Relationship Between Social Frailty and Sarcopenia and Its Impact on Long-Term Prognosis in Older Patients With Stage B Heart Failure: A PAPRIKA-HF Registry Subanalysis.

AIM: To investigate the association between social frailty and sarcopenia and their combined effect on clinical outcomes in outpatients with stage B heart failure (HF). METHODS: This post hoc analysis...

Long-term prognostic impact of optical coherence tomography detected plaque rupture in nonculprit coronary segments.

BACKGROUND AND AIMS: Atherosclerotic plaque rupture is largely acknowledged as the main mechanism of acute coronary syndrome. However, the prognostic significance of plaque rupture detected in nonculp...

Exercise as medicine: Improving cardiovascular health through physical activity.

Cardiovascular diseases remain the leading cause of global mortality, and growing evidence shows that regular exercise is one of the most effective non-pharmacological strategies to prevent and modify...

Sedentary Behavior, Physical Activity, and Hypertension: Genetic Liability and the Role of Metabolic Factors.

BACKGROUND: Whether sedentary behavior and physical activity causally influence hypertension remains uncertain. We used Mendelian randomization (MR) to examine whether genetically predicted domain-spe...

Uric Acid and Uric Acid Index in Predicting Coronary Artery Disease, Cerebrovascular Events, and Mortality: A Sex-Stratified Cohort Study.

AIM: Recent studies have highlighted the predictive value of serum uric acid (SUA), fasting blood glucose (FBG), and triglycerides (TG) for cardiovascular diseases (CVDs). A newly developed uric acid ...

Association Between Comprehensive Health Assessment and Cardiac Mortality and All-Cause Mortality in Patients With Coronary Heart Disease.

BACKGROUND: Coronary heart disease (CHD) confers a substantial global burden, and comprehensive health assessment is critical for secondary prevention. However, the independent and joint associations ...

[Screening for frailty in heart failure patients under remote monitoring and coordination of the care pathway by the registered nurse].

Frailty syndrome is frequently associated with heart failure (HF). It is a progressive condition associated with a poor prognosis but is potentially reversible. The study presented here aims to evalua...

[Implementation of an ETP program for patients with heart failure and reduced ejection fraction in cardiovascular rehabilitation].

This article describes the implementation of a program that incorporates therapeutic education into the care of patients with heart failure and reduced left ventricular ejection fraction who are admit...

Health Status Changes and Long-Term Clinical Outcomes in Patients With Atrial Fibrillation.

IMPORTANCE: Improving health status, including symptoms and quality of life, is a key goal in the management of atrial fibrillation (AF). However, whether improvements in patient-reported health statu...

Early Outcomes of Real-World Aortic Valve Replacement With RESILIA Tissue in the Chinese Population.

BACKGROUND: Aortic valve replacement (AVR) with the INSPIRIS RESILIA aortic valve (Edwards Lifesciences, Irvine, CA) has established durability and promising outcomes. However, real-world safety and f...

Bleeding-related quality of life in older adults: Psychometric evaluation of the HEmorrhage Life Impact indeX (HELIX).

BACKGROUND: Older adults treated with anticoagulants for atrial fibrillation (AF) or venous thromboembolism (VTE) face heightened bleeding risk, which can affect physical, emotional and social wellbei...

Patient-Specific In Silico Prediction of Outcomes of Partial Continuous-Flow LVAD Treatment in Peripartum Cardiomyopathy.

Patients with severe peripartum cardiomyopathy (PPCM) often receive mechanical circulatory support with good outcomes. However, mechanisms underlying the functional improvements are poorly understood ...

FTO-Catalysed Demethylation of LUR1 mRNA Suppresses Macrophage Lipid Accumulation and Aortic Atherosclerosis.

Lipid deposition and foam cell formation drive atherogenesis. Lipid uptake regulator 1 (LUR1) and N6-methyladenosine (m6A) modification play key roles in systemic lipid homeostasis. Bioinformatic anal...

Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients.

AIM: We studied the effect of O2 supplementation on physiological responses to exercise in patients with pulmonary vascular disease. METHODS: Six patients with pulmonary arterial hypertension (PAH), f...

A Comparative Analysis of Short-Term Outcomes of Off Pump Coronary Artery Bypass Grafting Alone or Simultaneous Cerebral Revascularization: A Single-Center Retrospective Study.

OBJECTIVES: The impact of simultaneous coronary artery bypass grafting (CABG) with cerebral revascularization versus CABG alone on perioperative complications and short-term outcomes remains controver...

IVUS-Guided Versus Angiography-Guided PCI for Unprotected Left Main Coronary Artery Disease: A Systematic Review, Meta-Analysis, and GRADE Assessment of Randomized Trials.

BACKGROUND: Intravascular ultrasound (IVUS) has been increasingly used as an adjunctive tool for complex percutaneous interventions (PCIs); however, comparative randomized evidence with conventional a...

Unraveling the immunotoxic link between deltamethrin and coronary heart disease through network toxicology, molecular simulations and in vitro validation.

Deltamethrin is a commonly applied pyrethroid insecticide; however, its relationship with the risk of coronary heart disease (CHD) remains unclear. Given its widespread residues in the environment and...

From Molecules to Machines: An Integrative Framework Linking Molecular Pathogenesis, Multi-Factorial Risk, Risk Stratification, Clinical Management, and Artificial Intelligence in QT Prolongation and Sudden Cardiac Death.

QT prolongation causes torsades de pointes sudden death from heritable, pharmacologic, metabolic, nutritional triggers. Its dimensions have been studied separately. This integrative review synthesizes...

Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age.

Loss of the normal heart rate variability (HRV) predicts death. This study investigated the association between carotid arterial strain (CAS) and HRV in an older age population-based cohort. We hypoth...

Left Atrial Strain in Heart Failure With Reduced Ejection Fraction (HFrEF) and Angiotensin Receptor-Neprilysin Inhibition: The CLEAR Study.

BACKGROUND: Sacubitril-valsartan (SV), an angiotensin receptor-neprilysin inhibitor, improves clinical outcomes in HFrEF patients through reverse remodeling; however, predictors of response remain unc...