Left Atrial Volume and Strain by Two-Dimensional Versus Three-Dimensional Echocardiography in Healthy Subjects: Reference Values are Not Interchangeable.

BACKGROUND: Little is known about the differences in left atrial (LA) volume and strain assessed with two-dimensional (2DE) and three-dimensional echocardiography(3DE). Therefore, this study aimed to ...

Insights on Endothelial Injury.

Endothelial barrier dysfunction is the hallmark of severe disease, including sepsis and lung injury. The present study summarizes recent advances in the development of pharmacotherapies to counteract ...

Comparing Outcomes of Heartmate 3 and Heart Transplantation in Older Children With Dilated Cardiomyopathy-Can Transplantation be Delayed or Avoided?

BACKGROUND: Children with end-stage dilated cardiomyopathy (DCM) usually undergo heart transplantation or a short-term bridge with a ventricular assist device. Heartmate 3 (HM3) may represent an appea...

Emerging biomedical and pharmaceutical strategies for the treatment of atherosclerosis: from conventional lipid-lowering therapy to nanomedicine.

Atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and ischemic stroke, is a leading cause of death and disability worldwide and is expected to rise further by 2030. Once ...

Efficacy and Safety of Baxdrostat for Hypertension: A Systematic Review and Meta-Analysis of Three Phase 2/3 Randomized Controlled Trials.

BACKGROUND: Baxdrostat is a selective aldosterone synthase (CYP11B2) inhibitor for treatment-resistant and uncontrolled hypertension, evaluated in phase 2/3 RCTs. OBJECTIVES: To estimate pooled placeb...

Extending the PREVENT Equations with Cardiac MRI: Prediction of 10-year Heart Failure Risk.

Background Accurate prediction of heart failure (HF) risk is crucial for early intervention and prevention. Traditional models rely on clinical risk factors, whereas cardiac MRI parameters may offer a...

A Comparative Analysis of the Effects of Cardioversion and Ablation on Anxiety, Sleep, and Quality of Life in Patients Diagnosed With Atrial Fibrillation.

BACKGROUND AND AIMS: This study aims to evaluate changes in quality of life, anxiety levels, and sleep quality before and after elective electrical cardioversion or ablation in patients diagnosed with...

Elevated FTX Expression in Polycystic Ovary Syndrome: Correlations With Insulin Resistance, Dyslipidemia, and Diagnostic Potential.

BACKGROUND: This study aims to investigate the expression changes of FTX (long noncoding RNA) in polycystic ovary syndrome (PCOS) and its relationship with insulin resistance and lipid metabolism, the...

A pilot qualitative study of patient understanding and perceptions of genetic counselors and cascade testing in the context of transthyretin cardiac amyloidosis.

Genetics-informed care is becoming increasingly important in the management of cardiomyopathy (CM). Despite current guidelines recommending genetic testing and counselors, these services are vastly un...

Effect of Health Literacy on use of a Virtual Coach to Promote Home Blood Pressure Monitoring.

Health literacy and hypertension control are more limited in rural U.S. residents relative to metropolitan counterparts. Contemporary hypertension guidelines advocate for health education and home blo...

Alveolar Capillary Dysplasia With Misaligned Pulmonary Veins (ACDMPV): Description of Two Cases and Literature Review.

INTRODUCTION: Alveolar capillary dysplasia with misaligned pulmonary veins (ACDMPV) is one of the major causes of neonatal interstitial lung disease, causing persistent pulmonary hypertension (PH) of ...

Impact of Chronic Kidney Disease Severity on Clinical Outcomes After Drug-Eluting Stent Implantation: A Propensity Score-Matched Analysis.

BACKGROUND: Chronic kidney disease (CKD) is prevalent among patients undergoing percutaneous coronary intervention (PCI) and associated with adverse cardiovascular outcomes. This study evaluated the a...

Strategic decision-making for redo cardiac surgical patients with biventricular heart failure - description of a surgical technique.

BACKGROUND: Left ventricular assist devices (LVADs) play a critical role in managing end-stage heart failure (HF), serving as a bridge to transplantation (BTT) or as destination therapy (DT). Patients...

Dynamic needle tip positioning may improve first-attempt success rate in short-axis radial artery cannulation: A systematic review and meta-analysis of randomized trials.

BackgroundUltrasound-guided radial artery cannulation is routinely performed; however, the optimal imaging approach remains debated. The short-axis out-of-plane approach facilitates vessel centering; ...

Inflammatory Neovascularization and Vascular Remodeling Associated With Carotid Plaque Destabilization.

AIMS: Inflammatory responses promote pathological neovascularization and vascular remodeling in carotid plaques, contributing to plaque destabilization. This study aims to clarify specific cellular su...

Learning from a pitfall: Atrial septostomy in LV failure under VA-ECMO for pulmonary hypertension.

BACKGROUND: Atrial septostomy has been successfully used in patients with pulmonary hypertension and in those supported with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) complicated by ...

Unripe Musa paradisiaca Peel Extract Improves Dyslipidemia and Cardiac Dysfunction in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Rats.

Plant-derived foods are rich in bioactive compounds with notable therapeutic potential. Plantain (Musa paradisiaca L.) is widely cultivated and traditionally used in managing inflammation and diabetes...

Blood Flow Restriction Training Reduces Hemodynamic Load and Improves Cardiovascular Biomarkers in Runners with Exercise-Induced Hypertension.

Exercise-induced hypertension (EIH) is associated with elevated risks of arrhythmia, coronary artery disease, arterial stiffness, and sudden cardiac death. Blood flow restriction (BFR) training has be...

Antihypertensive Potential of Selected Edible Sources From the Northeastern Highlands of Puebla Mexico and Their Main Phenolic Compounds.

Herein, we report on the anti-human angiotensin converting enzyme (ACE) properties of 31 hydroethanolic extracts from the edible organs of 30 edible plants consumed in the Northeastern Highlands of Pu...

Effect of Body Mass Index on the Efficacy and Safety of Esaxerenone Versus Trichlormethiazide for the Treatment of Japanese Patients with Uncontrolled Essential Hypertension: A Subanalysis of the Excite-HT Study.

This prespecified, exploratory, body mass index (BMI)-stratified analysis of the randomized, open-label EXCITE-HT study examined whether esaxerenone elicits a blood pressure (BP)-lowering effect simil...