Endothelial c-IAP2 loss amplifies P2X7 receptor-driven inflammation and worsens schistosomiasis-associated pulmonary hypertension.

Schistosomiasis-associated pulmonary hypertension (Sch-PH) is the most common form of group I PH worldwide. Recently, data revealed that the preclinical Sch-PH animal model exhibited gut and lung micr...

Transcriptomic Identification of Renin-Angiotensin System-Related Candidate Biomarkers and External Testing of a Hypertension Diagnostic Model.

This work aimed to identify candidate renin-angiotensin system (RAS)-related blood transcriptomic biomarkers associated with hypertension, construct an externally tested candidate diagnostic model, an...

Skin tone and diagnostic equity in contactless blood pressure screening: a prospective observational field evaluation of remote photoplethysmography in Nigeria.

OBJECTIVES: To evaluate diagnostic equity, feasibility and acceptability of a remote photoplethysmography-based blood pressure screening application among adults with darker skin tones in Nigeria. DES...

The Research Progress in Targeted Therapy for Hypertension via Heat Shock Proteins.

As the core molecular chaperones of the cellular stress response, the heat shock protein (HSP) family has gained extensive attention for its role in the occurrence, development, and target organ damag...

Association of family history of hypertension with preventive attitudes and quality of life in turkish population: A cross-sectional study.

Hypertension is more common among patients with a family history of hypertension (FHH). However, it is not known whether FHH is associated with hypertension-preventive attitudes in normotensive indivi...

Can shortening the waiting time for gestational hypertension and preeclampsia during labor reduce adverse outcomes of conversion to cesarean section?: A retrospective cohort study.

This study aims to investigate the threshold effect of labor duration on adverse outcomes associated with cesarean sections in pregnant women with gestational hypertension and preeclampsia (GH-PE). Th...

Exploring associations between epidemiological risk factors and colorectal cancer in Oman: a case-control study.

OBJECTIVES: To identify risk factors and examine associations between colorectal cancer (CRC) status and modifiable and non-modifiable risk factors among patients diagnosed in Oman, considering the ex...

Clinical and laboratory characteristics of pediatric patients diagnosed with thyroid hormone resistance: A single-center experience.

BACKGROUND: Thyroid hormone resistance β (RTHβ) is a rare genetic disorder characterized by reduced tissue responsiveness to thyroid hormones. This study aimed to describe the clinical, biochemical, a...

Long-term effects of weight-reducing drugs in people with hypertension.

RATIONALE: Long-term weight management drugs have the potential to reduce body weight and blood pressure in obese or overweight individuals. Being overweight or obese is often associated with hyperten...

Protocolos Nacionales de Atención Médica: marco para fortalecer la atención de primer nivel en México.

OBJETIVO: Describir el proceso de desarrollo y las características principales de los Protocolos Nacionales de Atención Médica (PRONAM), una estrategia nacional para estandarizar la práctica clínica e...

Cost-effectiveness-oriented management (CEOM) of cardiovascular risks at primary healthcare settings in Anhui, China: a protocol for a cluster randomised controlled trial.

INTRODUCTION: Cardiovascular disease (CVD) represents a significant health and economic burden in China. Despite extensive research on CVD management in primary care, the cost-effectiveness of current...

The role of metabolic health in neurostructural and cognitive alterations in bipolar disorders.

BACKGROUND: Bipolar disorders (BD) rank among the most disabling conditions, affecting millions worldwide. Cognitive impairment in BD is linked with brain changes and worse functional outcomes. Obesit...

KNG-1, HSPG and Robo4 reflect hypertension-driven subclinical renal alterations and provide incremental diagnostic value in type 2 diabetic nephropathy.

Diabetic nephropathy (DN), indicated by persistent urinary albumin excretion or albuminuria, is the major cause of end stage renal disease worldwide. Currently albuminuria is considered the best predi...

Pathophysiological Mechanisms and Clinical Controversies of Sodium-Induced Hypertension: A Multi-Systemic Perspective.

Hypertension remains the primary modifiable driver of global cardiovascular morbidity, yet the long-standing paradigm of universal sodium restriction is increasingly challenged by the intricate biolog...

Pulmonary Immune Cell Landscape Altered by Exposure to HIV, Schistosoma and Their Combination.

Local immune cell activation and vascular remodelling are characteristic pathogenic features of pulmonary arterial hypertension (PAH). HIV and schistosome infections have been individually associated ...

Antihypertensive Peptide ENWAAL Derived from Coix Glutelin and Its Effect on the Expression of SHR Renin-Angiotensin System.

Hypertension is one major risk factor of cardiovascular diseases, and RAS plays vital role during the development of hypertension. To obtain a novel antihypertensive peptide, Coix glutelin was hydroly...

Beyond PVR: dynamic physiologic assessment enhances prognostic evaluation in pulmonary hypertension associated with chronic obstructive pulmonary disease.

OBJECTIVES: Pulmonary hypertension associated with chronic obstructive pulmonary disease (PH-COPD) is associated with poor outcomes, yet resting haemodynamics incompletely capture disease severity. We...

SREBP gene polymorphisms and ambulatory blood pressure parameters in Chinese adolescents: a cross-sectional study.

UNLABELLED: The purpose of this study was to investigate the association between SREBP gene polymorphisms and ambulatory blood pressure phenotypes. In the present study, 514 college students from a un...

Identifying Contextual Barriers and Potential Solutions to Improving Hypertension Management in Rural Communities in the United States: Qualitative Study From 2 North Carolina Counties.

BACKGROUND: Blood pressure-related deaths from cardiovascular disease are higher in rural than in urban areas in the Unites States, especially in southeastern states. However, the barriers and potenti...

Three-Year Durability of Radiofrequency Renal Denervation: SPYRAL HTN-ON MED.

BACKGROUND: The SPYRAL HTN-ON MED (Global Clinical Study of Renal Denervation With the Symplicity Spyral Multielectrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard ...