The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large-Artery Atherosclerotic Acute Ischemic Stroke.
BACKGROUND: GNB3 C825T polymorphism affects G protein-coupled receptor signaling, influencing platelet function, inflammation, and cardiovascular risk. This study aimed to investigate the unknown effe...
SREBP gene polymorphisms and ambulatory blood pressure parameters in Chinese adolescents: a cross-sectional study.
UNLABELLED: The purpose of this study was to investigate the association between SREBP gene polymorphisms and ambulatory blood pressure phenotypes. In the present study, 514 college students from a un...
Identifying Contextual Barriers and Potential Solutions to Improving Hypertension Management in Rural Communities in the United States: Qualitative Study From 2 North Carolina Counties.
BACKGROUND: Blood pressure-related deaths from cardiovascular disease are higher in rural than in urban areas in the Unites States, especially in southeastern states. However, the barriers and potenti...
Three-Year Durability of Radiofrequency Renal Denervation: SPYRAL HTN-ON MED.
BACKGROUND: The SPYRAL HTN-ON MED (Global Clinical Study of Renal Denervation With the Symplicity Spyral Multielectrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard ...
Multimodal Machine Learning Integrating Clinical and Proteomic Data for Early Prediction of Hypertensive Complications: A UKB Longitudinal Study.
BACKGROUND: Hypertension is a leading risk factor for cardiovascular, cerebrovascular, and renal diseases, significantly worsening prognosis and quality of life. We aimed to develop and validate multi...
Machine Learning-Driven Prediction of Coronary Artery Disease Risk Based on UK Biobank Plasma Proteomics.
BACKGROUND: Coronary artery disease (CAD) is a leading global cause of mortality, yet the predictive accuracy of conventional risk models is limited. Here, we integrate conventional risk factors, poly...
Subclass-Specific Impact of β(1)-Adrenergic Receptor Autoantibodies and Phenotype-Specific Interaction With β-Blockers in a Contemporary Population With Heart Failure.
BACKGROUND: The clinical significance of β1AR-AAb (β1-adrenergic receptor autoantibody) subclasses, particularly IgG3 (immunoglobulin G subclass 3), in contemporary populations with HF (heart failure)...
Comprehensive Prestroke Risk Factor Control and Functional Outcomes After Acute Ischemic Stroke.
BACKGROUND: Whether comprehensive prestroke risk factor (RF) management-defined by the extent to which existing major RFs meet prespecified treatment and biomarker criteria-is associated with 3-month ...
Menopausal Age, Number of Live Births, and Risk of Atrial Fibrillation: The Cardiovascular Health Study.
BACKGROUND: Female reproductive factors including menopausal age and number of live births have been associated with cardiovascular disease risk, but their role in atrial fibrillation (AF) is underexp...
Left Atrial Appendage Electrical Isolation Reduces Residual Patency After Device Closure in Patients With Persistent Atrial Fibrillation.
BACKGROUND: Left atrial appendage (LAA) patency after catheter ablation and LAA closure (LAAC) is a key determinant of postprocedure stroke. The effect of LAA electrical isolation (LAAEI) on LAA paten...
Impact of Diabetes on the Efficacy of Low-Voltage Area Ablation for Persistent Atrial Fibrillation: A Subanalysis of the SUPPRESS-AF Trial.
BACKGROUND: The potential value of low-voltage area (LVA) ablation for persistent atrial fibrillation (AF) has been suggested. However, its efficacy determinants remain unclear. We investigated the im...
Hippocampal cytopathology orchestrates post-septic cognitive dysfunction.
Cognitive dysfunction induced by sepsis is a common clinical disease. The hippocampus is one of the brain regions most vulnerable to sepsis. However, the correlations between sepsis-mediated neural ce...
10-Year Randomized Outcomes of Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Aortic Stenosis.
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an established alternative to surgical aortic valve replacement for symptomatic severe aortic stenosis, but long-term, comparative clinical...
10-Year Outcomes of SAPIEN 3 Transcatheter Aortic Valve Replacement or Surgery in Intermediate-Risk Patients.
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an alternative to surgical aortic valve replacement for patients with symptomatic severe aortic stenosis. However, long-term outcomes data ...
Model-informed dose optimization of carvedilol and nebivolol in cirrhotic patients: a pilot randomized clinical study.
Liver cirrhosis causes physiological and pharmacokinetic alterations that complicate antihypertensive therapy, in the presence of portal and arterial hypertension. This study evaluated the efficacy an...
A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.
Thin-strand pericytes cover the deepest reaches of the brain's capillary network, and their fine processes are intimately associated with adjacent endothelial cells (ECs). Recent work has revealed tha...
Percutaneous mechanical aspiration has emerged as a novel, catheter-based strategy for the management of right-sided infective endocarditis, particularly in patients with a suboptimal response to anti...
Heart failure is an increasingly common comorbidity among people with HIV infection, complicating care and heightening the vulnerability of this population to social adversity (SA). However, the impac...
Individuals of African ancestry are underrepresented in genetic studies, contributing to disproportionately higher rates of variants of uncertain significance (VUS) and fewer actionable results in gen...
Familial hypercholesterolemia (FH) is an inherited disorder characterized by lifelong elevated LDL-C (low-density lipoprotein cholesterol) and increased risk for premature myocardial infarction. FH re...