Plasma soluble triggering receptor expressed on myeloid cells 2 levels and clinical outcomes in acute decompensated heart failure: A retrospective cohort study.
ObjectiveEmerging evidence suggests a potential role for soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cardiovascular pathophysiology. However, plasma sTREM2 levels in patients ...
Saikosaponin D Alleviates Atherosclerosis by Regulating Autophagy and Senescence of VSMCs via Inhibiting EPHB2.
BACKGROUND: Atherosclerosis (AS) is a major cause of cardiovascular diseases, with OX-LDL-induced VSMC dysfunction being a critical pathogenic driver of AS development. Saikosaponin D (SSD), a bioacti...
Selective titin cleavage disrupts cardiac mechanical homeostasis to drive heart failure and fibrosis.
Titin, the largest human protein, forms the elastic sarcomeric backbone, providing passive stiffness and length-dependent activation in cardiomyocytes. Whereas titin mutations cause inherited cardiomy...
A Review of Dietary and Nutritional Supplements Used to Promote Cardiovascular Health.
Cardiovascular disease is frequently diagnosed in birds that are presented to veterinary hospitals, and atherosclerosis is a common cardiovascular condition identified in postmortem evaluations of pet...
Pacemaker Therapy: Indications and Recommendations.
Pacemakers are implantable cardiac devices used in the treatment of bradycardia and heart failure. They monitor electrical signals in the heart and deliver electrical stimuli to cause contraction in t...
Influence of Cooling Agents on the Arrhythmogenic and Autonomic Effects of Electronic Cigarettes in an in vivo Model.
BACKGROUND: Despite the growing popularity of electronic cigarettes, evidence is mounting that vaping induces autonomic nervous system imbalance, cardiac arrhythmia, and potentially even cardiac arres...
Hybrid Cardiac (68)Ga-FAPI-4 PET/MRI in Dilated Cardiomyopathy: A Feasibility and Pilot Study.
Background Cardiac gallium 68-labeled fibroblast activation protein inhibitor (FAPI)-4 (68Ga-FAPI-4) PET/MRI allows simultaneous assessment of cardiac tissue characteristics, function, and molecular r...
[Lean and Value-Based Healthcare methods to support the chronic heart failure care model.].
INTRODUCTION: Heart Failure (HF) represents a critical challenge for the National Health Service (SSN) in terms of mortality and costs, often fueled by fragmented management between hospital and commu...
Next-generation intranasal delivery nano-platforms for targeted brain therapy of Alzheimer's disease.
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that poses a growing global health burden. Effective drug delivery to the brain is largely constrained by the selecti...
Biventricular Coupling: Physiological Function, Anatomical Remodeling and Advances in Ultrasound Imaging.
The cardiovascular system is among the earliest functional systems in fetal development, playing a central role in maintaining circulation and ensuring oxygen and nutrient delivery. The fetal heart un...
The Association Between Plasma Atherogenic Index Control Level and the Onset of Hypertension in Chinese Children and Adolescents.
The association of atherogenic index of plasma (AIP) control level with hypertension onset in children was still unclear. This study aimed to investigate the association between AIP control levels and...
Diastolic Morning Surge Improves Risk Stratification for Subclinical Left Ventricular Diastolic Dysfunction in Ambulatory-Defined Isolated Diastolic Hypertension.
Isolated diastolic hypertension (IDH) is frequently considered a lower-risk phenotype due to preserved systolic pressure; however, sustained ambulatory diastolic load may promote early myocardial remo...
Empagliflozin and renal histological changes in an experimental model of heart failure in male rats.
Renal dysfunction in heart failure (HF) involves congestion-associated injury, tubular damage, and inflammatory remodeling. Although SGLT2 inhibitors improve renal outcomes in HF, associated renal str...
Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.
INTRODUCTION: Atrial fibrillation (AF) is the most common arrhythmia in the elderly, and is associated with an increased risk of cardiovascular events (CVE). Hypoalbuminemia is an independent predicto...
The illusory correlation between geometrical similarity and physician satisfaction in heart auto-segmentation revealed by a physician-blind test.
BACKGROUND: Auto-segmentation tools are essential in adaptive radiation therapy (ART). While evaluation typically relies on geometric metrics like Dice similarity coefficient (DSC), high scores do not...
A new era in atherothrombosis.
Atherothrombosis is a complex vascular disorder in which a thrombus forms on a vascular lesion, typically following the disruption and/or erosion of an atherosclerotic plaque. Atherothrombosis is the ...
Can markers predict plaque vulnerability?
The concept of "vulnerable plaque" (VP) has been evolving since its introduction as an atherosclerotic plaque prone to cause cardiovascular events, such as myocardial infarction and stroke. Once defin...
Hematopoietic somatic mutations in atherosclerotic cardiovascular disease.
Age-related somatic mosaicism in the hematopoietic system is increasingly recognized as a risk factor for atherosclerotic cardiovascular disease. The most prominent example is clonal hematopoiesis of ...
The secretory PCSK family in cardiovascular disease and beyond.
It took >20 years to discover the family of proteases implicated in the activation and/or regulation of the activity of secretory proteins, including polypeptide hormones, growth factors and receptors...
Standard modifiable cardiovascular risk factors and acute coronary syndrome free survival.
BACKGROUND AND AIMS: Recent studies suggest that patients without standard modifiable cardiovascular risk factors (SMuRFs), hypertension, hypercholesterolemia, diabetes, or smoking, may experience hig...