Impact of Higher Versus Lower Blood Pressure Targets on Pulmonary Vascular Hemodynamics During Intensive Care After Out-of-Hospital Cardiac Arrest.
BACKGROUND: Hemodynamic management after out-of-hospital cardiac arrest (OHCA) is critical, yet the impact of vasopressor-driven mean arterial pressure (MAP) targets on pulmonary circulation and right...
AI-quantified Myosteatosis at CAC CT for Prediction of Atrial Fibrillation and Heart Failure: The Multi-Ethnic Study of Atherosclerosis.
Purpose To evaluate whether the artificial intelligence (AI)-quantified mean thoracic skeletal muscle (TSM) attenuation from coronary artery calcium (CAC) scans predicts incident cardiovascular diseas...
Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.
OBJECTIVE: Obesity is a well-known heart failure (HF) risk factor, yet the biological pathways linking adiposity indices to HF remain unclear. This study aimed to identify proteomic mediators for five...
Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.
Pericytes are specialized mural cells that ensheathe microvessels and play critical roles in maintaining vascular homeostasis, regulating angiogenesis, and coordinating tissue repair. Studies in the s...
Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.
Sensory neurons innervating the heart transmit chemical and mechanical cues to the central nervous system via the dorsal root ganglion (DRG) and nodose ganglion (NG). Despite their importance in cardi...
The Immuno-Cardiovascular Storm of Pre-Eclampsia: Cytokine-Mediated Endothelial Injury, Thrombosis, and Maternal Cardiovascular Instability.
Pre-eclampsia is a complex multisystem hypertensive disorder of pregnancy and a leading cause of maternal and perinatal morbidity and mortality worldwide. Increasing evidence suggests that the conditi...
Alterations in Abdominal Blood Flows After Drinking Coffee.
Coffee exerts beneficial effects on health, such as suppressing type 2 diabetes, cardiovascular disease, and fatty liver. Coffee also relieves headaches by the caffeine component decreasing blood flow...
Radiotherapy resistance in glioblastoma: Mechanistic insights and novel therapeutic approaches (Review).
Glioblastoma (GBM) is currently the most lethal type of primary brain tumor, with a median survival time of 15‑20 months despite the use of multimodal therapy. Although radiotherapy (RT) remains a cor...
Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway.
Sepsis‑induced cardiomyopathy (SIC) is a common complication of sepsis and is associated with a high mortality rate; however, effective therapies remain lacking. Mitochondrial dysfunction is a key pat...
Quantitative Assessment of Myocardial Velocity and Dyssynchrony in Fontan Circulation Using MR Tissue Phase Mapping.
Magnetic resonance tissue phase mapping (TPM) has been used to encode voxel-wise myocardial motion velocity in various cardiac diseases. This study aimed to quantify alterations in myocardial motion v...
Atrial fibrillation in patients with alcohol-associated hepatitis leads to increased mortality.
BACKGROUND: Alcohol consumption is associated with increased risk for development of atrial fibrillation. Outcomes of patients with atrial fibrillation in the context of acute alcohol-associated hepat...
Targeted Plasma Amino Acid Metabolic Remodeling and Pharmacological Regulation in Heart Failure Rats Using PRISE-NUS-bs-HSQC 2D NMR Spectroscopy.
Nuclear magnetic resonance (NMR) metabolomics offers a robust platform for the analysis of complex biological samples, but its application is often constrained by signal overlap and limited sensitivit...
Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein.
Atherosclerosis represents a major risk factor contributing to the development and advancement of cardiovascular diseases. The present study aimed to investigate the role of impaired autophagy and mit...
Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).
Thoracic aortic aneurysm and dissection (TAAD) is a life‑threatening disease with an insidious onset and a largely elusive pathogenesis. Hereditary TAAD (HTAD) can be classified into syndromic forms, ...
Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis.
The poor prognosis of heart diseases is largely attributable to the limited proliferative capacity of cardiomyocytes. Cardiomyocyte proliferation and heart regeneration has garnered increasing attenti...
Phenotypic and transcriptional changes in human brain pericytes induced by phorbol 12-myristate 13-acetate.
Pericytes are multifunctional mural cells that contribute to vascular stability, inflammation, and fibrosis in the central nervous system. Phorbol 12-myristate 13-acetate (PMA), a potent activator of ...
Early-Onset Obesity and Heart Failure Burden Independent of Cardiometabolic Risk Factors.
The timing of obesity onset may influence long-term cardiovascular risk. Whether obesity beginning in early adulthood differs from obesity acquired later in life with respect to cardiometabolic and ca...
Comparative effects of sacubitril/valsartan versus enalapril on QRS duration and cardiac function in heart failure patients undergoing left bundle branch area pacing.
BACKGROUND: Left bundle branch area pacing (LBBaP) has emerged as a physiological pacing strategy for cardiac resynchronization therapy in patients with heart failure (HF) and left bundle branch block...
Genetic polymorphism of CYP3A4 associated with reduced response to statin therapy in Pakistani cardiac and dyslipidemic patients: A cross-sectional observational study.
BACKGROUND: Drug resistance phenomenon has become a serious problem in the lipid lowering drugs in the treatment of cardiac and dyslipidemic patients. Statins are the mainstay pharmacological treatmen...
Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review).
Cardiorenal syndrome (CRS) encompasses the bidirectional and complex interaction between cardiac and renal dysfunction. The present review focuses on CRS types 3 and 4, highlighting the negative effec...