Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation.
BACKGROUND: The evolving landscape of mitral valve transcatheter edge-to-edge repair (M-TEER) for mitral regurgitation (MR) has seen continuous advancements, driving improvements in therapeutic effica...
Quantification of mitral regurgitation: from traditional methods to artificial intelligence.
Mitral regurgitation (MR) is a common valvular disorder and associated with adverse outcomes. Echocardiography is the primary imaging modality for MR assessment; however, standard methods rely on geom...
Zebrafish dspb-/- mutant as a model for non-dilated left ventricular cardiomyopathy: exploring cardiac dysfunction and exercise modulation.
Truncating variants in the DSP gene are associated with non-dilated left ventricular cardiomyopathy (ND-LVC), characterized by impaired ventricular function without dilation. The influence of physical...
Primary Prevention of Dyslipidemia: 10 Practice-Changing Takeaways from the 2026 ACC/AHA Multisociety Guideline.
PURPOSE OF REVIEW: Dyslipidemia remains a common and treatable risk factor for atherosclerotic cardiovascular disease (ASCVD) in the United States (US) and worldwide. In 2026, the American College of ...
Development and application of a quantitative physicochemical model of P-gp substrate specificity.
Active transport of small molecules out of the cells mediated by efflux pumps of the ABC superfamily is an important biochemical phenomenon precluding delivery of drug molecules to the site of action,...
Atypical variants of the cerebral arterial circle beyond the Lazorthes classification: a retrospective morphologic and neuroradiologic study.
PURPOSE: To characterize atypical variants of the cerebral arterial circle that fall outside the Lazorthes classification and to interpret them in a contemporary neuroradiologic framework. METHODS: Th...
Anatomical characteristics and coordinate-based mapping of neurovascular structures within the ankle flexor retinaculum in Vietnamese cadavers.
PURPOSE: This study aimed to characterize the anatomical features of the ankle flexor retinaculum and to provide a coordinate-based anatomical data on tibial nerve and posterior tibial artery branchin...
Chronotherapy to reinforce circadian rhythms improves poststroke outcomes and glymphatic function in mice.
Stroke remains a leading cause of morbidity and mortality worldwide, with few effective interventions to promote recovery. Targeting circadian timing and glymphatic function may represent viable thera...
Timing of Coffee Intake Modifies Mortality Risk in Cardiovascular-Kidney-Metabolic Syndrome: A Cohort and Experimental Study.
The association between the timing of coffee consumption and mortality risk among individuals with cardiovascular-kidney-metabolic (CKM) syndrome remains unclear. This study aims to identify patterns ...
Disease-Associated Remodeling of m6A RNA Methylation in Human Interstitial Cells From Fibro-Calcific Aortic Valves.
Calcific aortic valve disease is common in older adults and a major cause of aortic stenosis. Despite its clinical impact, there are still no effective drugs that slow disease progression, and treatme...
Impella 5.5-Assisted Coronary Arterial Bypass Graft in a Patient With Severe Reduced Left Ventricular Function: A Case Report.
Coronary artery disease is the most common type of heart disease. Revascularization with coronary artery bypass grafting can improve survival in patients with severe coronary artery disease and reduce...
FTO Regulates Autophagy and Energy Metabolism in Sepsis-Induced Cardiomyopathy: Insights From Integrated Transcriptome and Proteome Analysis.
Sepsis-induced cardiomyopathy (SCM) is a severe complication of sepsis, characterized by profound cardiac dysfunction and high mortality, but its molecular mechanisms remain poorly defined. RNA epigen...
Artificial Intelligence-Driven Fractional Flow Reserve Assessment: Technical Foundations, Clinical Insights, and Future Directions.
Coronary artery disease (CAD) remains a leading cause of global morbidity and mortality. Accurate diagnosis of ischemia-causing coronary stenoses is essential for guiding revascularization and improvi...
Hydroxychloroquine-associated cardiomyopathy with nondiagnostic noninvasive evaluation: diagnostic value of endomyocardial biopsy in a case-based review.
Hydroxychloroquine (HCQ) is a cornerstone in treating autoimmune diseases and is generally well-tolerated. Cardiotoxicity is a rare but serious adverse effect of prolonged HCQ therapy. The progression...
Clinical Case of Inferior Vena Cava Leiomyoma in a Patient with Thrombocytopenia.
Primary leiomyomas of the vascular system, particularly of the inferior vena cava (IVC), are extremely rare benign vascular tumors, which, due to their extraluminal growth, can mimic tumors of the adj...
[Initial disorders of pulmonary hemodynamics in patients with systemic sclerosis: the relevance of the new hemodynamic definition of pulmonary arterial hypertension].
AIM: To investigated the impact of the new hemodynamic definition of pulmonary arterial hypertension (PAH) as proposed by the 6th PH World Symposium on the phenotypes, outcome and survival in patients...
[Rheumatoid nodule in the myocardium as part of the chain in a clinical detective. Case report].
The article describes a clinical case of a patient, at first glance healthy from the cardiovascular side, whose only complaint was ventricular extrasystole during exacerbations of arthritis. A typical...
Troponin T, Left Ventricular Ejection Fraction, and Tricuspid Regurgitation Velocity for Biomarker- and Echocardiography-Based Risk Stratification in Critically Ill Patients with Heart Failure.
Troponin T is a molecular marker of cardiomyocyte injury, whereas left ventricular ejection fraction (LVEF) and tricuspid regurgitation velocity (TRV) reflect downstream ventricular and cardiopulmonar...
Low-Level Domoic Acid Exposure Induces Age-like Cardiomyopathy in Young Adult and Aged Mice.
Domoic acid (DA) is a well-known seafood toxin produced by some species of marine phytoplankton in the genus Pseudo-nitzschia during harmful algal blooms (HABs). Acute toxic exposures induce overt cli...
Distinct From the Adult Paradigm: Re-Evaluate the Pathophysiological and Therapeutic Framework in Children and Adolescent Hyperlipidaemia.
PURPOSE OF REVIEW: This review aims to summarize current advances in children and adolescent hyperlipidemia, and re-evaluate the unique epidemiology, genetic and environmental causes, and pathophysiol...