Efficacy and Safety of Pemafibrate for the Treatment of Dyslipidaemia: A Meta-Analysis.

Elevated plasma triglyceride (TG) levels are recognised as a significant risk factor for cardiovascular disease. Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha (PPAR-α...

Stress-hyperglycemia ratio, its longitudinal trajectories, and stress-metabolism synergy in predicting cardiometabolic multimorbidity: A nationwide prospective cohort study.

ObjectiveCardiometabolic multimorbidity is a major driver of chronic disease burden in aging Chinese populations. Conventional single disease risk scores cannot reliably identify those at high cardiom...

Integrated Care Models for HIV, Diabetes and Hypertension in Sub-Saharan Africa: A Systematic Review of Effectiveness, Implementation and Real-World Applicability.

BACKGROUND: Sub-Saharan Africa faces a syndemic of HIV and non-communicable diseases (NCDs), particularly diabetes and hypertension. Integrated care models have been promoted to improve service effici...

Visit-to-Visit Systolic Blood Pressure Variability Predicts Long-Term Cardiovascular Events After Coronary Artery Bypass Grafting.

This prospective observational study investigated whether systolic blood pressure variability (SBPV) during the transitional care period predicts long-term outcomes after coronary artery bypass grafti...

Utilisation of the Lactate/Albumin Ratio as a Mortality Predictor in Patients with Acute Heart Failure in the Emergency Department.

OBJECTIVE: To evaluate the effectiveness of the lactate/serum albumin (L/A) ratio in predicting 30- and 90-day all-cause mortality and 30-day all-cause readmissions in patients presenting to the emerg...

Risk Factors for 60-Day Rehospitalization Among Home Healthcare Patients With Heart Failure and Diabetes.

Heart failure (HF) is a complex chronic disease with multiple comorbidities, including diabetes. Patients with diabetes are at an increased risk of developing HF-a major adverse cardiovascular outcome...

Dexmedetomidine for the prevention of postoperative atrial fibrillation: A systematic review and meta-analysis.

ObjectivePostoperative atrial fibrillation, a prevalent complication following cardiac surgery, significantly increases patient morbidity and healthcare expenditures. Although dexmedetomidine has been...

Roles of Microglia in Cerebral Small Vessel Disease.

BACKGROUNDS: Cerebral small vessel disease (CSVD) is a major cause of vascular dementia, characterized by heterogeneous pathologies affecting the brain's microvasculature. In recent years, researchers...

Superficial Palmar Branch of the Radial Artery, Medial Plantar Artery Perforator, and Medial Sural Artery Perforator Free Flaps in Digital Soft Tissue Reconstruction: Comparisons of Clinical Outcomes From a Retrospective Institutional Series.

INTRODUCTION: Digital defects requiring soft tissue reconstruction are still challenging. There is no first-choice free flap for digital reconstruction, although various free flaps were used to recons...

Lymphovenous Anastomosis for Treatment of Breast Lymphedema Following Delayed Autologous Reconstruction: A Case Report.

Breast lymphedema (BLE) is an underrecognized sequela of breast cancer treatment that can lead to chronic swelling, pain, and recurrent infections. While lymphovenous anastomosis (LVA) is well establi...

Left Atrial Appendage Mechanical Dysfunction in De Novo Organized Left Atrial Tachyarrhythmia: A Multicenter Pre-Ablation Study.

PURPOSE: Whether de novo organized left atrial tachyarrhythmia (LAT) shows preserved left atrial appendage (LAA) mechanics has not been adequately characterized. We compared LAA peak emptying velocity...

Biomarkers for Diabetic Peripheral Artery Disease: An Integrated Review and Clinical Perspective.

Type 2 diabetes mellitus and peripheral artery disease are pathophysiologically interlinked through shared mechanisms such as chronic inflammation and endothelial dysfunction, highlighting the imperat...

Sit-To-Stand Breaks to Optimize Cardiometabolic Health Effects Following Exercise in Sedentary Adults With Dyslipidaemia: A Randomized Crossover Trial.

Current physical activity (PA) guidelines recommend reducing prolonged sitting in addition to increasing PA. In this regard, the complementary effects of standing breaks to interrupt sitting, in addit...

CAD-RADS 2.0 - Update on the evaluation and management of coronary artery disease with coronary CT angiography.

The updated Coronary Artery Disease Reporting and Data System (CAD-RADS 2.0) adds new features for patients undergoing coronary CT angiography (CCTA). The following features are included in the new sy...

Basilar thrombolysis in cerebral infarction (bTICI) scale: Proposal and preliminary validation of a basilar reperfusion score based on digital subtraction angiography to evaluate the efficacy of mechanical thrombectomy in acute basilar artery occlusion.

OBJECTIVES: Basilar artery occlusion (BAO) accounts for 10% of all ischemic strokes due to largevessel occlusion (LVO) and is associated with highest mortality and disability rate. The aim ofthis stud...

Adrenal venous sampling: Indications and technical challenges.

Adrenal venous catheterisation is a procedure used in the aetiological diagnosis of primary aldosteronism (PA). Its purpose is to measure aldosterone and cortisol levels in blood samples obtained from...

Overexpression of Circular RNA circTTN Promotes Ferroptosis in Sepsis-Induced Cardiomyopathy.

Sepsis-induced cardiomyopathy (SCM) is one of the common complications caused by sepsis. Despite the higher mortality rate associated with SCM, the pathogenesis of SCM is poorly understood. The study ...

Focused ultrasound-induced blood-brain barrier modulation for drug delivery in recurrent glioblastoma: A systematic review.

Background and objectives Glioblastoma is the most aggressive primary adult central nervous system of malignancy, with a median overall survival of 12-18 months. Recurrence is almost inevitable and ca...

Perfluorooctane Sulfonate Exposure and Peripheral Artery Disease: Mendelian Randomization and Integrative Multi-Omics Systems Toxicology With Machine Learning.

Epidemiological and experimental studies have linked legacy and emerging PFAS to adverse cardiovascular outcomes, yet most evidence remains observational and is susceptible to confounding, measurement...

Inhibition of SGLT2 reduces blood pressure in the early phase of salt-sensitive hypertension in male Dahl-SS rats independently of changes in renal inflammation.

Salt-sensitive hypertension is a progressive condition characterized by albuminuria, renal injury, and inflammation. The initiating mechanisms remain unclear. We hypothesized that early in salt-sensit...