Mitochondrial tRNA(Ser(AGY)) 12234A > G Mutation May Contribute to the Clinical Expression of Hypertrophic Cardiomyopathy-Associated tRNA(Ile) 4263A > G Mutation.

Mutations in mitochondrial tRNA (mt-tRNA) are found to be associated with hypertrophic cardiomyopathy (HCM), but their molecular mechanisms remain largely undetermined. In this study, we investigated ...

The effect of a family-centered empowerment model with traditional Chinese medicine health education on self-management in community-dwelling older adult hypertensive patients with a chance health locus of control.

BACKGROUND: Despite much evidence showing the effectiveness of structured self-management education for patients with hypertension (HTN), poor blood pressure control remains a challenge among chance h...

Blood pressure control after solid organ transplantation: opportunities for optimizing care.

Hypertension affects 50%-90% of solid organ transplant recipients (SOTR) and is a major driver of cardiovascular disease. Nevertheless, hypertension control has received little attention in this popul...

A rare coexistence of immunoglobulin light chain amyloidosis and POEMS syndrome manifesting as refractory heart failure: a case report and literature review.

Immunoglobulin light chain (AL) amyloidosis and POEMS syndrome are plasma cell proliferative disorders involving multiple organs and tissues, often presenting with nonspecific clinical manifestations....

Case Report: Isolated homonymous hemianopia after reversal of anticoagulation with andexanet alfa.

PURPOSE: Clinical scoring systems have been developed (e.g., CHA2DS2-VASc and HAS-BLED) to aid in the perioperative management of anticoagulation therapy. The decision to continue, modify, or stop ant...

Computational Multieffect Analysis of Blood-Based Trihybrid Nanofluid Flow With Nanoparticles Through a Stenotic Artery.

This study is aimed at examining the computational modeling of the blood flow of a trihybrid nanofluid with nanoparticles such as Ag, Au, and Cu to simulate the hemodynamics parameters and heat transf...

The role of macrophages in aortic physiology and pathophysiology.

The aorta is one of the major arterial vessels in the human body, serving as the principal conduit for the high-velocity blood ejected from the heart. For a long time, its function was largely underst...

Coil only middle meningeal artery embolization for the treatment of subdural hematoma: a single center experience.

BACKGROUND AND PURPOSE: Middle meningeal artery embolization (MMAe) has emerged as an effective adjunct or alternative to surgery for subdural hematoma (SDH). While particles and liquid embolic agents...

Association between triglyceride glucose-body mass index and clinical outcomes after septal myectomy.

AIMS: This study examined the association between triglyceride glucose-body mass index (TyG-BMI) and clinical outcomes in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing septal...

Effects of Diazepam on Oxidative Stress, Apoptosis, and Vascular Reactivity in Human Umbilical Arteries Under Experimental Hyperhomocysteinemia.

In obstetrics, diazepam is commonly used to treat anxiety, insomnia and as a second-line treatment for seizures in preeclampsia and eclampsia. However, the effects of diazepam on the oxidative balance...

Role of [123I]I-mIBG cardiac scintigraphy in the differential diagnosis of Parkinson's disease - our experience.

BACKGROUND: The clinical diagnostic accuracy of idiopathic Parkinson's disease (IPD) remains suboptimal, with the most common neuropathological findings in misdiagnosed patients being atypical neurode...

Chronic kidney disease progression rate and predictors in hypertensive patients: A 5-year retrospective follow-up study in Ethiopia.

INTRODUCTION: Chronic kidney disease is a major public health concern worldwide. Despite the well-established link between hypertension and chronic kidney disease, early detection and management of ch...

Methodological development of a pneumatic artificial muscle-driven left ventricular simulator using interpretive structural modeling.

Mock circulation systems can replicate a wide range of cardiac operating scenarios, such as cardiovascular diseases, particularly muscular dysfunctions. These systems are operated by sophisticated con...

Immune checkpoint inhibitor-related myositis, myocarditis, and myasthenia gravis overlap syndrome: a systematic review and pooled analysis of individual cases.

BACKGROUND: Immune checkpoint inhibitor (ICI)-related overlap syndrome involving myositis, myocarditis, and myasthenia gravis (3M overlap syndrome) is rare but potentially fatal. Current evidence is d...

CLEC7A as a potential biomarker of atherosclerotic response to aspirin therapy: a multi-omics analysis.

Many patients with atherosclerotic cardiovascular disease (ASCVD) do not respond well to aspirin therapy. This study employed a multi-omics approach to identify key genes associated with aspirin non-r...

Determinants of hypertension medication adherence among older adults in a resource-limited peri-urban setting, Ghana.

BACKGROUND: Hypertension is a leading cause of morbidity and mortality among older adults, with effective management heavily reliant on consistent medication adherence. AIM: This study aimed to evalua...

Anatomical assessment of the relationship between the aortic bifurcation and the vertebral body in individuals with normal vertebral column structure using computed tomography angiography.

BACKGROUND: Anterior approaches to the lumbar spine, particularly anterior lumbar interbody fusion (ALIF) at L4-L5 and L5-S1, are increasingly common. Vascular injury involving the aortic bifurcation ...

Sacubitril/Valsartan versus Enalapril or Losartan at Maximum Doses in Heart Failure with Reduced Ejection Fraction: Real-World Data.

BACKGROUND: Sacubitril/valsartan reduced mortality and hospitalizations in patients with heart failure with reduced ejection fraction (HFrEF) compared to enalapril in pivotal clinical trials. However,...

Frailty prediction in heart failure patients with acute infections: the potential role of thiazide diuretics?

BACKGROUND: Frailty remains a significant risk factor for adverse health outcomes in hospitalized patients. Few have evaluated frailty risk and its influencing factors in heart failure (HF) patients w...

Temporal Trends and In-hospital Outcomes of Transcatheter Aortic Valve Implantation in Bicuspid Aortic Valves in Brazil: A Propensity-Matched Analysis.

BACKGROUND: Bicuspid aortic valve (BAV) is a significant risk factor for aortic stenosis (AS). Yet, the outcomes of transcatheter aortic valve implantation (TAVI) remain unclear, as most randomized tr...