Cell size control emerges from the vein-dependent coordinated divisions of distinct cell groups in Drosophila wing.
During morphogenesis, cell divisions are precisely regulated in space and time. The biological objectives achieved by such regulation are not fully understood. Here, by applying a newly developed line...
The people behind the papers - Zhainib Amir-Ugokwe and Kristy Red-Horse.
During human vascular development and regeneration, arterial cells can be made from both mesodermal and venous cells. Whilst in vitro human models of mesodermal to arterial conversion have been establ...
SGLT2 Inhibitors in Hypertrophic Cardiomyopathy: Emerging Evidence and Putative Mechanisms.
Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disorder and a major cause of heart failure (HF) and sudden cardiac death. Although sarcomeric gene mutations initiate the dis...
Absence of GDF15 Aggravates Pressure Overload-Induced Cardiac Remodelling in Mice Hallmarked by Perivascular Fibrosis and Signs of Endothelial-to-Mesenchymal Transition.
Growth differentiation factor 15 (GDF15) levels are associated with increased mortality and rehospitalisation in heart failure (HF) patients. Whether GDF15 is causally involved in the pathobiology of ...
[Research progress of lymphaticovenous anastomosis in treatment of severe extremity trauma].
OBJECTIVE: To review the research progress of lymphaticovenous anastomosis (LVA) in the treatment of severe extremity trauma and prospect its clinical application prospects. METHODS: Based on the exis...
Coronary Artery Calcium Score - Practical Considerations for Underwriting.
This brief practical review explores the fundamentals of coronary artery calcium score testing, its role in cardiovascular risk stratification, and how it can empower underwriting CV risks with greate...
[Advances in the molecular genetics of nuclear gene mutations causing pediatric mitochondrial cardiomyopathy].
Mitochondrial cardiomyopathy (MCM) is a heterogeneous group of disorders characterized by abnormal myocardial structure and/or function caused by defects in genes encoding the oxidative phosphorylatio...
[Early warning indicators and prognosis in children with fulminant myocarditis treated with extracorporeal membrane oxygenation].
OBJECTIVES: To explore early warning indicators for extracorporeal membrane oxygenation (ECMO) in children with fulminant myocarditis (FM) and their association with prognosis. METHODS: Clinical data ...
[Effect of miR-155-5p regulating the TLR4/MAPK/NF-κB pathway on inflammatory response, coronary artery lesion and immune function in mice with Kawasaki disease].
OBJECTIVES: To investigate the effect of miR-155-5p regulation of the TLR4/MAPK/NF-κB pathway on inflammatory response, coronary artery lesion, and immune function in mice with Kawasaki disease (KD). ...
Determinants of systolic murmurs without significant valvular heart disease in an unselected Norwegian adult population: the Tromsø Study.
BACKGROUND: Systolic murmurs are common in adults without significant valvular heart disease (VHD) and are more prevalent in women than in men, but the determinants of murmur audibility remain unclear...
Cross-interference of hemolysis, icterus and lipemia: A study with real patient samples.
INTRODUCTION: Hemolysis, icterus, and lipemia (HIL) are frequent preanalytical interferences, leading to erroneous results or sample rejection. While individual effects of these indices have been stud...
Circulating nitric oxide pathway metabolites in heart failure with preserved ejection fraction: a sex-stratified cross-sectional analysis.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is more prevalent in women, who often present with earlier onset and greater severity of vascular and endothelial dysfunction. Nitric...
Sex Differences in the Effect of Long-Term Blood Pressure Trajectories and Variability on the Atrial Fibrillation Risk in a Korean Cohort.
BACKGROUND: Long-term blood pressure (BP) patterns and variability may influence atrial fibrillation (AF) risk. However, whether these associations differ according to sex is unclear. METHODS: We anal...
Myocardial fibrosis and viability: the role of imaging and biomarkers in patients with chronic total occlusion on coronary angiography.
In patients with chronic total occlusion on coronary angiography, myocardial viability assessment is an essential tool in guiding treatment decisions, especially revascularization. Current non-invasiv...
Effect of Ashwagandha (Withania somnifera) on cardiac aquaporins in adolescent rats under a chronic unpredictable mild stress model.
Adolescent depression is a prevalent and serious mental health issue that can negatively impact multiple organ systems, including the cardiovascular system. This study investigates the effects of chro...
Comparison of endovascular procedures of the lower extremities and iliac arteries with and without navigation assistance Vascular Navigation PAD: study protocol for a prospective multicenter randomized clinical trial.
BACKGROUND: Endovascular procedures using a mobile C-arm are commonly performed in patients with peripheral artery disease. During these procedures, digital subtraction angiography (DSA) requires intr...
Novel use of arm ergometry cardiopulmonary exercise testing for non-elective patients with chronic limb-threatening ischaemia: a feasibility trial.
OBJECTIVES: To evaluate the feasibility, safety and acceptability of arm crank ergometry cardiopulmonary exercise testing (CPETarm) in patients with chronic limb threatening ischaemia (CLTI). DESIGN: ...
Concurrent thyroid ima artery, high-riding brachiocephalic trunk, and supreme intercostal artery in thoracic vertebral artery configuration: a computed tomography angiography case report.
PURPOSE: To report a cluster of five concurrent cervical vascular variants identified on computed tomography angiography (CTA), including a thyroid ima artery (TIA) from a high-riding brachiocephalic ...
Smart Technology, Fragile Hearts: Navigating AI's Challenges and Limitations in Heart Failure Management.
PURPOSE OF REVIEW: This review synthesizes recent progress in applications of artificial intelligence to heart failure care, including phenotyping, risk stratification, imaging interpretation, and poi...
Outcomes of intraprocedural haemodynamic changes in patients undergoing mitral transcatheter edge-to-edge repair.
BACKGROUND: While the mean left atrial pressure (mLAP) reduction during mitral transcatheter edge-to-edge repair (M-TEER) has been suggested as a potential prognostic marker, comprehensive evidence fr...