ZHX2 Alleviates Vascular Remodeling and Smooth Muscle Cell Proliferation by Transcriptional Regulation of GADD45G.

Based on findings from human atherosclerotic arteries and mouse arterial injury models, where ZHX2 expression is significantly downregulated, this study identifies ZHX2 as a critical inhibitor of path...

Ninjurin2 Promotes Pulmonary Endothelial Barrier Dysfunction Through VEGF/VEGFR2 Signaling Pathway.

Previous studies have established an association between Ninjurin2 and diseases related to vascular endothelial dysfunction, such as ischemic stroke and coronary heart disease. Given that impaired pul...

WTAP Histone Lactylation Drives the YTHDF1/ALOX15 Axis to Regulate Ferroptosis in Myocardial Ischemia-Reperfusion Injury.

Lactate, a metabolic byproduct of glycolysis, accumulates during myocardial infarction and ischemia/reperfusion (I/R) injury, acting as both a metabolic stress marker and a signaling molecule that inf...

Nuclear m6A Methylase METTL3 Drives Production of ITGβ4E to Exacerbate Heart Failure via SRSF3-Mediated Alternative Splicing of ITGβ4.

Heart failure (HF) is an important cause of morbidity and mortality worldwide. Here, we aimed to screen potent regulators in HF progression to assist clinicians in the early diagnosis and management o...

Intracoronary imaging (ICI) is an important adjunct to invasive coronary angiography for the assessment of lesion morphology and guidance of percutaneous coronary intervention (PCI). Extensive data, i...

The Role of Endothelial Dysfunction in Fracture Healing: Mechanisms and Potential Effects on Skeletal Repair.

Fracture healing depends on coordinated osteogenesis and restoration of the vascular microenvironment. Endothelial cells support skeletal repair through angiogenesis, tissue perfusion and angiocrine s...

Putative Modulation of OATP1A2 and P-gp Expression at the Blood-Brain Barrier by Nrf2-PXR: An Associative Hypothesis for Amyloid-β Transport in Alzheimer's Disease.

Impaired amyloid-β (Aβ) clearance across the blood-brain barrier (BBB) is a major contributor to Aβ accumulation in Alzheimer's disease (AD). P-glycoprotein (P-gp) has been identified as a key BBB eff...

From Valve Disease to Valve Replacement: Lipoprotein(a) Is Associated with Aortic Stenosis Severity but Not Prognosis After TAVI.

Background: Lipoprotein(a) [Lp(a)] has emerged as a key mediator of calcific aortic valve disease and is strongly linked to the development and progression of aortic stenosis (AS). Whether elevated Lp...

Mitral valve vegetations in an elderly patient with acute myeloid leukemia: navigating the overlap between infection and malignancy: a case report.

BACKGROUND: Acute myeloid leukemia (AML) is a hematologic malignancy that can rarely manifest with clinical features resembling infective endocarditis (IE), particularly in elderly individuals. Non-ba...

Optical System for Assessment of Atrial and Ventricular Mechanics in Langendorff-perfused Mouse Hearts.

The mouse heart serves as a widely used model in cardiovascular research, facilitated by advances in engineering technologies. However, assessment of atrial and ventricular contractility remains chall...

Tail Artery Blood Sampling in Isoflurane Anesthetized Rats Reduces Stress and Improves Reliability.

This method describes blood sampling via the tail artery in isoflurane-anesthetized rats. The use of isoflurane minimizes defensive movements, thereby enabling a controlled, low-stress procedure for b...

TLR2 mediates cell cycle re-entry and survival of neonatal cardiomyocytes in response to injury.

Unlike adult hearts, neonatal hearts can regenerate and adapt to stress. To identify both cardioprotective and regenerative mechanisms, we compared activated genes and related signaling pathways in th...

Modified pulmonary artery obstruction index for thrombolysis assessment in intermediate-risk pulmonary thromboembolism: A retrospective cohort study.

Acute non-high-risk pulmonary thromboembolism (PTE) is generally relieved within months of anticoagulation treatment initiation. However, some patients experience complications. This study aimed to as...

Predictors of 1-year fibrosis in treatment-naïve neovascular age-related macular degeneration: the role of baseline OCTA-derived MNV vessel density.

BACKGROUND: To investigate baseline and post-loading optical coherence tomography angiography (OCTA) characteristics associated with 1-year fibrosis in treatment-naïve neovascular age-related macular ...

LncRNA DLX6-AS1 promotes necroptosis through PI3K/AKT/mTOR signaling pathway in myocardial ischemia/reperfusion injury mice.

Myocardial ischemia/reperfusion injury (MIRI) leads to life-threatening myocardial infarction. Necroptosis is involved in MIRI. The lncRNA DLX6-AS1 was found to participate in the context of MIRI. In ...

Interplay of patent foramen ovale and atrial septum aneurysm in a nonagenarian patient presenting with platypnoea-orthodeoxia syndrome.

Patent foramen ovale (PFO) is a common congenital cardiac anomaly, generally responsible for cryptogenic stroke. Still, it can cause severe positional hypoxia via a right-to-left shunt if associated w...

Endomyocardial Biopsies in the Diagnostic Workup of Immune Checkpoint Inhibitor Associated Myocarditis.

PURPOSE OF REVIEW: To identify the role of endomyocardial biopsy in the diagnosis, prognostication, and future understanding of mechanisms for immune checkpoint inhibitor myocarditis. RECENT FINDINGS:...

Object size-dependent bias in aortic valve calcium quantification: polychromatic images vs virtual monochromatic images.

OBJECTIVES: To compare aortic valve calcification (AVC) quantifications between polychromatic images (PI) and 70-keV virtual monochromatic images (VMI) obtained from photon-counting detector CT (PCD-C...

MicroRNAs in dilated cardiomyopathy: from biomarkers to therapeutic targets.

Dilated cardiomyopathy (DCM) remains a leading cause of non-ischemic heart failure and sudden cardiac death, with substantial heterogeneity in clinical presentation and outcomes. Conventional diagnost...

The regulatory network of Mfsd2a in cerebral ischemia: a novel time-targeted intervention framework.

Cerebral ischemia‒reperfusion injury disrupts blood-brain barrier (BBB) integrity, a process strongly linked to the downregulation of the lipid transporter Mfsd2a. Prior research has focused on the co...