Analysis of Matrix Metalloproteinase-8 Gene Polymorphisms and Their Association with Long-Term Survival, Clinical Phenotype, and Disease Risk in Patients with Coronary Artery Disease.
Matrix metalloproteinase-8 (MMP-8), a neutrophil-derived collagenase responsible for the degradation of type I and III collagen, is involved in extracellular matrix remodeling, which may contribute to...
[Related factors and prediction model of recurrent in-stent restenosis after DES].
Objective: To investigate the factors associated with recurrent in-stent restenosis (ISR) after drug-eluting stent (DES) implantation and to establish a screening model. Methods: This cross-sectional ...
Causal Association Between Idiopathic Pulmonary Fibrosis and Coronary Artery Disease: A Bidirectional Two-Sample Mendelian Randomization.
AIMS/BACKGROUND: Coronary artery disease (CAD) has been epidemiologically linked to idiopathic pulmonary fibrosis (IPF); however, the genetic basis of this association remains unclear. Therefore, this...
Comparison of rotational atherectomy and modified balloons for calcified lesion preparation: a single-centre experience.
AIM: To compare the efficacy and safety of rotational atherectomy (RA) and modified balloons (MB) for calcified coronary lesion preparation. METHODS: This retrospective, single-centre study included 9...
Age- and Sex-Related Patterns in Coronary CT Angiography Referrals and Coronary Atherosclerotic Burden: A Single-Center Real-World Referral-Based Analysis.
Background and Objectives: Coronary computed tomography angiography (CCTA) has become a central non-invasive imaging modality for the evaluation of suspected chronic coronary syndromes. Nevertheless, ...
Sex Differences in Long-term Outcomes Following Coronary Artery Bypass Grafting: A Nationwide Population-Based Propensity Score-Matched Cohort Study.
BACKGROUND: The relationship between sex differences and clinical outcomes following coronary artery bypass grafting (CABG) has been highlighted in several studies. However, these studies were mostly ...
Investigating the mechanisms linking vitamin D to coronary artery disease: A mediating proteomics Mendelian randomisation study.
Coronary artery disease (CAD) is a leading cause of mortality and morbidity globally, with its elevated rates of disability and death posing a significant public health concern. Vitamin D is a crucial...
Machine Learning Analysis of Sex Differences in Cardiovascular-Kidney-Metabolic Risk Factors and Prognosis Among Patients With Moderate-to-Severe Coronary Artery Calcification: Prospective Cohort Study.
BACKGROUND: Patients with coronary artery calcification exhibit notable sex differences in clinical presentation, particularly concerning the role of cardiovascular-kidney-metabolic (CKM) risk factors...
Association between Cognitive Function and Postoperative Stroke Following Off-Pump Coronary Artery Bypass Grafting.
To investigate the association between cognitive function and postoperative stroke in patients undergoing off-pump coronary artery bypass grafting (CABG). We reviewed patients who underwent cognitive ...
Clinical Significance of High-Sensitivity Cardiac Troponin I and Myoglobin in Patients with Suspected Coronary Microvascular Dysfunction.
To examine distribution of high-sensitivity cardiac troponin I (hs-cTnI) and myoglobin in patients with suspected coronary microvascular dysfunction (CMD). This study included consecutive patients wit...
Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease.
BACKGROUND: Patients with multivessel coronary artery disease often receive 12 months of dual antiplatelet therapy (DAPT) after stenting to reduce the risk of ischemic events. Whether extending DAPT b...
The Role of Long Non-Coding RNAs in the Pathogenesis of Coronary Heart Disease.
Long non-coding RNAs (lncRNAs) constitute an important group of regulatory RNA molecules involved in the control of gene expression at the epigenetic, transcriptional, and post-transcriptional levels....
Clinical factors associated with retreatment and early coronary outcomes in Kawasaki disease in children aged < 6 months: a single-center cohort study.
UNLABELLED: To evaluate whether pre-treatment coronary artery aneurysm (CAA) Z-score, inflammatory markers, and incomplete Kawasaki disease (KD) status are associated with intravenous immunoglobulin (...
BMI-Dependent Modulation of the Soluble RAGE-Sirtuin-1 Axis by Coffee Type in Coronary Artery Disease.
BACKGROUND: Coffee contains bioactive compounds associated with cardiometabolic benefits, which modulate metabolic pathways of Sirtuin-1. The AGEs-RAGE axis promotes Sirtuin-1 degradation, but soluble...
Red Cell Distribution Width-Standard Deviation and the Severity of In-Stent Restenosis: Associations with Angiographic Stenosis Burden and Mehran Classification.
Background and Objectives: Red cell distribution width-standard deviation (RDW-SD) has been associated with systemic inflammation and adverse cardiovascular outcomes, but its relationship with the ang...
Multi-Omics and Experimental Validation Reveal the Protective Effect of Paeoniflorin Against Coronary Heart Disease in Mice via Inhibiting the C3-Cfd-C3aR Pathway.
Coronary heart disease (CHD) is a global cardiovascular disease with high morbidity and mortality, and its complex pathological mechanism poses great challenges to clinical prevention and treatment. P...
Impact of Kidney Function on the Treatment Effect of Multi-Arterial Grafting in CABG Patients.
BACKGROUND: The adoption of multi-arterial grafting (MAG) remains limited in real-world coronary artery bypass grafting (CABG) practice. This study aimed to identify subsets of patients most likely to...
Abbreviated DAPT Regimens Across the Entire Spectrum of Bleeding Risk According to the PRECISE-HBR Score.
BACKGROUND: Among high-bleeding risk (HBR) patients undergoing coronary stenting, abbreviated dual antiplatelet therapy (DAPT) reduces bleeding without ischemic risk trade-off; whether these benefits ...
Causal relationship and pathogenic mechanism analysis of breast cancer and coronary heart disease based on mendelian randomization and transcriptome data analysis.
Breast cancer (BC) is closely linked to coronary heart disease (CHD), yet the genetic causal relationship and common driving mechanism between the two have not been fully elucidated. The purpose of th...
Precision Medicine for Anticoagulation Strategies in the Cath Lab: Part 1.
PURPOSE OF REVIEW: Intraprocedural anticoagulation in the cardiac catheterization laboratory is essential to prevent thrombus formation on catheters, guidewires, and stents while minimizing bleeding r...