Serial Strain-Based Echocardiographic Characterization of Early Left Heart Functional Changes During Short-Term Mavacamten Treatment in Obstructive Hypertrophic Cardiomyopathy.
PURPOSE: To characterize early left heart functional changes during short-term mavacamten use in a real-world obstructive hypertrophic cardiomyopathy (oHCM) cohort using serial strain-based echocardio...
The Triglyceride-Glucose Index Combined With Obesity Indices and Lower Extremity Artery Disease in Type 2 Diabetes: A Sex-Stratified Analysis.
BACKGROUND: Lower extremity artery disease (LEAD) is highly prevalent among people with type 2 diabetes mellitus (T2DM) in China. This study aimed to investigate the associations of the triglyceride-g...
Conditional knockout of membrane-type I matrix metalloproteinase in smooth muscle cells of adult mice alleviates atherosclerosis without affecting basic cardiovascular function.
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality worldwide. Despite effective lipid-lowering treatments, substantial residual risks remain. In...
Comparative effectiveness of tirzepatide and DPP-4 inhibitors in type 2 diabetes with heart failure.
While patients with type 2 diabetes mellitus (T2DM) and heart failure (HF) are frequently prescribed dipeptidyl peptidase-4 inhibitors (DPP-4is), emerging evidence suggests glucagon-like peptide-1 rec...
Acute Left Heart Failure in Twin Pregnancies: Clinical Characteristics and Outcomes-A 10‑Year Retrospective Analysis of 24 Cases.
This retrospective study evaluated the clinical characteristics, management, and maternal-neonatal outcomes of 24 twin pregnancies complicated by acute left heart failure (ALHF) delivered at Peking Un...
A 67-Year-Old Woman With Intractable Cough and Dyspnea After Catheter Ablation for Atrial Fibrillation.
A 67-year-old woman with diabetes mellitus, hypertension, and atrial fibrillation, but no smoking history, sought treatment for chronic cough, dyspnea, and intermittent expectoration of small, thread-...
Design, Synthesis, and Molecular Docking of Benzimidazole Derivatives as Angiotensin II AT1-Receptor Antagonists in a Hypertensive Rat Models.
High blood pressure is a major risk factor of cardiovascular disorders. Experimental models of hypertension play a critical role in elucidating its pathophysiological mechanisms and in evaluating nove...
Post-stroke acute heart failure in patients with large vessel occlusion undergoing endovascular treatment: A pooled analysis of individual patient data from multicenter studies with mediation analysis.
BACKGROUND: Cardiac complications rank among the leading contributors to poor outcomes in ischemic stroke patients along with the neurological impairment, while the risk stratification and prognostic ...
Entropy for Prediction of MACEs in Myocarditis: A Cardiac MRI-based Biomarker of Myocardial Tissue Heterogeneity.
Background The prognostic value of left ventricular (LV) entropy in acute myocarditis is unclear. Purpose To assess the association of LV entropy, a measure of myocardial heterogeneity derived from ca...
Hyperdense Capsule Sign at Noncontrast CT as an Indication for Middle Meningeal Artery Embolization for Nonacute Subdural Hematomas: A MAGIC-MT Trial Post Hoc Analysis.
Background Hematoma recurrence and progression remain common challenges in nonacute subdural hematomas (SDHs). The understanding of indications for middle meningeal artery embolization (MMAE) is limit...
High-Density Lipoprotein Subfraction Analysis by High-Density Lipoprotein Cholesterol Levels and Gender in Healthy Adults.
BACKGROUND: Attempts to raise high-density lipoprotein cholesterol (HDL-C) levels pharmacologically have failed to reduce cardiovascular risk and some studies suggest that very high HDL-C levels may p...
Association between a high total cholesterol-to-high-density lipoprotein cholesterol ratio and hyperuricemia among patients with hypertension: A cross-sectional study from central Uganda.
BackgroundHyperuricemia is a cardiometabolic risk factor among patients with hypertension. A high total cholesterol-to-high-density lipoprotein cholesterol ratio reflects atherogenic lipid imbalance a...
Comparing Ferric Carboxymaltose Versus Iron Sucrose in Patients with Heart Failure.
BACKGROUND: Limited evidence comparing different intravenous (IV) iron products is available to guide the optimal IV iron product in patients with heart failure (HF) and iron deficiency (IDef). OBJECT...
Isosmotic hypovolemia preserves inverse neurovascular coupling in the supraoptic nucleus during heart failure.
Vasopressin (AVP) neurons in the hypothalamic supraoptic nucleus (SON) are activated by systemic challenges that threaten fluid balance. We previously showed that a systemic salt challenge triggers in...
"A Case of Anomalous Systemic Venous Connections to Left Sided Atrium in Left Isomerism".
A 7-month-old infant with Tetralogy of Fallot physiology showed disproportionate left heart dilatation. Multisite saline contrast echocardiography demonstrated immediate left sided atrial opacificatio...
Potential Mechanisms of Trimetazidine and Coenzyme Q10 Against Antipsychotic-Induced Myocarditis: A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Study.
BACKGROUND: Antipsychotic-induced myocarditis is a rare but potentially fatal adverse event associated with antipsychotic treatment. Trimetazidine (TMZ) and coenzyme Q10 (CoQ10) have shown potential c...
Associations of the C-Reactive Protein-Albumin-Lymphocyte Index, Red Cell Distribution Width-Albumin Ratio, and Blood Urea Nitrogen-Albumin Ratio With All-Cause and Cardiovascular Mortality Among Adults With Preclinical Heart Failure.
BACKGROUND: Preclinical heart failure (PHF) is an early stage in the heart failure continuum, yet practical indices for mortality risk assessment remain understudied. HYPOTHESIS: The C-reactive protei...
Strauss-Defined LBBB Identifies Patients With Improved Outcomes After CRT-D: A Comparative Cohort Study.
BACKGROUND: Left bundle branch block (LBBB) is a well-established predictor of response to cardiac resynchronization therapy (CRT) in heart failure with reduced ejection fraction. However, several ele...
How to Replace the TQT Study-The Use of Concentration-QTc Modeling to Exclude a Small Effect of a Novel Drug on QT Interval: Historical Perspective and Implementation.
The initial ICH E14 guidance described the thorough QT/QTc (TQT) study with the purpose of evaluating whether a new drug has effects on the QTc interval. Following its adoption, concentration-QTc (C-Q...
Advancing Retinal Vessel Analysis: Reproducibility of Myogenic Constriction and Assessment of Regulatory Capacity.
PURPOSE: Accurate characterization of retinal microvascular autoregulation requires reliable assessment of both vasodilatory and vasoconstrictive responses. Although blood pressure (BP)-induced vasoco...