Rethinking atrial pacing support in cardiac resynchronization therapy: insights from the CRT-NEXT trial.
Cardiac resynchronization therapy defibrillators traditionally require a dedicated right atrial lead to provide atrial sensing and pacing in addition to biventricular pacing. However, the clinical val...
Native myocardial T1 reference values in a tunisian cohort using MOLLI and SMART1Map : List of Authors.
Native T1 values in cardiac magnetic resonance (CMR) are influenced by acquisition sequence, physiological factors, and site-specific variability, complicating clinical interpretation. The absence of ...
Shifting the Balance: Mitochondrial Heteroplasmy as a Driver of Cardiac Disease.
Mitochondrial heteroplasmy represents a fundamental determinant of mitochondrial function and disease, yet its consequences vary across different tissues. Although mitotic tissues possess mechanisms, ...
Surgical myectomy (SM), performed to relieve dynamic left ventricular outflow tract obstruction (LVOTO) in symptomatic obstructive hypertrophic cardiomyopathy (oHCM) patients provides improved quality...
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder that affects cardiovascular, musculoskeletal, and ocular tissues, with premature death often resulting from dissection of the ...
A myocardial bridge (MB) can cause angina in patients with non-obstructive coronary arteries. For patients with a functionally significant MB and severe angina despite maximal medical therapy, surgica...
Although prompt primary percutaneous coronary intervention (PCI) reduces mortality in patients with ST-elevation myocardial infarction (STEMI), the burden of post-infarction heart failure remains cons...
The prevalence of mechanical complications following acute myocardial infarction has steadily declined in recent years owing to advances in prompt coronary revascularization, and they now occur in <1%...
Corosolic Acid Induces Endothelium-Dependent Vasorelaxation in Isolated Rat Aortic Rings.
The effect of Corosolic acid (CA) on vascular tone and the possible mecha-nisms involved remain unclear. The SPF-grade male Sprague-Dawley rats (Animal Ethics Approval ID: USM/IACUC/2025/(155)(1406)) ...
Restoring autophagy-apoptosis balance in diabetic cardiomyopathy via a biomimetic, ROS-responsive nanocarrier associated with Mst1 pathway modulation.
Diabetic cardiomyopathy (DCM) is driven by oxidative stress and an imbalance between autophagy and apoptosis. To improve myocardial delivery of dimethyl fumarate (DMF), a known NRF2-activating redox m...
Coarctation-like features from skeletal anomalies: recognising extrinsic compression in fetal echocardiography.
Prenatal diagnosis of coarctation of the aorta (CoA) remains a challenging diagnosis in fetal cardiology. In rare situations, extrinsic compression of the aorta can produce a pseudocoarctation-like ap...
A cross-organ single-cell analysis of hypertension.
Hypertension is a leading cause of disease burden and mortality. Here, we present a single-cell analysis of hypertension and end-organ damage across six organs and tissues in angiotensin II-treated mi...
Design and Preclinical Evaluation of 18F-Labeled Phenoxyalkylguanidines as Novel Norepinephrine Transporter Radiotracers for Myocardial and Tumor Imaging.
The norepinephrine transporter (NET) is a key target for PET imaging of sympathetic nerves and neuroendocrine tumors. Herein, we developed a series of novel aryl 18F-labeled phenoxyalkylguanidine PET ...
Dynamic Evaluation of Vascular Remodeling and Aneurysm Progression Using Blood-Pool Contrast-Enhanced In Vivo Micro-CT in a Rodent Model.
Vascular graft remodeling and aneurysm progression are commonly studied in small animal models, but non-terminal methods for their assessment remain limited. This study evaluated contrast-enhanced mic...
A high-sensitivity TIE2-GRB2 BRET platform for functional and pharmacologic profiling of pathogenic variants associated with venous malformations.
TIE2 is an endothelial receptor tyrosine kinase (RTK) essential for vascular integrity, and constitutively active TIE2 mutants are involved in venous malformations (VMs). VMs are currently treated by ...
Exercise and Cardiovascular Risk Modulation in Post-COVID Syndrome.
PURPOSE OF REVIEW: Post-COVID syndrome (PASC) has emerged as a multisystem condition associated with persistent cardiovascular abnormalities, including endothelial dysfunction, arterial stiffness, chr...
Shock Induced Endotheliopathy and High Trauma Mortality-Fight-or-Flight Response Revisited.
Trauma with hemorrhagic shock causes about 2.3 million deaths yearly worldwide. Improved hemostatic management has shifted the relative distribution of mortality, leaving multiorgan failure (MOF) as a...
Cardiomyocyte-Specific bcl11b Knockout Causes Left Ventricular Noncompaction by Dysregulating pou3f2 and Titin.
Left ventricular noncompaction (LVNC) is a cardiomyopathy characterized by excessive trabeculation and deep intertrabecular recesses, yet its molecular mechanisms remain poorly understood. Here, we id...
Endovascular thrombectomy alone versus intravenous thrombolysis plus endovascular thrombectomy on acute basilar artery occlusion (ATTENTION IV): study protocol for a multicentre randomised controlled trial.
INTRODUCTION: The DEVT and DIRECT-MT trials showed that endovascular thrombectomy (EVT) alone is non-inferior to intravenous thrombolysis (IVT) followed by EVT in achieving 90-day functional independe...
Rare culprit and clinical dilemma: thrombolysis in a spontaneous anterior cerebral artery dissection.
Intracranial arterial dissection (IAD) is a rare cause of ischaemic stroke, with involvement of the anterior cerebral artery (ACA) being uncommon. We present the case of a woman in her mid-40s who dev...