Sigma 1 Receptor Activation Coordinates Metabolic Stress Responses to Protect Retinal Vasculature in Ischemic Retinopathy.

PURPOSE: Retinopathy of prematurity (ROP)-associated vision loss is driven by pathological retinal angiogenesis. Current therapies suppress neovascularization but do not fully restore vascular integri...

Upper gastrointestinal hemorrhage due to splenic artery pseudoaneurysm combined with pancreatic pseudocyst recurrence: A case report.

Intracapsular hemorrhage occurs occasionally in acute pancreatitis complicated with pseudocyst that can be managed using laparoscopic gastric cyst anastomosis and drainage. However, cyst recurrence ma...

The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes.

PURPOSE: The purpose of this study was to investigate the effect of myopia on the optic disc morphology and retinal vascular geometry in anisometropic eyes. METHODS: This self-controlled study include...

Ellagic Acid Attenuates Oxidative Stress and Improves Cardiovascular Function Following Myocardial Infarction in Ovariectomized Rats.

Oestrogen deficiency increases oxidative stress and reduces nitric oxide (NO) bioavailability, contributing to cardiac fibrosis following myocardial infarction (MI). This study investigated whether el...

Yiqi Huoxue formula relieves heart failure with reduced ejection fraction in calcium/calmodulin-dependent protein kinase Ⅱ delta B isoform and calcium/calmodulin-dependent protein kinase Ⅱ delta C isoform transgenic mice by inhibiting myocardial remodeling and enhancing calcium homeostasis.

OBJECTIVE: To confirm the efficacy of Yiqi Huoxue formula (, YQHX) on heart failure with reduced ejection fraction (HFrEF), and elucidate its potential effect on calcium homeostasis. METHODS: Cardiac ...

Hepatic portal venous gas in severe neurocritical illness after intracranial surgery: Two case reports and literature review.

Hepatic portal venous gas is an uncommon radiologic finding that has been rarely reported in neurocritical care settings. This article presents two clinically instructive case reports of severe neurol...

Shape and size of foveal avascular zone in normal subjects using optical coherence tomography angiography (OCTA) : A retrospective analysis.

OBJECTIVE: To determine the shape and size of foveal avascular zone in terms of perimeter, circularity, roundness and axial ratio using optical coherence tomography angiography. METHODS: The retrospec...

Management of Meningioma invading Superior Sagittal Sinus: Surgery and Radiosurgery.

Parasagittal meningiomas that invade the superior sagittal sinus (SSS) pose a dual hazard: recurrence if tumour is left behind, and venous infarction if a functional sinus or bridging vein is compromi...

The Right Ventricle in Cardiac Critical Care: Pathophysiology, Evaluation and Management.

The right ventricle (RV) is a primary determinant of outcomes in cardiac critical care. RV dysfunction independently predicts morbidity and mortality in conditions such as acute coronary syndromes, pu...

The "Brain's Traffic Map" Reveals Neural Pathways Linked to Coronary Microvascular Dysfunction in Women.

BACKGROUND: The brain-heart axis is central to vascular health, yet no imaging biomarkers capture integrated dysfunction across neural and coronary microvascular networks. Although coronary microvascu...

Analysis of Myocardial Textures in Relation to Nicotine Abuse Using Radiomics in Cardiac PCCT.

Background/Objectives: Photon-counting computed tomography (PCCT) combined with radiomics enables advanced myocardial tissue characterization beyond conventional imaging. This study investigated wheth...

Transient outward K+ current inhibition suppresses early afterdepolarizations and ventricular arrhythmias via trajectory displacement away from an oscillatory regime.

Excitable biological systems can undergo abrupt transitions from stable rhythmic activity to pathological oscillations through subtle changes in slow-fast dynamical structure. In cardiac ventricular m...

Retinal Ischemic Perivascular Lesions in Pulmonary Hypertension: Retinal Biomarkers Informing Systemic Microvascular Dysfunction.

PURPOSE: Retinal ischemic perivascular lesions (RIPLs), seen on optical coherence tomography (OCT) as localized retinal changes, are markers of subclinical retinal infarcts. RIPLs are linked to system...

Left Atrial Volume and Strain by Two-Dimensional Versus Three-Dimensional Echocardiography in Healthy Subjects: Reference Values are Not Interchangeable.

BACKGROUND: Little is known about the differences in left atrial (LA) volume and strain assessed with two-dimensional (2DE) and three-dimensional echocardiography(3DE). Therefore, this study aimed to ...

Insights on Endothelial Injury.

Endothelial barrier dysfunction is the hallmark of severe disease, including sepsis and lung injury. The present study summarizes recent advances in the development of pharmacotherapies to counteract ...

Alveolar Capillary Dysplasia With Misaligned Pulmonary Veins (ACDMPV): Description of Two Cases and Literature Review.

INTRODUCTION: Alveolar capillary dysplasia with misaligned pulmonary veins (ACDMPV) is one of the major causes of neonatal interstitial lung disease, causing persistent pulmonary hypertension (PH) of ...

Dynamic needle tip positioning may improve first-attempt success rate in short-axis radial artery cannulation: A systematic review and meta-analysis of randomized trials.

BackgroundUltrasound-guided radial artery cannulation is routinely performed; however, the optimal imaging approach remains debated. The short-axis out-of-plane approach facilitates vessel centering; ...

Inflammatory Neovascularization and Vascular Remodeling Associated With Carotid Plaque Destabilization.

AIMS: Inflammatory responses promote pathological neovascularization and vascular remodeling in carotid plaques, contributing to plaque destabilization. This study aims to clarify specific cellular su...

Learning from a pitfall: Atrial septostomy in LV failure under VA-ECMO for pulmonary hypertension.

BACKGROUND: Atrial septostomy has been successfully used in patients with pulmonary hypertension and in those supported with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) complicated by ...

Network Pharmacology Reveals the Mechanism of Sini Decoction Against Aconitum carmichaelii Debeaux-Induced Cardiotoxicity.

Sini Decoction (SND), particularly its components Zingiber officinale Roscoe and Glycyrrhiza uralensis Fisch, is traditionally used to mitigate the cardiotoxicity induced by Aconitum carmichaelii Debe...