of life. We aimed to develop and validate multi...

Model-informed dose optimization of carvedilol and nebivolol in cirrhotic patients: a pilot randomized clinical study.

Liver cirrhosis causes physiological and pharmacokinetic alterations that complicate antihypertensive therapy, in the presence of portal and arterial hypertension. This study evaluated the efficacy an...

[Initial disorders of pulmonary hemodynamics in patients with systemic sclerosis: the relevance of the new hemodynamic definition of pulmonary arterial hypertension].

AIM: To investigated the impact of the new hemodynamic definition of pulmonary arterial hypertension (PAH) as proposed by the 6th PH World Symposium on the phenotypes, outcome and survival in patients...

Serum Uric Acid as a Cardiovascular Risk Marker: Differential Effects of Ketogenic Diet and Intermittent Fasting in Postmenopausal Women.

BACKGROUND: Serum uric acid (UA) is increasingly recognized as a cardiovascular (CV) risk factor, with evidence suggesting that CV risk may occur at levels below conventional hyperuricemia thresholds....

Association between dietary thiamin, riboflavin and niacin intake and hypertension and increased pulse pressure: A cross-sectional study of the National Health and Nutrition Examination Survey 1999-2023.

This cross-sectional study aimed to examine the associations between total intake of 3 B vitamins (thiamin, riboflavin, niacin) and hypertension and increased pulse pressure in U.S. adults, and to exp...

Clinical effectiveness of telepharmacy services in patients with non-communicable diseases in ambulatory care settings.

RATIONALE: Non-communicable diseases (NCDs), such as hypertension, diabetes, and asthma, require continuous medication management. However, medication adherence remains suboptimal. Telepharmacy-define...

Barriers and facilitators to digital health tool adoption for hypertension management: systematic review of qualitative studies.

OBJECTIVES: Digital health interventions (DHIs) show considerable promise in supporting hypertension self-management by promoting preventative care and self-monitoring. While their efficacy is increas...

Combined Aldosterone Synthase and SGLT2 Inhibition: A Recipe for Success in CKD with Uncontrolled Blood Pressure?

PURPOSE OF REVIEW: To evaluate the emerging role of aldosterone synthase inhibitors (ASIs) in combination with sodium-glucose cotransporter 2 (SGLT2) inhibitors for the management of uncontrolled hype...

Ambulatory hypertension and left ventricular hypertrophy in pediatric chronic kidney disease: a systematic review and meta-analysis.

UNLABELLED: Cardiovascular disease is the leading cause of mortality in pediatric patients with chronic kidney disease (CKD). In the general pediatric population, hypertension is associated with an in...

mHealth for chronic disease management: effects on adherence in Ghanaian patients with diabetes and hypertension.

BACKGROUND: Medication non-adherence remains a major barrier to effective chronic disease management, particularly in low- and middle-income countries. In Ghana, limited access to continuous care and ...

From guidelines to practice: general practitioners' consensus on indicators for managing selected multimorbidity in primary care in Western Australia.

BACKGROUND: Multimorbidity is rising in primary care, yet adherence to guidelines is hindered by fragmented, disease-specific recommendations. This study sought to establish consensus among general pr...

Recognition, treatment, and control of hypertension in the Danish population-based Lolland-Falster Health Study.

In the Danish population-based Lolland-Falster Health Study (LOFUS), conducted in a socioeconomically disadvantaged area with marked regional health inequalities, we recently identified a hypertension...

Editorial for the Special Issue "Diabetes, Hypertension, and Cardiovascular Diseases: New Insights, Risk Factors, and Drug Therapies".

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide [...].

Age-related changes in METS-IR and HOMA-IR in obese adults and their relationship with cardiometabolic comorbidities.

OBJECTIVE: Insulin resistance (IR) is central to cardiometabolic risk in obesity, but the clinical utility of IR indices may vary by age. We compared homeostasis model assessment for insulin resistanc...

Sex-dependent differences in mitochondrial protein acetylation in metabolic condition, oxidative stress, vascular dysfunction, hypertension, and cardiovascular disease.

One half of adults have hypertension, which is a major risk factor for stroke, myocardial infarction, heart failure, and vascular dementia. There is an urgent need for new therapies, particularly for ...

Association between Atherogenic Index of Plasma and Hypertension in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome-A Retrospective Study.

This study aimed to investigate the relationship between the atherogenic index of plasma (AIP) and hypertension in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). A total of 381 OSAHS...

Joint Associations of Multidimensional Socioeconomic Status and Healthy Lifestyle with Prevalent Hypertension: A Large Population-Based Study in Northwest China.

Background/Objectives: The roles of healthy lifestyle and socioeconomic status (SES) in prevalent hypertension, as well as their joint patterns, remain incompletely understood. This study examined the...

The emerging function of MYPT1 as a biomarker and therapeutic target.

Recent research suggests that isoforms of myosin phosphatase target subunit 1 (MYPT1) may influence blood pressure regulation by altering smooth muscle responsiveness and, as a result, the function of...

Comparing bridging drug therapy approaches prior to balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: a prospective analysis from the national UK CURATE registry.

BACKGROUND: Pulmonary hypertension (PH) medical therapies are commonly used as a bridge to balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic PH (CTEPH) but their effectivenes...

Association between hypertension status and severity and tinnitus: a cross-sectional analysis of the Fasa adult cohort study.

BACKGROUND: Previous studies and meta-analyses suggest an association between hypertension and tinnitus; however, the influence of hypertension severity and control status remains unclear. OBJECTIVE: ...