Mechanisms and integrative machine learning approaches to blood-brain barrier biomarker profiling for personalized ischemic stroke management.
Ischemic stroke remains a leading cause of death and disability worldwide, with blood-brain barrier (BBB) disruption playing a central role in vasogenic edema, neuroinflammation, hemorrhagic transform...
Evaluation of High-Density Lipoprotein Capacity to Acquire Free Cholesterol From Triglyceride-Rich Lipoproteins During Reverse Remnant-Cholesterol Transport in Familial Hypercholesterolemia.
INTRODUCTION: High-density lipoprotein (HDL) serves as a key protective factor against elevated low-density lipoprotein cholesterol (LDL-C) levels in patients with familial hypercholesterolemia (FH). ...
The Ross Operation in Children-What Is the Long-Term Fate of the Autograft?
OBJECTIVES: The Ross operation achieves excellent outcomes in children and adolescents, but the influence of age at surgery and underlying pathology on long-term results remains uncertain. Evidence on...
Diabetic Retinopathy Severity and Heart Failure Outcomes in Type 2 Diabetes Mellitus.
BACKGROUND: The precise link between diabetic retinopathy and incident heart failure remains unclear, largely limited by a lack of echocardiographic data. This study evaluated how the clinical severit...
Association of Frailty and Its Trajectories With the Risk of Cardiovascular-Kidney-Metabolic Syndrome Progression: A Longitudinal Cohort Study.
AIMS: Frailty reflects a decline in physiological reserve and has been widely recognized as an important risk factor for cardiovascular disease (CVD). However, the relationships between frailty and th...
Valsartan Reduces Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferritinophagy-Mediated Ferroptosis.
Revascularisation is the key therapeutic strategy for acute myocardial infarction (AMI). However, the opening of the 'culprit artery' is accompanied by myocardial ischemia-reperfusion injury (IRI), pa...
Beyond Viral Control: Tenofovir's Hidden Impact on Blood-Brain Barrier Endothelial Cells.
UNLABELLED: The blood-brain barrier (BBB) is a dynamic endothelial interface that protects the brain from harmful agents while regulating molecular exchange. Human immunodeficiency virus (HIV) comprom...
Identification of PRKCB, NLRC4, and TNFSF10 as Key Regulators of the Lipid Metabolism-Autophagy Network in Atherosclerosis.
BACKGROUND: The occurrence and development of atherosclerosis (AS) are closely related to disorders of lipid metabolism and dysfunction of autophagy. However, the key regulatory genes and immune micro...
Intracardiac Echocardiography Versus Transesophageal Echocardiography for Guidance of Atrial Fibrillation Ablation: A Systematic Review and Meta-Analysis of Procedural Safety and Efficacy.
PURPOSE: Transesophageal echocardiography (TEE) is the standard periprocedural imaging modality for atrial fibrillation (AF) catheter ablation but carries the burden of esophageal instrumentation, fre...
Nailfold Videocapillaroscopy in Pediatric Rheumatology: Established Roles, Emerging Applications, and Future Perspectives.
Nailfold videocapillaroscopy (NVC) provides direct, non-invasive access to the peripheral microcirculation and has become a central tool in adult rheumatology. Its primary clinical value lies in the e...
From Cutaneous Necrosis to Septic Shock: An ICU Case of Pancreatico portal Fistula Complicating Necrotizing Acute Pancreatitis.
BACKGROUND: Pancreaticoportal fistula is an exceptionally rare and potentially fatal vascular complication of necrotizing pancreatitis. Its clinical presentation can be atypical, leading to delayed di...
How to apply the DAZE technique: structured approach to fetal cardiac image optimization.
Accurate prenatal detection of congenital heart disease continues to be challenging in routine obstetric practice, despite established screening guidelines. Missed diagnoses are frequently associated ...
Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function.
PURPOSE: To study the biological effects of aflibercept and faricimab on vascular endothelial growth factor (VEGF)-A165-induced vascular permeability in an in vitro head-to-head comparison using human...
Explicit Inclusion of Diabetes Mellitus Without Retinopathy Within Diabetic Retinopathy Prediction.
PURPOSE: The purpose of this study was to evaluate whether explicitly modeling diabetes mellitus (DM) without diabetic retinopathy (DR) as its own stage enables deep learning (DL) to detect early reti...
Totally implantable venous access port implantation in a breast cancer patient with situs inversus totalis: A case report.
Situs inversus totalis, a rare congenital condition characterized by complete mirror-image transposition of the thoracic and abdominal organs, has not previously been reported in patients with breast ...
Perfusion Interval and Myocardial Injury in Minimally Invasive Mitral Valve Surgery: The Modifying Role of Aortic Cross-Clamp Duration.
OBJECTIVES: To assess how perfusion interval relates to myocardial injury and whether this is modified by aortic cross-clamp (ACC) duration in minimally invasive mitral valve surgery. METHODS: We retr...
[Cardiogenetics in clinical practice : challenges, indications, and perspectives].
Cardiogenetics plays an increasingly important role in managing cardiovascular diseases, owing to the major impact of genetic data on diagnosis, risk stratification, therapeutic decision-making, and f...
Effects of adrenal ablation on blood pressure and target organ damage in deoxycorticosterone acetate-salt hypertensive rats.
BackgroundPrimary aldosteronism is a common and underdiagnosed form of secondary hypertension. However, preclinical investigations of adrenal ablation as a potential therapeutic approach for primary a...
PGC-1α-Nrf2 Signaling Imbalance Mediates Doxorubicin-Induced Mitochondrial Dysfunction and Cardiac Injury.
Doxorubicin (DOX)-induced cardiotoxicity is characterized by mitochondrial dysfunction and oxidative stress; however, the mechanistic interplay between mitochondrial metabolic regulation and antioxida...
Drinking water salinity and blood pressure in coastal Bangladesh: follow-up of a population-based cohort in a climate-vulnerable region.
OBJECTIVES: To investigate the association between drinking-water sodium concentration and blood pressure among non-pregnant women living in a high-salinity, climate-vulnerable coastal region of Bangl...